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Oral composition for inhibiting halitosis

An oral composition and bad breath technology, which is applied in oral care, cosmetic preparations, dressing preparations, etc., can solve the problems of food chewing function decline and impact, and achieve the effect of inhibiting bad breath and dental caries

Inactive Publication Date: 2016-11-23
株式会社 花伊美制药
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although tooth decay is not directly related to human life, it leads to a decline in the chewing function of food, so it has a direct or indirect impact on digestive system diseases

Method used

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  • Oral composition for inhibiting halitosis
  • Oral composition for inhibiting halitosis
  • Oral composition for inhibiting halitosis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0049] the antibacterial force test of mutans streptococcus (Streptococcus mutans)

[0050] The oral composition of above-mentioned comparative example 1, embodiment 1 and 2 is formulated into toothpaste, and the oral composition of 2 g of the oral composition formulated into toothpaste is diluted and suspended in the phosphate buffer solution of sterilized 9 g, through the following method was experimented.

[0051] Table 1

[0052] [Table 1]

[0053] Raw material name

Comparative example 1

Example 1

Example 2

Amorphous Sorbitol

30

30

30

polyethylene glycol 300

2

2

2

carboxymethyl cellulose

1

1

1

tocopheryl acetate

-

0.1

0.1

sodium saccharin

0.22

0.22

0.22

malic acid

-

0.1

0.1

calcium phosphate dichloride

0.1

0.1

0.1

Precipitated silica (for abrasives)

30

30

30

Precipitated silica (for thickening)

3

3

3

s...

experiment example 2

[0059] Antibacterial power test in anaerobic microorganisms

[0060] As in Experimental Example 1, 2 g of oral compositions of Comparative Examples and Examples were diluted and suspended in 9 g of phosphate buffer solution sterilized, and experiments were performed by the following method. The MIC method was performed in the same manner as in Experimental Example 1. However, anaerobic microorganisms do not grow in the presence of oxygen, so when supplied with 5% hydrogen (H 2 ) and 95% nitrogen (N 2 ) in an anaerobic medium (Sheldon Manufacturing Bac 2-2E) and experimented with it, the results are shown in Table 3 below.

[0061] table 3

[0062] [table 3]

[0063]

[0064] As a result, the oral composition (Examples 1 and 2) comprising the Chinese medicine prescription of the present invention is similar to Comparative Example 1 in antibacterial activity, but also shows antibacterial activity to Porphyromonas gingivalis as periodontitis-causing bacteria, From this, ...

experiment example 3

[0065] Evaluation of activity inhibition performance of MMP-3

[0066] As shown in the following Table 4, formulations except sodium fluoride, sodium lauryl sulfate, spices (flavor), pigments, etc. were used from the oral compositions of Comparative Example 1 and Examples 1 and 2 (Comparative Example 2 , Examples 3 and 4), the activity inhibition performance of MMP-3 was evaluated.

[0067] Table 4

[0068] [Table 4]

[0069] Raw material name

Comparative example 2

Example 3

Example 4

Amorphous Sorbitol

30

30

30

polyethylene glycol 300

2

2

2

carboxymethyl cellulose

1

1

1

tocopheryl acetate

-

0.1

0.1

sodium saccharin

0.22

0.22

0.22

malic acid

-

0.1

0.1

calcium phosphate dichloride

0.1

0.1

0.1

Scutellaria baicalensis extract

0.5

0.5

Nepeta Extract

0.5

0.5

Forsythia Extract

-

0.5

Honeysuckl...

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Abstract

The present invention relates to an oral composition which has excellent effects in halitosis inhibition, dental caries inhibition and peridontal disease inhibition, the oral composition comprising natural medicinal ingredient extracts essentially comprising Scutellariae Radix extract and Nepetae Spica extract, and additionally comprising forsythia fruit extract, lonicer aflower extract and platycodi radix extract, etc., and the oral composition further comprising tocopheryl acetate and malic acid. The oral composition comprises 0.1 to 5.0 % by weight of a mixture of the natural medicinal ingredient extracts including Scutellariae Radix extract and Nepetae Spica extract, 0.01 to 1.0 % by weight of tocopheryl acetate, and 0.01 to 1.0 % by weight of malic acid.

Description

technical field [0001] The present invention relates to an oral composition for halitosis suppression. In particular, it relates to an oral composition comprising a Scutellaria baicalensis extract and a Schizonepeta extract as essential components, and in addition, an extract of forsythia, honeysuckle, and bellflower. Extracts of natural medicinal materials such as extracts, and on this basis, also contain acetic acid tocopherol (Acetic acid Tocopherol) and malic acid, thereby having excellent effects on inhibiting bad breath, inhibiting dental caries, and inhibiting periodontal disease. Background technique [0002] Tooth decay is a disease in which carbohydrates in food are metabolized by microorganisms present in the bacterial film on the tooth surface above and below the gums, and the hard tissue of the tooth is destroyed by the action of locally produced organic acids. The prevention of tooth decay is not only In our country, but also worldwide attention. Although toot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/67A61Q11/00
CPCA61K8/365A61K8/678A61K8/9789A61K2800/5922A61Q11/00A61K8/36A61K8/67A61K8/922A61K8/965A61K2800/59A61K2800/80
Inventor 张善五
Owner 株式会社 花伊美制药