Method for producing micro-needle array templates based on laser etching technology as well as products and application thereof

A microneedle array and laser etching technology, which is applied in laser welding equipment, surgery, manufacturing tools, etc., can solve the difficulties in mass production and application of microneedle array templates, complicated preparation process of microneedle array templates, poor structural design, etc. problem, to improve the effect of transdermal treatment, improve skin permeability, and easy to cure and form.

Inactive Publication Date: 2017-03-22
HUAZHONG UNIV OF SCI & TECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] For the above defects or improvement needs of the prior art, the object of the present invention is to provide a method and product and application for preparing a microneedle array template based on laser etching technology, wherein the key laser etching process conditions (including masking) Template setting, laser processing processing times, laser current, etc.) are improved, compared with the existi

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  • Method for producing micro-needle array templates based on laser etching technology as well as products and application thereof
  • Method for producing micro-needle array templates based on laser etching technology as well as products and application thereof
  • Method for producing micro-needle array templates based on laser etching technology as well as products and application thereof

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Example Embodiment

[0038] The method for preparing the microneedle array template provided by the laser etching technology generally includes the following steps:

[0039] (1) Preparation of PDMS substrate: Put PDMS and its curing agent (such as SYLGARD 184) in a plastic petri dish at a mass ratio of 20:1 to 5:1, and stir and mix thoroughly. The mass ratio can be preferably 10:1. Vacuum at 0.08MPa to remove bubbles in the mixture, heat and solidify at 70-90°C for 1 to 4 hours (also preferably heat and solidify at 80°C for 2 hours), and peel off after cooling;

[0040] (2) The design of the laser etching mask: use the engraving machine drawing software to draw a 10×10 concentric array with a diameter of 50 to 500 μm and a pitch of 200 to 600 μm; the diameter can be preferably 50 to 300 μm, more preferably 50 to 250μm, the pitch can be preferably 300~500μm;

[0041] (3) Etching of microneedle template: Place the PDMS substrate obtained in step (1) horizontally on PL-40 CO 2 In the engraving area of ​​th...

Example Embodiment

[0044] Example 1

[0045] The microneedle array template prepared based on laser etching technology in this embodiment is prepared according to the following method:

[0046] (1) Preparation of PDMS substrate: Put PDMS and its curing agent (such as SYLGARD 184) in a plastic petri dish at a mass ratio of 10:1, fully stir and mix, and vacuum at -0.08MPa to remove bubbles in the mixture. Heat and solidify at ℃ for 2h, then peel off after cooling to obtain the PDMS substrate required for laser etching;

[0047] (2) The design of the laser etching mask: use the drawing software of the engraving machine to draw a 10×10 concentric circle array with a diameter of 150μm and a spacing of 500μm; take any concentric circle in the concentric circle array as an example, the diameter here refers to The diameter corresponding to the circle with the largest diameter, and the diameter of the circle with the smallest diameter among the concentric circles may be 50 μm.

[0048] (3) Etching of microneedl...

Example Embodiment

[0050] Example 2

[0051] The microneedle array template prepared based on laser etching technology in this embodiment is prepared according to the following method:

[0052] (1) Preparation of PDMS substrate: Place PDMS and its curing agent in a plastic petri dish at a mass ratio of 10:1, fully stir and mix, vacuum at -0.08MPa to remove bubbles in the mixture, heat and cure at 80°C for 2h, After cooling, peel off to obtain the PDMS substrate required for laser etching;

[0053] (2) Laser etching mask design: draw a 10×10 concentric circle array with a diameter of 150μm and a spacing of 500μm with the drawing software of the engraving machine;

[0054] (3) Etching of microneedle array template: Place the PDMS substrate obtained in (1) horizontally on PL-40 CO 2 In the engraving area of ​​the laser engraving machine, import the mask pattern obtained in (2) into the laser etching software, set the laser current to 6mA, the laser scanning rate to 10cm / s and the laser processing times to ...

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Abstract

The invention discloses a method for producing micro-needle array templates based on a laser etching technology as well as products and application thereof. The method comprises the following steps: (1) curing and cooling PDMS and a curing agent to obtain a PDMS substrate; (2) designing a laser etching mask plate pattern and enabling the pattern to be a concentric circle array; and (3) placing the PDMS substrate in an engraving area of a laser engraving machine and setting condition parameters of laser processing technology, subsequently carrying out laser treatment on the PDMS substrate with reference to the laser etching mask plate pattern so as to obtain the PDMS substrate etched by laser, wherein the PDMS substrate is the micro-needle array template. According to the method, the key laser etching process conditions are improved, so that the problems that the micro-needle array templates are complex in production process, high in cost and poor in structural design, and large-scale production and application of the micro-needle array templates are difficult can be effectively solved.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and more specifically relates to a preparation method for preparing a microneedle array template based on laser etching technology, a product thereof, and an application of the product in the preparation of soluble polymer microneedles. Background technique [0002] Microneedles are three-dimensional arrays made of silicon, metal, and polymers with a length of 25-2000 μm and tapered needle tips. Microneedle is a new type of minimally invasive drug delivery tool in the field of biomedicine, which can enhance the effect of skin drug delivery through the epidermis and dermis of the skin. Microneedles have been widely used in the field of transdermal drug delivery due to their advantages of high efficiency, safety, and painlessness. [0003] Soluble microneedles are microneedle arrays prepared by coating drugs in soluble or degradable polymer materials. The preparation method of soluble ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/34A61K47/36A61L31/06A61L31/04A61L31/14B23K26/362
CPCA61K9/0021A61K47/34A61K47/36A61L31/042A61L31/06A61L31/14B23K26/361C08L83/04C08L5/08
Inventor 朱锦涛李朝柳佩陶娟董励芸
Owner HUAZHONG UNIV OF SCI & TECH
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