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Method for extracting salidroside from rhodiola

A technology of salidroside and rhodiola rosea, which is applied in the field of salidroside extraction, can solve problems such as unstable product quality, long processing time, and sharp decrease in membrane flux, so as to improve the use value and scope of use, shorten the Extraction time, the effect of reducing the difficulty of extraction

Inactive Publication Date: 2017-02-22
乌鲁木齐上善元生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Column chromatography can obtain relatively high-purity salidroside, but the loss of active ingredients is serious and the yield is too low, so it is only suitable for the preparation of trace standards; during the use of ultrafiltration purification ultrafiltration membranes, membrane fouling is easy to cause The flux of the membrane drops sharply, and a large amount of alkali and acid are used in the membrane cleaning process, and the separation selectivity is poor, and the product quality is unstable; while the ethanol precipitation method removes impurities, the obtained dry extract has a high viscosity and is easy to absorb moisture , brings inconvenience to the post-process operation, this method consumes a lot of alcohol, has high cost, and takes a long time to process; the macroporous resin adsorption method is more commonly used, but only relying on a separation method of macroporous adsorbent resin, the obtained Rhodiola Glycoside product purity is still low

Method used

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  • Method for extracting salidroside from rhodiola

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1. Put the rhizome of 2 kg of fresh Rhodiola rosea into 0.2% hydrochloric acid and soak for 10 minutes, and wash the soaked raw materials until the residual acid content is not more than 0.4g / L, and wash the fresh Rhodiola rosea after washing. The rhizome of Rhodiola rosea is cooled to 8°C, and the cooled fresh rhizome of Rhodiola rosea is squeezed with a screw juicer, and the squeezed juice is sequentially used with a 0.5 μm microfiltration membrane and a 0.01 μm ultrafiltration membrane Filtration is carried out, and the filter residue obtained by filtration is combined with the residue obtained by pressing to obtain residue material.

[0042] Two, adopt the method that ethanol leaching and ultrasonic extraction combine to extract described slag material, obtain extracting liquid:

[0043] Ethanol leaching includes two steps of primary leaching and secondary leaching in turn: put the slag into the extraction tank, add 70% ethanol of the first mass to the extraction ta...

Embodiment 2

[0053] 1. Put the rhizome of 2 kg of fresh Rhodiola rosea into 0.2% hydrochloric acid and soak for 10 minutes, and wash the soaked raw materials until the residual acid content is not more than 0.4g / L, and wash the fresh Rhodiola rosea after washing. The rhizome of Rhodiola rosea is cooled to 12°C, and the cooled fresh rhizome of Rhodiola rosea is squeezed with a screw juice extractor, and the squeezed juice is sequentially used with a 0.3 μm microfiltration membrane and a 0.005 μm ultrafiltration membrane Filtration is carried out, and the filter residue obtained by filtration is combined with the residue obtained by pressing to obtain residue material.

[0054] Two, adopt the method that ethanol leaching and ultrasonic extraction combine to extract described slag material, obtain extracting solution:

[0055] Ethanol leaching includes two steps of primary leaching and secondary leaching in turn: put the slag into the extraction tank, add the first mass of 70% ethanol to the ...

Embodiment 3

[0065] 1. Put the rhizome of 2 kg of fresh Rhodiola rosea into 0.2% hydrochloric acid and soak for 10 minutes, and wash the soaked raw materials until the residual acid content is not more than 0.4g / L, and wash the fresh Rhodiola rosea after washing. The rhizome of Rhodiola rosea is cooled to 8°C, and the cooled fresh rhizome of Rhodiola rosea is squeezed with a screw juice extractor, and the squeezed juice is sequentially used with a 0.1 μm microfiltration membrane and a 0.005 μm ultrafiltration membrane Filtration is carried out, and the filter residue obtained by filtration is combined with the residue obtained by pressing to obtain residue material.

[0066] Two, adopt the method that ethanol leaching and ultrasonic extraction combine to extract described slag material, obtain extracting liquid:

[0067] Ethanol leaching includes two steps of primary leaching and secondary leaching in turn: put the slag into the extraction tank, add 70% ethanol of the first mass to the ext...

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Abstract

The invention discloses a method for extracting salidroside from rhodiola. The method comprises the following steps: cooling fresh rhizome of rhodiola to 8-12 DEG C, squeezing the fresh rhizome of rhodiola with a spiral juicer, filtering juice obtained by squeezing through sequentially using of a microfiltration membrane and an ultrafiltration membrane, combining filter residues obtained by filtration with residues obtained by squeezing to obtain a residue material; extracting the residue material by using a method of combining ethanol extraction with ultrasonic extraction to obtain extract; filtering the extract, adsorbing filtrate with a macroporous resin, and collecting eluent rich in salidroside; performing centrifugation, separation concentration and three-stage reverse osmosis concentration on the eluent rich in salidroside to obtain extractum, and drying the extractum through a microwave method to obtain salidroside powder. The method for extracting salidroside provided by the invention has advantages of high yield, low cost, low energy consumption and high purity.

Description

technical field [0001] The invention relates to the technical field of salidroside extraction, more specifically, the invention relates to a method for extracting salidroside from Rhodiola rosea. Background technique [0002] Rhodiola (Rhodiola) is a perennial herb or subshrub belonging to Rhodiola in the Sedum family. It is one of the rare medicinal plants and is known as "Plateau Ginseng". There are about 90 species of this genus in the world, and more than 70 species are distributed in my country. They are mainly produced in North China, Northeast China, Southwest China, Northwest China and Central China. Its chemical components mainly include flavonoids, tyrosol, salidroside, sitosterol, organic acids, volatile oil, polysaccharide, fat, protein, etc. Among them, salidroside and its aglycone tyrosol are the main active ingredients of Rhodiola rosea, and are also the most important indicators for evaluating Rhodiola rosea and its extracts. Modern pharmacological studies ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/18C07H1/08
CPCC07H15/18C07H1/08
Inventor 陈建国刘淼
Owner 乌鲁木齐上善元生物科技有限公司
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