Dimetridazole encapsulated preparation and preparation method thereof

A nitazole package and preparation technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, microcapsules, etc., can solve the problems of low bioavailability, strong irritation, weak stability, etc., and achieves improved feed intake, good palatability, Stable effect

Inactive Publication Date: 2017-03-22
HUAIYIN TEACHERS COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By using the double encapsulation technology, the present invention can solve the disadvantages of poor palatability, strong irritation, weak stability and low bioavailability existing in the clinical use of existing dimenidazole medicaments.

Method used

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  • Dimetridazole encapsulated preparation and preparation method thereof
  • Dimetridazole encapsulated preparation and preparation method thereof
  • Dimetridazole encapsulated preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Add the original powder of Dimenidazole into stearic acid oil containing 3% by mass of calcium stearate and 1% of propylene glycol fatty acid ester in a mass ratio of 1:1, emulsify and shear at high speed for 40 minutes, The temperature is controlled at 70-80°C; the obtained material is transferred to 4 times the volume of an aqueous solution containing 1% chitosan, 0.5% sodium alginate and 1% sucrose ester, and the temperature is controlled at 70-80°C. Stir at a low speed of 200rpm for 30 minutes and then start to cool down until the encapsulated preparation of demenidazole in the solution is completely precipitated; stop stirring, filter and dehydrate the above materials through a 100-mesh sieve, and dry them in vacuum at low temperature to make encapsulated demenidazole preparation. The particle diameter range of this preparation is in 150 μ m-300 μ m, and the rate of recovery (the ratio of the weight of Dimenidazole encapsulated preparation and the total weight of f...

Embodiment 2

[0017] Add the original powder of dimenidazole into the stearic acid oil containing 5% calcium stearate and 0.8% propylene glycol fatty acid ester in a mass ratio of 1:10, high-speed emulsifying and shearing stirring for 20 minutes, The temperature is controlled at 70-80°C; the obtained material is transferred to 5 times the volume of an aqueous solution containing 1% chitosan, 0.5% sodium alginate and 1% sucrose ester, and the temperature is controlled at 70-80°C. Stir at a low speed of 200rpm for 30 minutes and then start to cool down until the encapsulated preparation of demenidazole in the solution is completely precipitated; stop stirring, filter and dehydrate the above materials through a 100-mesh sieve, and dry them in vacuum at low temperature to make encapsulated demenidazole preparation. The particle size range of the encapsulated preparation is 200 μm-500 μm, the recovery rate is 95.3%, the encapsulation rate is 97.6%, and the drug loading is 8.7%.

Embodiment 3

[0019] Add the original powder of Dimenidazole into the stearic acid oil containing 2% calcium stearate and 1.5% propylene glycol fatty acid ester in a mass ratio of 2:1, high-speed emulsifying and shearing stirring for 60 minutes, The temperature is controlled at 70-80°C; the obtained material is transferred to 4 times the volume of an aqueous solution containing 2% chitosan, 1% sodium alginate and 1.5% sucrose ester, and the temperature is controlled at 70-80°C. Stir at a low speed of 200rpm for 30 minutes and then start to cool down until the encapsulated preparation of demenidazole in the solution is completely precipitated; stop stirring, filter and dehydrate the above materials through a 100-mesh sieve, and dry them in vacuum at low temperature to make encapsulated demenidazole preparation. The particle size range of the encapsulated preparation is 100 μm-200 μm, the recovery rate is 97.9%, the encapsulation rate is 95.2%, and the drug loading is 60.6%.

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Abstract

The invention discloses a dimetridazole encapsulated preparation and a preparation method thereof. The preparation method comprises the steps of firstly adding dimetridazole raw powder into a stearic acid oil agent dissolved with calcium stearate and propylene glycol fatty acidate, adequately and uniformly stirring to obtain a mixture, adding the mixture into a water solution dissolved with chitosan, sodium alginate and sucrose ester, adequately and uniformly stirring, cooling, sieving, and drying, so as to obtain the dimetridazole microcapsule preparation. The preparation method is simple and scientific, the encapsulation rate and recovery rate of raw material drugs are relatively high, and the particle size of the medicament can be controlled. Clinical tests show that the dimetridazole encapsulated preparation is capable of obviously improving the palatability of livestock and has relatively good slow release performance; the efficient dimetridazole encapsulated preparation is provided for the livestock breeding industry.

Description

technical field [0001] The invention belongs to the technical field of veterinary chemical drug preparations, and in particular relates to a method for preparing an encapsulated preparation of dimetridazole. Background technique [0002] Dimetridazole (DMZ) is a nitroimidazole drug, mainly used for avian vibrio hepatitis, turkey histomoniasis, avian trichomoniasis and so on. At the same time, it can also be used as a growth promoter to promote the production of broilers and improve the feed conversion rate. Therefore, the drug is widely used in poultry production. [0003] Although Dimenidazole has played an extremely important role in poultry production, there are still some shortcomings: (1) Dimenidazole has a bitter taste, which will affect palatability after oral administration, resulting in reduced feed intake. Especially in the treatment of diseases, due to the decrease of feed intake, the dose of drug intake is insufficient, which affects the clinical efficacy; (2) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/4164A61K47/36A61K47/12A61P33/02A61P31/04
CPCA61K9/5036A61K9/5015A61K31/4164
Inventor 宦海霞龚建森盛中伟张萍何健张科周玉珍张迹
Owner HUAIYIN TEACHERS COLLEGE
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