Veterinary compound florfenicol injection and preparation method thereof

Abstract

The invention discloses a veterinary compound florfenicol injection, and belongs to the field of veterinary preparations. Every 1 L of the injection comprises 50 g to 300 g of florfenicol, 5 g to 30 g of flunixin meglumine, 300 ml to 600 ml of isopropyl myristate, 150 ml to 450 ml of polyethylene glycol stearate, 0.5 g to 3 g of anhydrous sodium sulfite and 50 ml to 200 ml of water for injection. A preparation method is disclosed. The veterinary compound florfenicol injection has an obvious effect on poultry and livestock bacteriosis, morbus virosus and parasitic disease concurrency prevention and treatment and secondary bacterium infection, and especially effectively treats pig infective pleuropneumonia necrotic enteritis, piglet's yellow-white dysentery, swine enzootic pneumonia, atrophic rhinitis, metritis-mastistis-agalactia, clostridial enteritis of piglets, postpartum infection, haemophilus parasuis and the like. The preparation process is simple, good stability is achieved, cost is low, the water for injection is used for replacing part of an organic solvent, local analgesic does not need to be added, good liquidity and better needle passing performance are achieved, and irritation is reduced during injection.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a veterinary compound florfenicol injection and a preparation method thereof. Background technique [0002] In recent years, with the improvement of people's living standards and the development of animal husbandry, the stock of livestock and poultry has increased year by year, followed by various respiratory and digestive tract diseases of livestock and poultry, which have caused huge losses to the animal husbandry. At present, there is no ideal drug with broad-spectrum therapeutic effect for the treatment of such diseases in the market. Clinically, drugs such as gentamicin sulfate and enrofloxacin hydrochloride injection are generally used for treatment, but drug resistance is prone to occur and the effect is not obvious. [0003] Florfenicol belongs to the broad-spectrum antibacterial drug of amido alcohols, and has strong antibacterial activity against a variety o...

AI Technical Summary

Problems solved by technology

Flunixin meglumine does not affect gastrointestinal motility in horses but may improve hemodynamics in animals with septic shock

[0004] In recent years, most of the florfenicol injections on the market are unilateral preparations, with poor effect, large dosage, high residue and low bioavailability, and almost all the solvents of florfenicol injections are organic solvents. Subcutaneous injection is very irritating, and the needle penetration is not good, and local analgesic drugs are needed when using it

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