Veterinary compound florfenicol injection and preparation method thereof

A technology of compound florfenil and florfenicol is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve the problems of low bioavailability, poor acupuncture, The problem of high irritation, etc., achieves the effect of simple preparation process, enhanced efficacy and low residue.

Inactive Publication Date: 2017-02-22
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Flunixin meglumine does not affect gastrointestinal motility in horses but may improve hemodynamics in animals with septic shock
[0004] In recent years, most of the florfenicol injections on the market are unilateral preparations, with poor effect, large d

Method used

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  • Veterinary compound florfenicol injection and preparation method thereof
  • Veterinary compound florfenicol injection and preparation method thereof
  • Veterinary compound florfenicol injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Add 50g of florfenicol to 300ml of isopropyl myristate, heat at 50°C, stir to dissolve, let cool for later use, and obtain solution ①; add 5g of flunixin meglumine and 0.5g of anhydrous sodium sulfite into 50ml of water for injection , stir and dissolve to obtain solution ②; mix the above two solutions ① and ②, stir evenly, then add polyethylene glycol stearate-15 in the prescribed amount, stir evenly, and finally use polyethylene glycol stearate Dilute ester-15 to 1L, filter, and reserve; the semi-finished product should be inspected, and after passing the inspection, it should be filled with nitrogen and sterilized at 105°C for 30 minutes to obtain the compound florfenicol injection.

Embodiment 2

[0021] Add 100g of florfenicol to 350ml of isopropyl myristate, heat at 50°C, stir to dissolve, let cool for later use, and obtain solution ①; add 10g of flunixin meglumine and 1g of anhydrous sodium sulfite into 75ml of water for injection, Stir and dissolve to obtain solution ②; mix the above two solutions ① and ②, stir evenly, then add polyethylene glycol stearate-15 in the prescribed amount, stir evenly, and finally use polyethylene glycol stearate Dilute ester-15 to 1L, filter, and set aside; the semi-finished product should be inspected. After passing the inspection, fill the seal with nitrogen gas, and sterilize at 105°C for 30 minutes to obtain the compound florfenicol injection.

Embodiment 3

[0023] Add 150g of florfenicol to 400ml of isopropyl myristate, heat at 50°C, stir to dissolve, let cool for later use, and obtain solution ①; add 15g of flunixin meglumine and 1.5g of anhydrous sodium sulfite into 100ml of water for injection , stir and dissolve to obtain solution ②; mix the above two solutions ① and ②, stir evenly, then add polyethylene glycol stearate-15 in the prescribed amount, stir evenly, and finally use polyethylene glycol stearate Dilute ester-15 to 1L, filter, and reserve; the semi-finished product should be inspected, and after passing the inspection, it should be filled with nitrogen and sterilized at 105°C for 30 minutes to obtain the compound florfenicol injection.

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Abstract

The invention discloses a veterinary compound florfenicol injection, and belongs to the field of veterinary preparations. Every 1 L of the injection comprises 50 g to 300 g of florfenicol, 5 g to 30 g of flunixin meglumine, 300 ml to 600 ml of isopropyl myristate, 150 ml to 450 ml of polyethylene glycol stearate, 0.5 g to 3 g of anhydrous sodium sulfite and 50 ml to 200 ml of water for injection. A preparation method is disclosed. The veterinary compound florfenicol injection has an obvious effect on poultry and livestock bacteriosis, morbus virosus and parasitic disease concurrency prevention and treatment and secondary bacterium infection, and especially effectively treats pig infective pleuropneumonia necrotic enteritis, piglet's yellow-white dysentery, swine enzootic pneumonia, atrophic rhinitis, metritis-mastistis-agalactia, clostridial enteritis of piglets, postpartum infection, haemophilus parasuis and the like. The preparation process is simple, good stability is achieved, cost is low, the water for injection is used for replacing part of an organic solvent, local analgesic does not need to be added, good liquidity and better needle passing performance are achieved, and irritation is reduced during injection.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a veterinary compound florfenicol injection and a preparation method thereof. Background technique [0002] In recent years, with the improvement of people's living standards and the development of animal husbandry, the stock of livestock and poultry has increased year by year, followed by various respiratory and digestive tract diseases of livestock and poultry, which have caused huge losses to the animal husbandry. At present, there is no ideal drug with broad-spectrum therapeutic effect for the treatment of such diseases in the market. Clinically, drugs such as gentamicin sulfate and enrofloxacin hydrochloride injection are generally used for treatment, but drug resistance is prone to occur and the effect is not obvious. [0003] Florfenicol belongs to the broad-spectrum antibacterial drug of amido alcohols, and has strong antibacterial activity against a variety o...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/44A61K31/165A61K47/14A61K47/02A61P31/04
CPCA61K9/0019A61K9/08A61K31/165A61K31/44A61K47/02A61K47/14A61K2300/00
Inventor 崔亮亮张瑞丽邱梅王苹苹谢龙霄郝智慧
Owner QINGDAO AGRI UNIV
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