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A composition of ginsenosides and fluconazole against Candida albicans drug-resistant strains and its application

A technology of ginseng stem and leaf saponins and Candida albicans, which is applied in the direction of antifungal agents, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve the problems of drug resistance, curative effect reduction, and cytotoxic side effects of the body

Active Publication Date: 2019-07-09
SHANGHAI TONGJI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Fluconazole is an antifungal drug that interferes with the lipid synthesis of fungal cell membranes, but it is prone to drug resistance and greatly reduces the curative effect, and because the cell membrane components of fungal cells and human host cells are similar or have many common metabolic characteristics, While using fluconazole antifungal, it has a certain degree of toxic and side effects on human body cells
At present, there is no report on the use of fluconazole and traditional Chinese medicine in combination with antifungal agents, especially the combination of fluconazole and ginsenosides to reduce its toxic side effects and drug resistance.

Method used

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  • A composition of ginsenosides and fluconazole against Candida albicans drug-resistant strains and its application

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Experimental program
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Embodiment 1

[0020] 1 Experimental materials

[0021] 1.1 Source of strain

[0022] The 19 clinical isolates of Candida came from the Department of Dermatology, Shanghai Tongji Hospital, including sputum (7 strains), vaginal secretions (5 strains), feces (4 strains), and urine (3 strains). The drug-sensitive quality control strains were Candida parapsilosis ATCC22019 and Candida krusei ATCC6258 specified by CLSI (the Clinical and Laboratory Standards Institute).

[0023] 1.2 Main reagents and instruments

[0024] Dimethyl sulfoxide (Amerseo, USA), RPMI 1640 powder (Gibco, USA), Sabouraud medium raw materials (Sinopharm Chemical Reagent Co., Ltd. Shanghai Branch), electronic analytical balance (MettlerT01edo, Switzerland), electric thermostat incubator (Shanghai Jinghong Experimental Equipment Co., Ltd.), biological safety cabinet (Likang Biotechnology Co., Ltd.).

[0025] 1.3 Test drugs

[0026] Fluconazole (FLC) powder (content 99.9%) was purchased from Shanghai Sanwei Pharmaceutical ...

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Abstract

The invention relates to a panax pseudo ginseng leaves extract and fluconazole composition of an anti-candida albicans drug-resistant strain and application thereof. The composition is prepared from fluconazole and the panax pseudo ginseng leaves extract, wherein the weight ratio of the fluconazole to the panax pseudo ginseng leaves extract is 1 to 0.25-8. The fluconazole and the panax pseudo ginseng leaves extract are used in a combined mode and have the remarkable synergic antibacterial effect on the candida albicans, meanwhile an antifungal effect is remarkably strengthened, and the composition clinically has a wide application prospect.

Description

technical field [0001] The invention relates to a pharmaceutical composition related to traditional Chinese medicine extracts, in particular to a composition of ginsenosides and fluconazole against drug-resistant strains of Candida albicans and its application. Background technique [0002] Candida is a clinically important pathogenic fungus. Candida has a wide spectrum of pathogenic diseases and can cause infections of the skin, mucous membranes and internal organs. In recent years, due to the increase of tumors and AIDS patients, the incidence of Candida infection is on the rise. In a survey in the United States, it was found that nosocomial infections caused by Candida ranked fourth. Candida albicans is a common pathogen causing clinical deep fungal infection, accounting for more than 80%. Traditional antifungal drugs have a low clinical cure rate, are prone to drug resistance, and have obvious adverse reactions to some drugs. According to figures from the National Bur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4196A61K36/258A61P31/10
CPCA61K31/4196A61K36/258A61K2300/00
Inventor 黄欣K.乌玛闻轶旸B.鹏程
Owner SHANGHAI TONGJI HOSPITAL