A method for degrading large molecular weight polysaccharides containing β-1,3-glucosidic bonds

Abstract

The invention relates to a method for degrading large-molecular weight polysaccharide containing beta-1,3-glucosidic bonds. The method comprises the specific steps that a large-molecular weight polysaccharide solution containing beta-1,3-glucosidic bonds with the concentration being 60-200 mg / mL is introduced into an electrolytic cell provided with cathodes and anodes, the solution is adjusted to be acid, oxygen is introduced into the cathode on the basis of the amount of the 4.0-8.0 L oxygen / L polysaccharide solution, direct current is introduced and controls the current density of the cathode to be 9-14 mA / cm<2>, on the condition, degradation is performed, and an electrolyte is collected. The method is simple technology and easy to implement, time is saved, the method is efficient, and large-scale production is promoted; reaction conditions are mild, and environment pollution is small; importantly, compared with acid process degradation and hydrogen peroxide degradation method, the polysaccharide degradation rate is high through the electric Fenton method, and the range of the obtained low-molecular-weight polysaccharide molecular weight is narrower on the condition that the polysaccharide of equivalent molecular weight is degraded.

Description

technical field [0001] The invention relates to the field of production of pharmaceutical raw materials, in particular to a method for degrading large-molecular-weight polysaccharides containing β-1,3-glucosidic bonds. Background technique [0002] Polysaccharide is formed by the condensation and dehydration of multiple monosaccharide molecules. It is a kind of carbohydrate with complex molecular structure and huge size. Active polysaccharide refers to a polysaccharide compound with special physiological activity, which has the function of regulating the circadian rhythm of the human body. Monosaccharides in polysaccharides are connected by glycosidic bonds, and glycosidic bonds include β-1,4-glycosidic bonds, α-1,3-glycosidic bonds, β-1,3-glycosidic bonds, etc. [0003] Studies have shown that the biological activity of polysaccharides is closely related to its molecular weight. The larger the molecular weight, the larger the molecular volume, and the poor solubility. lear...

AI Technical Summary

Problems solved by technology

However, the cleavage of glycosidic bonds in the acid degradation method is random, and the molecular weight distribution of the product is wide, which is destructive to the structure and activity of the product.

The hydrogen peroxide degradation method requires the use of hydrogen peroxide, which is potentially dangerous during storage and transportation, and has a low degradation rate, so it is not suitable for industrialized expansion of production

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