Nanopolymer Capsules Embedded with Oxygen Sensitive Fluorescent Indicator and Its Preparation and Application

A fluorescent indicator and nano-polymer technology, which is applied in the direction of fluorescence/phosphorescence, luminescent materials, and material analysis through optical means, and can solve the problems of indicator leakage, difficulty in accurately controlling the pore structure of the membrane matrix, and easy leakage of the indicator. , to achieve the effect of solving the leakage

Active Publication Date: 2018-11-06
杭州浸格科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the problems that the pore structure of the membrane matrix is ​​difficult to be precisely controlled and the indicator is easy to leak in the oxygen-sensitive fluorescent membrane prepared by the existing sol-gel method, the high-performance oxygen-sensitive fluorescent membrane prepared by the present invention can be used without affecting the optical properties of the indicator. At the same time, the leakage problem of the indicator is solved

Method used

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  • Nanopolymer Capsules Embedded with Oxygen Sensitive Fluorescent Indicator and Its Preparation and Application
  • Nanopolymer Capsules Embedded with Oxygen Sensitive Fluorescent Indicator and Its Preparation and Application
  • Nanopolymer Capsules Embedded with Oxygen Sensitive Fluorescent Indicator and Its Preparation and Application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) Prepare fluorine-free nanopolymer capsules embedded with an oxygen-sensitive fluorescent indicator with a core-shell ratio of 1:1, with an average particle size of 218.6nm. The specific steps are as follows:

[0053] 0.30 gram of amphiphilic macromolecular RAFT reagent and 49.70 gram of deionized water are prepared into an aqueous solution as the water phase, and 3.55 gram of methyl methacrylate, 1.42 gram of p-divinylbenzene, 0.07 gram of azobisisobutyl Nitrile, 4.94 g of paraffin and 0.02 g of tris(4,7-biphenyl-1,10-phenanthroline) ruthenium dichloride oil phase were mixed uniformly and ultrasonically pulverized for 20 minutes to obtain a fine emulsion. The miniemulsion is subjected to RAFT active radical miniemulsion polymerization under the condition of 160° C., cooled after reacting for 5 hours, and fluorine-free nanometer polymer capsules embedded with oxygen-sensitive fluorescent indicators are prepared.

[0054] (2) preparing an oxygen-sensitive fluorescent ...

Embodiment 2

[0058] Preparation of fluorine-free nanopolymer capsules embedded with oxygen-sensitive fluorescent indicators with a core-shell ratio of 1:2, with an average particle size of 228.7nm, and preparation of fluorine-free nanopolymer capsules embedded with oxygen-sensitive fluorescent indicators The oxygen-sensitive fluorescent film with a capsule concentration of 20%, the specific steps are as follows:

[0059] (1) 0.3 gram of amphiphilic macromolecular RAFT reagent and 49.7 gram of deionized water are mixed into an aqueous solution as the water phase, and 4.72 gram of methyl methacrylate, 1.89 gram of p-divinylbenzene, 0.09 gram of azo Diisobutyronitrile, 3.29 grams of paraffin and 0.01 grams of tris (4,7-biphenyl-1,10-phenanthroline) ruthenium dichloride oil phase and mixed evenly, after ultrasonic pulverization for 20 minutes to obtain a fine emulsion . The miniemulsion was subjected to RAFT active radical miniemulsion polymerization reaction at 160°C, and cooled after 5 hour...

Embodiment 3

[0062] The method of this embodiment is the same as that of Example 2, except that the dosage of the amphiphilic macromolecular RAFT agent is 0.32, 0.34, 0.36, and 0.38 grams respectively, and the particle size of the polymer capsule is regulated, and the model is ZEN1600 through the Marr Wen laser particle size analyzer tested the particle size of nano-polymer particles prepared by different amounts of RAFT reagents, and the average particle sizes were 215nm, 163.7nm, 152.9nm, and 146.0nm;

[0063] According to the method of Example 1, the oxygen-sensitive fluorescent films containing the nano-polymer capsules prepared in this example at a concentration of 20% were respectively prepared.

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Abstract

The invention provides nano-polymer capsules embedded with an oxygen-sensitive fluorescent indicator and a preparation method thereof, and application thereof to preparation of an oxygen-sensitive fluorescent film. The oxygen-sensitive fluorescent indicator is embedded into the nano-polymer capsules by adopting an RAFT (Reversible Additive Fragment Transfer) fine emulsion polymerization method; a core-shell structure and a surface shape of the nano-polymer capsules embedded with the oxygen-sensitive fluorescent indicator can be accurately regulated and controlled, so that effective embedding of the oxygen-sensitive fluorescent indicator is realized and the problem that the oxygen-sensitive fluorescent indicator is easy to leak is solved; a foundation of accurately and rapidly realizing online detection of DO (Dissolved Oxygen) in real time by a dissolved oxygen sensor is obtained; and fluorinated / fluorine-free nano-polymer capsules are combined with a sol-gel technology, so that the nano-polymer capsules embedded with the oxygen-sensitive fluorescent indicator can be uniformly dispersed into a sol-gel matrix to prepare a high-performance sol-gel oxygen-sensitive fluorescent film.

Description

(1) Technical field [0001] The invention relates to a nanometer polymer capsule embedded with an oxygen-sensitive fluorescent indicator, a preparation method thereof, and an application in preparing an oxygen-sensitive fluorescent film. (2) Background technology [0002] Dissolved Oxygen (Dissolved Oxygen) refers to the molecular oxygen dissolved in water by the exchange between water body and the atmosphere or chemical reaction, biochemical reaction, usually recorded as DO. The detection of dissolved oxygen concentration is of great significance in the fields of environmental monitoring, industrial production, clinical medicine and aquaculture. [0003] Optical fiber dissolved oxygen sensor is an important method to measure dissolved oxygen concentration. due to O 2 It is a natural quencher for some oxygen-sensitive fluorescent substances, and its quenching process is reversible, so most optical fiber dissolved oxygen sensors are based on the principle of oxygen-sensitive...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F265/02C08F220/14C08F212/36C08F2/38C08J5/18G01N21/64C09K11/02C09K11/06
CPCC08F2/38C08F265/02C08J5/18C08J2351/00C09K11/025C09K11/06C09K2211/185G01N21/643G01N2021/6432G01N2021/6439C08F220/14C08F212/36
Inventor 孙志娟蒋春跃郭飞
Owner 杭州浸格科技有限公司
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