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Self-healing polyanion-chitosan quaternary ammonium salt hydrogel and use thereof

A technology of chitosan quaternary ammonium salt and polyanion, applied in the field of polymer hydrogel, can solve the problems that the shape cannot be changed at will, unfavorable transplantation, etc., and achieve the effect of low price, abundant material sources, and good biocompatibility

Active Publication Date: 2017-03-01
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, calcium alginate is commonly used as the gel material, but once the hydrogel is prepared, its shape cannot be changed at will, which is not conducive to subsequent applications such as transplantation.

Method used

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  • Self-healing polyanion-chitosan quaternary ammonium salt hydrogel and use thereof
  • Self-healing polyanion-chitosan quaternary ammonium salt hydrogel and use thereof
  • Self-healing polyanion-chitosan quaternary ammonium salt hydrogel and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1) Prepare sodium alginate and chitosan quaternary ammonium salt solutions, the concentrations are respectively 20g / L and 40g / L, and the solvent is deionized water. Sodium alginate has a molecular weight of 430kDa and a G fragment content of 35%. The degree of substitution of chitosan quaternary ammonium salt is 85%, and the molecular weight is 78kDa.

[0031] (2) Add the chitosan quaternary ammonium salt solution into an equal volume of sodium alginate solution under shaking conditions, shake and mix well.

[0032] (3) Static precipitation for 2 hours to collect the product. The formed gels were stained with red basic fuchsin and blue methylene blue respectively, and the two cake-shaped gels with different colors were evenly divided into 4 parts, and rearranged according to the principle of staggered colors, so that the cut two pieces Gel close up. Thereafter, the gel state was observed at different times. The result is as figure 1 As shown, the boundaries of the...

Embodiment 2

[0034](1) Prepare carboxymethylcellulose sodium and chitosan quaternary ammonium salt solutions, the mass fraction is 20g / L, and the solvent is deionized water. The molecular weight of sodium carboxymethyl cellulose is 500kDa. The degree of substitution of chitosan quaternary ammonium salt is 85%, and the molecular weight is 78kDa.

[0035] (2) Add the chitosan quaternary ammonium salt solution into an equal volume of sodium alginate solution under shaking conditions, shake and mix well.

[0036] (3) Static precipitation collected the product for 2 hours, and carried out rheological analysis, such as figure 2 It is shown that by increasing the strain, the structure of the gel is destroyed, and the structure of the gel recovers rapidly after the stress is reduced, and the storage modulus recovers to more than 65% of its original value.

Embodiment 3

[0038] (1) Prepare sodium alginate and chitosan quaternary ammonium salt solutions, the concentrations are respectively 20g / L and 40g / L, and the solvent is deionized water. Sodium alginate has a molecular weight of 430kDa and a G fragment content of 35%. The degree of substitution of chitosan quaternary ammonium salt is 85%, and the molecular weight is 78kDa.

[0039] (2) Add the chitosan quaternary ammonium salt solution into an equal volume of sodium alginate solution under shaking conditions, shake and mix well.

[0040] (3) Static precipitation for 2 hours to collect the product. The formed gel was mixed with water-soluble methylene blue and oil-soluble rhodamine B respectively, and the final drug concentration was 0.1 g / L.

[0041] (4) Collect 1 mL of the gel and place it in 10 mL of phosphate buffer (pH=7.4). At 25°C, the two drugs both exhibit fast and then slow release behavior. The drug release reaches 50% in 24 hours, and the drug is released after 7 days. The con...

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Abstract

The invention discloses self-healing polyanion-chitosan quaternary ammonium salt hydrogel and its use in the field of pharmaceutical biology. A preparation method of the hydrogel comprises respectively preparing a polyanionic solution and a chitosan quaternary ammonium salt solution, fully mixing the solutions so that the solutions are spontaneously aggregated under electrostatic interaction and undergo a gelation reaction, and collecting solid precipitates so that the polyanion-chitosan quaternary ammonium salt hydrogel is obtained. The hydrogel raw materials have wide sources and low prices. The hydrogel has good biocompatibility and has self-healing properties and in the process of formation, an organic solvent and acid-base environments are avoided so that the above properties lay the foundation for use of the hydrogel in the field of biomedicines. The hydrogel can be used for drug and protein positioning delivery and has injectability and high adhesion. When being used in tissue regeneration scaffolds, the hydrogel has the advantages of mild preparation condition, controllable shape and high water content, and is a good extracellular matrix material.

Description

technical field [0001] The invention relates to a polymer hydrogel, in particular to a self-healing polyanion-chitosan quaternary ammonium salt composite hydrogel and application thereof. Background technique [0002] Polymer hydrogel is a three-dimensional network structure polymer that can absorb and retain a large amount of water. The chemical cross-linking or physical cross-linking structure inside it can only swell but not dissolve. Polymer hydrogel has excellent viscoelasticity, high water content and water retention rate, and good biocompatibility. It can be applied in the fields of agriculture, food engineering and biomedicine. However, due to the high water content of polymer hydrogel, it will be destroyed due to low strength when subjected to tensile or compressive stress, which is difficult to meet the needs of practical applications. [0003] Hydrogel materials with self-healing function are expected to solve the above problems and are suitable for long-term us...

Claims

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Application Information

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IPC IPC(8): C08J3/02C08L5/08C08L5/04C08L1/28
Inventor 马小军任英于炜婷谢红国郑会珍高梦
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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