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Method for preparing composite bone cement bracket

A technology of bone cement and ink, applied in the field of materials science, can solve the problems of poor mechanical support performance, degradability and biological activity, and the inability to precisely control the connectivity of scaffold holes, so as to achieve high mechanical strength and promote proliferation. Effect

Inactive Publication Date: 2016-12-07
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a method for preparing a composite bone cement scaffold. The method for preparing the composite bone cement scaffold should solve the problem that the bone tissue engineering scaffold prepared in the prior art cannot be accurately Regulating the internal structure of the scaffold and the connectivity of the pores, mechanical support performance, degradability and biological activity are not ideal technical issues

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  • Method for preparing composite bone cement bracket
  • Method for preparing composite bone cement bracket
  • Method for preparing composite bone cement bracket

Examples

Experimental program
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Effect test

Embodiment 1

[0021] A preparation method of a composite bone cement support, comprising the following steps:

[0022] Step 1, preparing CSH / MBG composite printing ink. Mix CSH and MBG powder evenly at a mass ratio of 80:20, pass through a 400-mesh sieve, and then take 1.8 grams of mixed vermicelli and add it to 2 ml of polycaprolactone (PCL) / dichloromethane solution (0.1g / ml) In the middle, stir quickly evenly, and then seal and store.

[0023] Step 2, designing the appearance and internal structure of the CSH / MBG composite bone cement scaffold. Use CAD / CAM and other computer-aided software to design the appearance and internal structure of the bracket. The bracket model is a cylinder (φ=8mm, h=2mm), the inner diameter is 400μm, and the angle between two adjacent layers of ink is 60°.

[0024] Step 3, low temperature 3D printing technology to prepare CSH / MBG composite bone cement scaffold. Put the prepared printing ink into the barrel of the 3D printer, then install a needle with a diam...

Embodiment 2

[0027] A preparation method of a composite bone cement support, comprising the following steps:

[0028] Step 1, preparing CSH / MBG composite printing ink. Mix CSH and MBG powder evenly at a mass ratio of 70:30, pass through a 600-mesh sieve, and then take 1.8 grams and add it to 2.5 ml of polycaprolactone (PCL) / chloroform solution (0.1g / ml) , Stir quickly and evenly, then seal and store.

[0029] Step 2, designing the appearance and internal structure of the CSH / MBG composite bone cement scaffold. Use CAD / CAM and other computer-aided software to design the appearance and internal structure of the bracket. The bracket model is a cylinder (φ=8mm, h=8mm), the inner diameter is 200μm, and the angle between two adjacent layers of ink is 60°.

[0030] Step 3, low temperature 3D printing technology to prepare CSH / MBG composite bone cement scaffold. Put the prepared printing ink into the barrel of the 3D printer, then install a needle with a diameter of 200 microns, and pre-cool at...

Embodiment 3

[0033] A preparation method of a composite bone cement support, comprising the following steps:

[0034] Step 1, preparing CSH / MBG composite printing ink. Mix CSH and MBG powder evenly at a mass ratio of 60:40, pass through a 300-mesh sieve, and then take 1.8 grams and add it to 2 ml of polycaprolactone (PCL) / dichloromethane solution (0.1g / ml) , Stir quickly and evenly, then seal and store.

[0035] Step 2, designing the appearance and internal structure of the CSH / MBG composite bone cement scaffold. Use CAD / CAM and other computer-aided software to design the appearance and internal structure of the bracket. The bracket model is a cylinder (φ=8mm, h=2mm), the inner diameter is 600μm, and the angle between two adjacent layers of ink is 90°.

[0036] Step 3, low temperature 3D printing technology to prepare CSH / MBG composite bone cement scaffold. Put the prepared printing ink into the barrel of the 3D printer, then install a needle with a diameter of 600 microns, pre-cool at ...

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Abstract

The invention relates to a method for preparing a composite bone cement bracket. The method comprises the steps: preparing calcium sulfate / mesoporous bioactive glass composite ink; designing the appearance and an internal structure of the composite bone cement bracket: designing the appearance and the internal structure of the bracket by using CAD / CAM computer aided software; preparing a calcium sulfate / mesoporous bioactive glass composite bone cement bracket by using a low-temperature 3D print technique: printing ink lines to a glass culture dish of an objective table, and carrying out accurate molding in a layer-upon-layer accumulating manner, so as to obtain the required CSH / MBG composite bone cement bracket; improving the strength of the CSH / MBG composite bone cement bracket in a curing manner: soaking the cured bracket in anhydrous ethanol, and then drying for later use. According to the method, the prepared bioactive bone cement bracket has a three-dimensional-communicating and controllable macroporous structure, is high in mechanical strength and can be used for promoting the propagation, differentiation and osteogenesis of human bone marrow mesenchym stem cells.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a bone tissue engineering support, in particular to a preparation method of a composite bone cement support. Background technique [0002] The repair of bone defects, especially large bone defects caused by infection, resection surgery and genetic deformities, still faces great clinical challenges. At present, repairing the defect with bone tissue engineering scaffold is considered to be one of the effective methods to solve related problems. However, bone tissue engineering scaffolds need to have a three-dimensional interconnected porous structure, good mechanical support performance, degradability and biological activity. How to prepare bone tissue engineering scaffolds that meet the above requirements is a hot and difficult research topic. Calcium sulfate (calcium sulfate hemihydrate, CSH) is a clinically used bone cement material with hydraulic hardness and good biocompatibil...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/10A61L27/02B33Y10/00
CPCA61L27/56A61L27/025A61L27/10A61L2430/02B33Y10/00
Inventor 朱钰方裴鹏杜晓宇
Owner UNIV OF SHANGHAI FOR SCI & TECH
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