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Double-layer emulsified liquid drop, medicine carrying micro-sphere, method for preparing same and device for preparing double-layer emulsified liquid drop

A technology for preparing a device and an emulsion, which is applied in the fields of biomedical materials and microfluidics, can solve the problems of cumbersome operation, high cost, complicated device structure, etc., and achieve the effects of increasing safety, preventing sudden release, and controlling drug release.

Pending Publication Date: 2016-12-14
ENERGY RES INST OF SHANDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the shortcomings of the existing double-layer emulsified droplets and drug-loaded microspheres in the preparation process, the device structure is complicated, the operation is cumbersome, and the cost is high. The present invention provides a double-layer emulsified droplet, drug-loaded microspheres and a preparation method and device thereof. The operation process is simple, the device can be combined flexibly, and the cost is low. Microspheres with a particle size range of 0-1000 microns can be prepared, and the particle size uniformity of the microspheres is good, and the drug can be loaded efficiently, which solves the problems existing in the existing microsphere preparation process. Problems such as uncontrollable particle size, inability to synchronize curing, incomplete drug loading, etc.

Method used

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  • Double-layer emulsified liquid drop, medicine carrying micro-sphere, method for preparing same and device for preparing double-layer emulsified liquid drop
  • Double-layer emulsified liquid drop, medicine carrying micro-sphere, method for preparing same and device for preparing double-layer emulsified liquid drop
  • Double-layer emulsified liquid drop, medicine carrying micro-sphere, method for preparing same and device for preparing double-layer emulsified liquid drop

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Embodiment 1, the preparation of polyvinyl alcohol and sodium alginate mixed aqueous solution

[0078] Weigh 10 grams of polyvinyl alcohol solid particles and add 90 grams of distilled water, stir and dissolve evenly under the condition of 75-80 ° C to form a transparent liquid, and obtain a 10% by mass polyvinyl alcohol aqueous solution.

[0079] Weigh 5 grams of sodium alginate solid particles and add 95 grams of distilled water, stir evenly at room temperature and dissolve into a transparent liquid to obtain a 5% by mass sodium alginate aqueous solution.

[0080] According to the mass fraction, the above aqueous solution of polyvinyl alcohol and sodium alginate was prepared into a mixed aqueous solution of polyvinyl alcohol and sodium alginate with final concentrations of 1% and 0.5%, respectively.

[0081] The continuous phase fluid used in the embodiment is paraffin oil containing 2% EM90. Weigh 98 grams of paraffin oil and add 2 grams of EM90 to obtain a 2% mass p...

Embodiment 2

[0087]A preparation device for double-layer emulsified droplets, which is composed of a first-stage microchannel and a second-stage microchannel in series;

[0088] The first-stage microchannel is a cross-shaped microchannel A, a T-shaped microchannel B, a Y-shaped microchannel C or a co-flow microchannel D;

[0089] Described second-level microchannel includes two types of microchannels of Class A or Class B;

[0090] The Class A second-stage microchannel includes a coaxially connected discrete phase fluid channel, a continuous phase fluid channel 5 and a collection channel 6, the discrete phase fluid channel and the collection channel 6 are nested in the continuous phase fluid channel 5, and the discrete phase One end of the fluid channel close to the collection channel 6 is tapered, and the discrete phase fluid channel is equally divided into a single-layer emulsified micro-droplet inlet channel 3 and a catalyst or curing agent channel 4 along the central axis;

[0091] De...

Embodiment 3

[0097] Embodiment 3, preparation of drug-loaded microspheres:

[0098] Selection of the first stage microchannel Figure 1A In the cross-shaped first-stage microchannel shown, the diameter of the internal phase fluid channel A2 is 150 microns, and the diameter of the interphase fluid channel A1 is 200 microns; the second-stage microchannel is selected Figure 2A In the class A second-stage microchannel shown, the diameter of the discrete phase fluid channel 5 is 250 microns, and the diameter of the continuous phase fluid channel 5 is 300 microns.

[0099] The mass percentage concentration of the mixed aqueous solution of polyvinyl alcohol and sodium alginate is 1.5% and 0.5% respectively, and the aqueous solution of the crosslinking agent is 50% by mass of glutaraldehyde aqueous solution. The polyvinyl alcohol aqueous solution and the glutaraldehyde aqueous solution are premixed according to the mass ratio of solute polyvinyl alcohol:crosslinking agent=3:2, and the aqueous ca...

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Abstract

The invention relates to double-layer emulsified liquid drop, a medicine carrying micro-sphere, a method for preparing the same and a device for preparing the double-layer emulsified liquid drop. The device comprises primary micro-channels and secondary micro-channels which are serially connected with one another. The primary micro-channels are cross-shaped micro-channels, T-shaped micro-channels, Y-shaped micro-channels or co-flowing micro-channels; the secondary micro-channels include type-A micro-channels or type-B micro-channels. Single-layer emulsified liquid drop is formed by internal-phase fluid and intermediate-phase fluid in the primary micro-channels, and the double-layer emulsified liquid drop is formed by the single-layer emulsified liquid drop, catalyst or curing agent solution and continuous-phase fluid at outlets of the secondary micro-channels. The double-layer emulsified liquid drop, the medicine carrying micro-sphere, the method and the device have the advantage that the device for preparing the double-layer emulsified liquid drop is simple in structure and flexible in adjustment, the particle sizes and the internal and external layer thicknesses of the emulsified liquid drop and the medicine carrying micro-sphere are easy to flexibly control, the double-layer emulsified liquid drop and the medicine carrying micro-sphere are low in preparation cost, the particle sizes of the double-layer emulsified liquid drop can be controlled, and the double-layer emulsified liquid drop is wide in particle size adjustable range.

Description

technical field [0001] The invention relates to a double-layer emulsified droplet, a drug-loaded microsphere and a preparation method and device thereof, belonging to the technical fields of biomedical materials and microfluidics. Background technique [0002] Water-in-oil-in-water or oil-in-water-in-oil double-layer emulsified microdroplets, and drug-loaded microspheres prepared using them as templates are widely used in biomedical materials, drug research and development, and other fields. The existing preparation methods mainly adopt traditional large-scale mechanical stirring, emulsification-crosslinking, composite emulsion-solvent volatilization, emulsification-gel, reverse suspension polymerization and other technologies. The first step is to generate double-layer emulsified micro-droplets, and then through Solvent volatilization, drying and other methods to generate microsphere products. The traditional preparation method lacks the precise control of the size of the ...

Claims

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Application Information

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IPC IPC(8): A61J3/00A61K9/50A61K47/34A61K47/42A61K47/36A61K47/32
CPCA61K47/10A61K47/34A61J3/00A61K9/5026A61K9/5036A61K9/5057
Inventor 李艳王立秋王建梅王雪莹孔湉湉许敏
Owner ENERGY RES INST OF SHANDONG ACAD OF SCI
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