Composite fiber containing aggregation-induced luminescent molecules, preparation method thereof and application thereof

A technology of aggregation-induced luminescence and composite fibers, which can be used in medical preparations with non-active ingredients, fiber processing, organic non-active ingredients, etc., can solve problems such as fluorescence quenching, achieve good repeatability, a wide variety, and facilitate long-term observation. Effect

Inactive Publication Date: 2017-02-08
SOUTH CHINA UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to endow the fiber material with the ability of fluorescence imaging, that is, the performance of developing and imaging under a fluorescence microscope or a confocal microscope, and at the same time in order to overcome the shortcomings and deficiencies of the fluorescence quenching of the traditional ACQ fluorescent molecules when the concentration is too large, the purpose of the present invention is to Provide a composite fiber containing aggregation-induced emission molecules (AIE)

Method used

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  • Composite fiber containing aggregation-induced luminescent molecules, preparation method thereof and application thereof
  • Composite fiber containing aggregation-induced luminescent molecules, preparation method thereof and application thereof
  • Composite fiber containing aggregation-induced luminescent molecules, preparation method thereof and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Mix polylactic acid (PLA) and dichloromethane (DCM) in a mass ratio (1:8) (PLA molecular weight 500,000), and then add AIE molecule hexaphenylsilole (HPS) (mass ratio PLA / HPS=5:1 ), at a speed of 100r / min, stirred for 48h, mixed evenly, to obtain a spinning solution; put the spinning solution into an injection device, electrospun, collected by a collection device, dried (naturally dried at 25°C for 24h), and obtained a solution containing Composite fibers of AIE (composite fibers containing aggregation-induced luminescent molecules); the conditions of electrospinning are: the spinning ambient temperature is 15°C, the relative humidity is 15%, the injection flow rate of the spinning solution is 0.5mL / h, and the spinning is normal. The voltage is 40kV, and the glass sheet is attached to the flat plate for grounding. The distance between the needle in the injection device and the collecting plate is 15cm. In addition, a grounding needle (point electrode) is set 2cm behind t...

Embodiment 2

[0055] Add polyurethane (PU) to a mixed solvent of tetrahydrofuran (THF) and N,N-dimethylformamide (DMF) (mass ratio THF / DMF=1:1) to prepare a polymer with a mass fraction of polyurethane of 15%. solution, then add AIE hexaphenylsilole (HPS) (mass ratio PU / HPS=10:1), mechanically stir for 6h (stirring speed is 900r / min), fully mix to obtain spinning solution; The solution was loaded into an injection device, electrospun, collected by a collection device, and dried (drying in a vacuum oven at 70°C for 4 hours) to obtain a composite fiber containing AIE (composite fiber containing aggregation-induced luminescent molecules); the conditions of electrospinning It is: the spinning voltage is 20kV, the ambient temperature is 50°C, the relative humidity is 99%, nitrogen is used as the protective gas, the spinning solution injection flow rate is 10mL / h, and aluminum foil is attached to a drum with a diameter of 20cm as the spinning device (Drum rotation speed 3000r / min), the drum is co...

Embodiment 3

[0057] Preparation of coaxial electrospinning solution: take polylactic acid (PLA) and polyvinylpyrrolidone (PVP) (mass ratio = 9:1), and use dichloromethane (DCM) as a solvent to prepare a high concentration of solute with a total mass concentration of 6%. Molecular mixing solution, add tetraphenylethylene (TPE) (mass ratio: macromolecule / TPE=20:1); mechanically stir for 12h (stirring speed is 300r / min) to obtain shell spinning solution; take polylactic acid (PLA) and polyethylene glycol (PEG) (PLA: PEG mass ratio = 5: 1), using tetrahydrofuran (THF) as a solvent to prepare a polymer solution with a total solute mass concentration of 15%, adding 2,3-dicyano- 5,6-bis(4'-diphenyl-biphenyl-4-tertiary amino)pyrazine (CAPP) (mixed polymer / CAPP=20:1); mechanical stirring for 12h (stirring speed: 300r / min) to obtain Core layer spinning solution; respectively put the shell layer spinning solution and the core layer spinning solution into the injection device of the coaxial electrospi...

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Abstract

The invention belongs to the field of high polymer materials, and discloses a composite fiber containing aggregation-induced luminescent molecules, a preparation method thereof and an application thereof. The preparation method of the composite fiber comprises the steps of adding aggregation-induced luminescent molecules into a high polymer material solution or a solution of a high polymer material and a carrier, uniformly mixing the solution, and preparing the composite fiber through the electrostatic spinning process. The composite fiber containing aggregation-induced luminescent molecules has multiple types of AIE, and is strong in fluorescence intensity. Therefore, the composite fiber can meet the requirements of different fluorescent staining operations. The preparation method provided by the invention is simple, high in production efficiency, and good in repeatability. The composite fiber containing aggregation-induced luminescent molecules can be applied in the fields of cell positioning and imaging, fiber microstructure observation, fiber drug loading and the like.

Description

technical field [0001] The invention belongs to the field of macromolecular materials, and relates to a composite fiber containing aggregation-induced luminescent molecules, a preparation method and application thereof. [0002] technical background [0003] Electrospinning is a simple, effective, and continuous spinning technology for preparing polymer ultrafine fibers. The average diameter of electrospun fibers is generally between a dozen nanometers and tens of microns. It is widely used in the field of materials, especially in the field of polymer materials. The advantages of electrospinning are: 1. The device is simple and the process parameters are easy to control. 2. The raw materials for spinning come from a wide range of sources, such as single polymer, polymer mixture, polymer / inorganic material mixture, etc. 3. The shape, diameter and topology of the fibers are controllable. Electrospinning technology is the only existing method that is expected to achieve mass ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/92D01F6/94D01F8/14D01F8/10D01F8/16D01F1/10D01D5/00A61L27/18A61L27/16A61L27/54A61L27/50A61K47/34A61K47/32A61K47/22A61K47/06
CPCA61K47/32A61K47/34A61L27/14A61L27/50A61L27/54D01D5/00D01F1/10D01F6/92D01F6/94D01F8/10D01F8/14D01F8/16A61K47/06A61K47/22A61L27/16A61L27/18D01D5/003C08L67/04C08L75/04C08L71/00C08L39/06
Inventor 王林格朱玥李卫昌贾毅凡秦安军唐本忠潘凌翔
Owner SOUTH CHINA UNIV OF TECH
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