Method for producing micro-needle array templates based on laser etching technology as well as products and application thereof

A microneedle array and laser etching technology, which is applied in laser welding equipment, surgery, manufacturing tools, etc., can solve the difficulties in mass production and application of microneedle array templates, complicated preparation process of microneedle array templates, poor structural design, etc. problem, to improve the effect of transdermal treatment, improve skin permeability, and easy to cure and form.
CN106511257AInactive Publication Date: 2017-03-22HUAZHONG UNIV OF SCI & TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUAZHONG UNIV OF SCI & TECH
Publication Date
2017-03-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for producing micro-needle array templates based on a laser etching technology as well as products and application thereof. The method comprises the following steps: (1) curing and cooling PDMS and a curing agent to obtain a PDMS substrate; (2) designing a laser etching mask plate pattern and enabling the pattern to be a concentric circle array; and (3) placing the PDMS substrate in an engraving area of a laser engraving machine and setting condition parameters of laser processing technology, subsequently carrying out laser treatment on the PDMS substrate with reference to the laser etching mask plate pattern so as to obtain the PDMS substrate etched by laser, wherein the PDMS substrate is the micro-needle array template. According to the method, the key laser etching process conditions are improved, so that the problems that the micro-needle array templates are complex in production process, high in cost and poor in structural design, and large-scale production and application of the micro-needle array templates are difficult can be effectively solved.
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Description

technical field

[0001] The invention belongs to the field of biomedical polymer materials, and more specifically relates to a preparation method for preparing a microneedle array template based on laser etching technology, a product thereof, and an application of the product in the preparation of soluble polymer microneedles. Background technique

[0002] Microneedles are three-dimensional arrays made of silicon, metal, and polymers with a length of 25-2000 μm and tapered needle tips. Microneedle is a new type of minimally invasive drug delivery tool in the field of biomedicine, which can enhance the effect of skin drug delivery through the epidermis and dermis of the skin. Microneedles have been widely used in the field of transdermal drug delivery due to their advantages of high efficiency, safety, and painlessness.

[0003] Soluble microneedles are microneedle arrays prepared by coating drugs in soluble or degradable polymer materials. The preparation method of soluble ...

Claims

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