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Process method for alcohol extraction of palmatine

A process method and alcohol extraction technology, applied in the field of plant extraction, can solve the problems of large sewage treatment volume, large amount of salt used for salting out, and long operation time, so as to improve the extraction rate, facilitate filtration, and reduce the number of times of cleaning the filter screen. Effect

Inactive Publication Date: 2017-01-25
西安天一生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current mainstream extraction process of palmatine is the acid water cold extraction process, which has the disadvantages of low extraction rate, long operation time, difficult filtration, large amount of salt used for salting out, and large amount of sewage treatment.

Method used

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  • Process method for alcohol extraction of palmatine
  • Process method for alcohol extraction of palmatine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The present invention comprises the following steps:

[0034] 1) Extract 200 g of the vine root powder with alcohol for 4 times, the extraction temperature is controlled at 60° C. for 2 hours each time, and the combined filtrate is cooled and then filtered to remove insoluble impurities to obtain the filtrate. 15 (3000ml) times, the alcohol is methanol;

[0035] 2) the filtrate is evaporated to dryness to obtain a solid residue, and the solid residue is eluted with an acid solution to obtain an eluent. The volume of the acid solution is 2 times (300ml) of the solid residue quality, and the acid solution is sulfuric acid. The volume concentration of the liquid is 0.5%;

[0036] 3) After filtering the eluent, adjust the base, control the pH value at 9, leave it to stand until the insoluble matter is precipitated, then filter, carry out salting-out on the filtrate, filter to obtain the crude product after salting-out, use sodium hydroxide for base adjustment, the concentr...

Embodiment 2

[0039] The present invention comprises the following steps:

[0040] 1) Extract 200 g of yellow vine powder with alcohol for 3 times, the extraction temperature is controlled at 70° C. for 3 hours each time, the combined filtrate is cooled and filtered to remove insoluble impurities to obtain filtrate. The total volume of alcohol is 1 / 2 of the quality of yellow vine powder 18 times (3600ml), the alcohol is ethanol;

[0041] 2) The filtrate was evaporated to dryness to obtain a solid residue, and the solid residue was eluted with an acid solution to obtain an eluent, the amount of the acid solution was 350ml, the acid solution was hydrochloric acid, and the volume concentration of the acid solution was 0.6%;

[0042] 3) After filtering the eluent, adjust the base, the pH value is controlled at 9, and the base adjustment adopts potassium hydroxide, and the concentration is 40%; leave it to stand and filter after insoluble matter is separated out, and the filtrate is salted out, ...

Embodiment 3

[0045] The present invention comprises the following steps:

[0046] 1) Extract 200 g of yellow vine powder with alcohol for 3 times, the extraction temperature is controlled at 50° C., for 2 hours each time, the combined filtrate is cooled and filtered to remove insoluble impurities to obtain filtrate. The volume of alcohol is 15% of the quality of yellow vine powder. times (3000ml), the alcohol adopts isopropanol;

[0047] 2) The filtrate was evaporated to dryness to obtain a solid residue, and the solid residue was eluted with an acid solution to obtain an eluent, the amount of the acid solution was 500ml, the acid solution was acetic acid, and the volume concentration of the acid solution was 0.7%;

[0048] 3) After filtering the eluent, adjust the base, control the pH value at 10, leave it to stand until the insoluble matter is precipitated, and then filter, then salt the filtrate, the volume of the filtrate is about 550ml, add 50g of sodium chloride for salting out for 3...

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Abstract

The invention discloses a process method for alcohol extraction of palmatine. According to the process method, the palmatine extracting rate is increased, the extraction time is shortened, the production efficiency is improved, filtrate is easy to filter, the labor intensity is reduced, the use amount of acid water is reduced, and therefore, the use amount of salting out raw materials and the sewage treatment amount are reduced. According to the technical scheme, the process method comprises the following steps of: extracting common fibraurea stem powder with alcohol, combining filtrate, cooling, and filtering to remove insoluble impurities; drying the filtrate through steaming, and eluting residues after the steaming with acid liquid; filtering eluant, regulating the alkali degree, standing until the insoluble impurities are separated, filtering, adding sodium chloride into the filtrate, carrying out salting out, and filtering to obtain a crude product; and heating to dissolve the crude product into ethanol, immediately filtering to remove the insoluble impurities, after the filtrate is cooled, slowly adding concentrated hydrochloric acid, after palmatine hydrochloride is separated out, filtering, and drying, so as to obtain the product.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and relates to a method for purifying palmetine, in particular to a process for alcohol-extracting palmetine. Background technique [0002] Huangtengsu (rheumatin) is a pure natural herbal medicine independently developed by our country. It has been included in the Chinese Pharmacopoeia. Inflammation and enhance the body's immunity. It is used for gynecological inflammation, bacillary dysentery, enteritis, respiratory tract and urinary tract infection, surgical infection, and conjunctivitis. 1. Gynecological inflammation, acute and chronic pelvic inflammatory disease, acute and chronic adnexitis, cervical erosion, endometritis, fungal vaginitis, puerperal infection, etc. 2. Urinary tract infection; 3. Surgical infection, conjunctivitis; 4. Respiratory tract infection and other general medicine. It has an inhibitory effect on fungi, especially against Candida albicans, gypsum-like hai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/03
CPCC07D455/03
Inventor 姚卫帮
Owner 西安天一生物技术股份有限公司
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