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Acanthopanax composition, preparation and detection method

A technology of Acanthopanax, composition, applied in the field of pharmaceutical preparations, capable of solving problems such as the loss of active ingredients

Active Publication Date: 2017-03-08
HARBIN ZHENBAO PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method uses alcohol precipitation twice and macroporous adsorption resin to remove impurities, but it also causes the loss of active ingredients.

Method used

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  • Acanthopanax composition, preparation and detection method
  • Acanthopanax composition, preparation and detection method
  • Acanthopanax composition, preparation and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Example 1 An Acanthopanax senticosus composition and its preparation method and content determination

[0098] 1. Preparation method:

[0099] (1) Pre-treatment: After washing and crushing 1000g of Acanthopanax senticosus, add 6 times the volume of purified water to decoct for 2 hours, then separate the decoction; add 6 times the volume of purified water to decoct for 2 hours, then separate the decoction; Add 6 times the volume of ice, after cooling to room temperature, decocting for 2 hours, separate the decoction; then add 6 times the volume of ice, after cooling to room temperature, and decocting for 2 hours, separate the decoction; Liquid A;

[0100] (2) Lime sulfur treatment: When liquid A is cooled to below 40°C, add 20% by weight of lime milk to adjust the pH to 10.0, let it stand for 16 hours, and then adjust the pH to 5.0 with sulfuric acid , After stirring uniformly, let it stand for 16 hours, filter the supernatant, and concentrate the supernatant under reduced pr...

Embodiment 2

[0151] Example 2 A Acanthopanax senticosus composition and its preparation method and content determination

[0152] 1. Preparation method:

[0153] (1) Pre-treatment: After cleaning and crushing 1000g acanthopanax senticosus,

[0154] Add 10 times the volume of purified water to decoction for 3.5 hours, then separate the decoction; add 10 times the volume of purified water to decoct for 3.5 hours, then separate the decoction; add 10 times the volume of purified water to decoct for 3.5 hours, then separate the decoction; Then add 10 times the volume of ice, after cooling to room temperature, decocting for 3.5 hours, then separate the decoction; then add 10 times the volume of ice, after cooling to room temperature, decocting for 3.5 hours, then separate the decoction; Combine the decoction to obtain Liquid A;

[0155] (2) Lime sulfur treatment: When liquid A is cooled to below 28°C, add 20% by weight of lime milk to adjust the pH to 12.0, let stand for 20 hours, and then adjust the p...

Embodiment 3

[0161] Example 3 An Acanthopanax senticosus composition and its preparation method and content determination

[0162] 1. Preparation method

[0163] (1) Pretreatment: After washing and crushing 1000g of Acanthopanax senticosus, add 8 times the volume of purified water to decocting for 5 hours, then separate the decoction; add 8 times the volume of purified water to decocate for 5 hours, then separate the decoction; Add 8 times the volume of ice, after cooling to room temperature, decocting for 5 hours, then separate the decoction; then add 8 times the volume of ice, after cooling to room temperature, and decocting for 5 hours, then separate the decoction; Decoction to obtain liquid A;

[0164] (2) Lime sulfur treatment: When liquid A is cooled to below 35°C, add 20% by weight of lime milk to adjust the pH to 10.0, let it stand for 24 hours, and then adjust the pH to 5.5 with sulfuric acid After stirring uniformly, let it stand for 30 hours, filter the supernatant liquid, and concen...

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Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to an acanthopanax composition, a preparation containing the acanthopanax composition and a detection method thereof. The acanthopanax composition contains eleutheroside of 31-167 mg / g, total flavonoids of 11-199 mg / g, total sugar of 224-736 mg / g and total inorganic salt of 20-173 mg / g. The detection method includes detection of (1) total glycosides, (2) the total sugar, (3) the total flavonoids, (4) total inorganic cations, (5) total inorganic anions and (6) total solids. The acanthopanax composition and the injection provided have more balanced components and obvious effect in lowering blood sugar, blood fat and the like, the efficacy of the acanthopanax composition is better than that of the prior art and the toxicity is relatively smaller and relatively safer.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical preparations, and specifically relates to an Acanthopanax senticosus composition, a preparation containing the same, and a detection method thereof. Background technique [0002] Eleutherococcus senticosus (Latin scientific name: Eleutherococcus senticosus), aliases: Eleutherococcus senticosus, Eleutherococcus senticosus . Its roots and rhizomes can be used as medicine. It has the effects of invigorating the qi, invigorating the spleen, tonifying the kidneys, soothing the nerves, promoting blood circulation and removing blood stasis. The Compendium of Materia Medica records that Acanthopanax senticosus can "replenish energy and essence, improve eyesight and reduce qi", and can "replenish five labor seven" Injury, long-term service, light body and endurance", often used to treat spleen and kidney yang deficiency, physical weakness, fatigue, loss of appetite, waist and knee pain, insomnia and dreams. Mode...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61P3/06A61P3/10A61P15/00G01N21/31
CPCA61K9/0019A61K9/08A61K36/254A61K2236/331A61K2236/39A61K2236/51A61K2236/53G01N21/31
Inventor 方同华项彦华徐秀杰周广红王维龙王博冯慧董丽丽贾文娟
Owner HARBIN ZHENBAO PHARMA
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