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Antibacterial gel containing nano gold

A kind of nano-gold and gel technology, which is applied in the directions of antibacterial drugs, heavy metal active ingredients, medical preparations with non-active ingredients, etc. problems, to achieve the effect of simple process, excellent broad-spectrum antibacterial properties, and strong patient adaptability

Inactive Publication Date: 2016-11-09
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The gold nanoparticles synthesized in the above report need dialysis treatment, the process is more complicated, and the process needs to be further simplified; the simple gold nanometer solution is not easy to be used in clinical wound treatment and repair, and the antibacterial performance needs to be further improved
[0006] At present, there is no public literature at home and abroad to report antibacterial gels made of gold nanoparticles.

Method used

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  • Antibacterial gel containing nano gold
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  • Antibacterial gel containing nano gold

Examples

Experimental program
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Effect test

Embodiment 1

[0058] This example is used to illustrate the antibacterial gel containing nano gold of the present invention and its preparation method.

[0059] Formula of antibacterial gel (by weight): 4,6-2 amino-2-mercaptopyrimidine / metformin as two-component modified gold nanoparticles: 0.01%; carbomer: 1%; triethanolamine: 1% ; Glycerin: 5%; Ethanol: 5%; the balance of purified water.

[0060] Preparation steps:

[0061] (1) 4,6-2 amino-2-mercaptopyrimidine / metformin as a two-component modified gold nanoparticle (can be a nanogold solution containing the nanogold particle) is added to dilute and dissolve in purified water, and then add carbomer , disperse, stir and swell to obtain a swelling solution;

[0062] (2) Glycerin, triethanolamine and ethanol are mixed until uniform, and the oil phase mixed liquid is obtained;

[0063] (3) Add the oil phase mixed solution into the swelling solution under stirring, and stir evenly to prepare the antibacterial gel containing nano-gold.

[00...

Embodiment 2

[0080] This example is used to illustrate the antibacterial gel containing nano gold of the present invention and its preparation method.

[0081] Antibacterial gel formula (by weight): 4,6-2 amino-2-mercaptopyrimidine modified gold nanoparticles as a single component: 0.02%; sodium hyaluronate: 1%; glycerin: 5%; ethanol : 5%; Nepal gold ethyl ester: 0.005%; the balance is purified water.

[0082] Preparation steps:

[0083] (1) adding 4,6-2amino-2-mercaptopyrimidine as a single-component modified gold nanoparticle into purified water to dilute and dissolve, then adding sodium hyaluronate, dispersing, stirring and swelling, and preparing a swelling solution;

[0084] (2) dissolving ethyl Nepalgold in ethanol, adding glycerin and mixing until uniform, to obtain an oil phase mixture;

[0085] (3) Add the oil phase mixed solution into the swelling solution under stirring, and stir evenly to prepare the antibacterial gel containing nano-gold.

[0086] The preparation method of ...

Embodiment 3

[0094] This example is used to illustrate the antibacterial gel containing nano gold of the present invention and its preparation method.

[0095] The prescription of antibacterial gel (by weight percentage): nano gold-platinum (gold content 80% atomic percentage, platinum content 20% atomic percentage) bimetallic nanoparticle: 0.04%; Carbomer: 1%; Triethanolamine: 1% %; glycerol: 3%; the balance is purified water.

[0096] Preparation steps:

[0097] (1) Dilute and dissolve the nano-gold-platinum bimetallic nanoparticles with purified water, then add carbomer, disperse, stir and swell to obtain a swelling solution;

[0098] (2) Glycerin and triethanolamine are mixed until uniform, and the oil phase mixed liquid is obtained;

[0099] (3) Add the oil phase mixed solution into the swelling solution under stirring, and stir evenly to prepare the antibacterial gel containing nano-gold.

[0100] The preparation method of above-mentioned nano-gold-platinum bimetallic nanoparticle...

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Abstract

The invention provides antibacterial gel containing nano gold. The antibacterial gel is prepared from the following components in percentage by weight: 0.5%-2% of a gel matrix, 0-2% of an alkaline substance, 0-20% of a humectant, 0-20% of ethanol, no more than 0.5% of nano-particles having an antibacterial function and containing the nano gold, 0-0.2% of a preservative and water. The antibacterial gel containing the nano gold, provided by the invention, has an excellent broad-spectrum antibacterial property and the toxicity to human body cells is much lower than that of antibacterial gel which is sold in the market and contains nano silver or other silver ions; the gel does not cause pain feeling on patients and has relatively strong patient adaptability; and the antibacterial gel can be used for various types of wounds, gynecological diseases and anorectal diseases and can also be matched with traditional wound dressing.

Description

technical field [0001] The invention relates to an antibacterial gel, in particular to an antibacterial gel containing nano gold, and a preparation method and application of the antibacterial gel. Background technique [0002] When treating a patient's wound, it is necessary to cover the wound with a dressing to prevent bacterial ingress and moisture loss. Although traditional dressings such as gauze and cotton pads have a protective effect on the wound surface, they are not satisfied with the hemostatic effect and have no moisturizing effect. It is generally believed that they have no promoting effect on wound healing. Gel dressings added with antibacterial agents can overcome some deficiencies of traditional dressings, and are widely used in the medical field. Gel is widely used in the treatment of surgical trauma, skin inflammation, gynecological inflammation, and rectal inflammation. [0003] Many gel dressings or medicines contain antibacterial ingredients that have s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/32A61K47/38A61K33/24A61P31/04A61P17/02A61P17/00A61P15/00A61P1/00
CPCA61K9/06A61K33/24A61K47/32A61K47/36A61K47/38
Inventor 蒋兴宇孟宏宇张伟
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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