A compound, its preparation method and its use in the synthesis of Buvaracetam

Abstract

The application provides a compound of formula I and a preparation method thereof. The application also provides the use of the compound of formula I for synthesizing buvaracetam and the synthesis method. The raw materials involved in the method described in this application are easy to obtain and cheap, and can prepare brivaracetam with high optical purity.

Description

technical field

[0001] The application relates to the field of drug synthesis, in particular, to a compound, its preparation method and its use in synthesizing buvaracetam. The present application also relates to a method for synthesizing Buvaracetam. Background technique

[0002] Epilepsy is a common disease of the nervous system, with an incidence rate of 0.6% to 1.1% in the population, and 60% to 70% of patients will still have seizures while taking antiepileptic drugs, causing some patients to stop drug treatment by themselves. At present, there are more than 6 million epilepsy patients in my country, and 650,000 to 700,000 new epilepsy patients are diagnosed every year, and about 25% of them are refractory epilepsy. Although great progress has been made in the diagnosis and treatment of epilepsy, the number of patients with intractable epilepsy is increasing day by day. Generalized intractable epilepsy refers to epilepsy and epilepsy syndromes that cannot be terminate...

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