Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of andrographolide and glycyrrhizin double drug nanocomposite particle and its preparation method and application

A nano-composite particle and andrographolide technology, which is applied in the directions of drug combinations, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve problems such as no research reports on andrographolide and glycyrrhizin dual-drug synergistic drug-carrying preparations. , to achieve the effect of improving dissolution rate and bioavailability, good application prospect and easy industrialization

Active Publication Date: 2019-04-30
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is currently no research report on the realization of andrographolide and glycyrrhizin double-drug synergistic drug-loading preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of andrographolide and glycyrrhizin double drug nanocomposite particle and its preparation method and application
  • A kind of andrographolide and glycyrrhizin double drug nanocomposite particle and its preparation method and application
  • A kind of andrographolide and glycyrrhizin double drug nanocomposite particle and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The embodiments of the present invention will be described in detail below in conjunction with specific examples, which are only used to illustrate the present invention, and should not be regarded as limiting the scope of rights of the present invention. For those not marked with specific conditions in the implementation plan, follow the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not marked with manufacturers, and they were all conventional products that could be purchased from the market. Embodiment 1: Preparation of andrographolide nanocrystal suspension

[0039] Take by weighing the Glycyrrhizin of 0.05g, obtain Glycyrrhizin solution; Then, the Andrographolide of 0.5g is dispersed in Glycyrrhizin solution, shear through high-speed shear emulsification method, rotating speed is: 13000rpm, shearing time is 5min; The primary suspension with an average particle size of 40 μm is obtained; then the above...

Embodiment 2

[0042] Embodiment 2: Determination of the dissolution rate of andrographolide nanocrystal suspension

[0043] Dissolution was determined by the paddle method, using 900 mL of pH 7.4 phosphate buffer solution as the dissolution medium, and the speed was 100 r min -1 , the temperature of the water bath is 37°C. Precisely pipette the same amount of andrographolide bulk drug and the nanocrystal suspension prepared by the above example 1, place in the dissolution cup for 0.5min, 1min, 1.5min, 4min, 6min, 10min, 20min, and take a sample after 30min 1 mL, filtered through a 0.22 μm microporous membrane, determined by HPLC, according to the standard curve of andrographolide, A=29593C (R 2 =0.9994), linear range 0.0456~0.0912mg / ml, calculate its dissolution rate, and the dissolution rate of andrographolide nanocrystal suspension liquid is shown in Table 2.

[0044] Table 2 andrographolide nanocrystal suspension external dissolution evaluation

[0045]

[0046] As shown in Table 2...

Embodiment 3

[0047] Example 3: Preparation of spray-dried andrographolide-glycyrrhizin nanocomposite particle powder

[0048] Experimental method: Take the nanocrystal suspension sample prepared according to the experimental method of Example 1, add 1.0g of lactose to disperse and dissolve, and then use spray drying technology. The speed is 5ml / min, drying and solidifying to obtain spray-dried andrographolide-glycyrrhizin nanocomposite particle powder.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses andrographolide and glycyrrhizin dual-drug nano-composite particles and a preparation method and application thereof, and belongs to the field of drug preparation. The nano-composite particles adopt andrographolide nanocrystals as cores, and are of a nano-particle structure by adopting glycyrrhizin with the pharmacologic action and the natural surface activity attributes as shells. The andrographolide and glycyrrhizin dual-drug nano-composite particles have the advantages that the nano-composite particles can remarkably improve the dissolving speed and bioavailability of andrographolide, meanwhile, cooperative drug administration of andrographolide and glycyrrhizin is achieved, and the drug compatibility curative effect can be brought into play, the preparation dosage containing the composite particles is further processed conveniently, and clinic application is convenient. The preparation technology is simple, no toxic solvent is adopted or no surface active agent or high polymer materials are synthesized, the safety is high, the cost is low, industrialization is easy, and the good application prospect is achieved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an andrographolide-glycyrrhizin double-drug nanocomposite particle, a preparation method and application thereof. Background technique [0002] Andrographolide is a diterpene lactone compound extracted from Andrographis paniculata. Modern studies have shown that andrographolide has functions such as anti-inflammatory, anti-tumor, immune stimulation, liver protection and gallbladder, and CCl 4 , D-galactosamine, and acetaminophen have a significant protective effect on liver damage, can significantly reduce the levels of SGPT, SGOT, SALP, and HTG, and inhibit the apoptosis of liver cells and the inflammatory response of the liver. It has important application value in the fields of infection, liver injury and other diseases. However, andrographolide has poor water solubility (69 μg / ml at 22°C) and poor stability (easy to ring-open, dehydrate, isomerize, etc. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K9/16A61K47/28A61P31/12A61P1/16A61P11/00A61K31/365
CPCA61K9/1623A61K31/365A61K31/704A61K2300/00
Inventor 岳鹏飞杨明谢元彪郑琴伍振峰胡鹏翼王雅琪
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com