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Drug-loaded composite nanofiber membrane used for drug release, and making method thereof

A composite nanofiber, drug-carrying technology, applied in pharmaceutical formulations, drug delivery, non-woven fabrics, etc., can solve the problems of difficult to control drug toxicity, drug efficacy is not long enough, poor stability, etc., to achieve good drug sustained release effect, Good biocompatibility, guaranteed delay and controlled effects

Inactive Publication Date: 2017-03-22
CHENGDU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the process of drug release, it is difficult to delay and control the drug release of traditional drug dosage forms, and there will be problems such as insufficient drug effect, poor stability, and difficult to control drug toxicity.

Method used

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  • Drug-loaded composite nanofiber membrane used for drug release, and making method thereof
  • Drug-loaded composite nanofiber membrane used for drug release, and making method thereof
  • Drug-loaded composite nanofiber membrane used for drug release, and making method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 3g chitosan and 7g polyamide respectively, mix the two and dissolve in formic acid to obtain a mixed solution with a concentration of 10wt%; then weigh 1g berberine hydrochloride and add it to the mixed solution. Stir magnetically for 20 minutes and stand still for 2 hours to obtain a uniform and transparent spinning dope. Put the spinning stock solution into the syringe, connect the positive pole of the high-voltage power supply to the needle tip of the syringe, the size of the needle is 12#, and connect the negative pole to the aluminum foil. At room temperature, the electric field was controlled at 7kV, the receiving distance was 13cm, and the electrospinning was performed at a flow rate of 0.4mL / h to obtain the drug-loaded chitosan / polyamide composite nanofiber membrane.

[0024] Take phosphate buffer as simulated body fluid, test the absorbance value of berberine hydrochloride in buffer solution, the absorption wavelength is 263nm, take the sample concentrati...

Embodiment 2

[0029] Weigh 1g chitosan and 9g polyamide respectively, mix the two and dissolve in formic acid to obtain a mixed solution with a concentration of 8wt%; then weigh 0.5g berberine hydrochloride and add it to the mixed solution, at 120r / min Stir under magnetic force for 15 minutes, and obtain a uniform and transparent spinning dope after standing still for 1 hour. Put the spinning stock solution into the syringe, connect the positive pole of the high-voltage power supply to the needle tip of the syringe, the size of the needle is 12#, and connect the negative pole to the aluminum foil. At room temperature, the electric field was controlled at 6.5kV, the receiving distance was 11cm, and the electrospinning was performed at a flow rate of 0.2mL / h to obtain the drug-loaded chitosan / polyamide composite nanofiber membrane.

[0030] Take phosphate buffer as simulated body fluid, test the absorbance value of berberine hydrochloride in buffer solution, the absorption wavelength is 263nm...

Embodiment 3

[0033] Weigh 2g chitosan and 8g polyamide respectively, mix the two and dissolve in formic acid to obtain a mixed solution with a concentration of 9wt%; then weigh 3g berberine hydrochloride and add it to the mixed solution. Stir magnetically for 28 minutes and stand still for 2.5 hours to obtain a uniform and transparent spinning dope. Put the spinning stock solution into the syringe, connect the positive pole of the high-voltage power supply to the needle tip of the syringe, the size of the needle is 12#, and connect the negative pole to the aluminum foil. At room temperature, the electric field was controlled at 7.8kV, the receiving distance was 14cm, and the electrospinning was performed at a flow rate of 0.9mL / h to obtain the drug-loaded chitosan / polyamide composite nanofiber membrane.

[0034] Take phosphate buffer as simulated body fluid, test the absorbance value of berberine hydrochloride in buffer solution, the absorption wavelength is 263nm, take the sample concentr...

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Abstract

The invention discloses a drug-loaded composite nanofiber membrane used for drug release, and a making method thereof. The method comprises the following steps: mixing polyamide and chitosan, dissolving the obtained mixture in formic acid to obtain a mixed solution, adding a drug to the mixed solution, stirring the drug and the mixed solution to accelerate dissolution in order to obtain a uniform and transparent spinning stock solution, and carrying out an electrostatic spinning technology to obtain the drug-loaded chitosan / polyamide composite nanofiber membrane. The produced nano-fiber membrane adopts polyamide as a main body, chitosan is added to realize a good blending effect, and drug release is regulated through swelling and degradation of chitosan, so the characteristics of good mechanical performance and the chemical stability of the polyamide and the antibacterial and anti-inflammatory property, the degradability and the good biocompatibility of the chitosan are fully shown. The drug-loaded composite nanofiber membrane has a good drug release effect and a high drug accumulative release rate as a novel composite drug slow release carrier material, and can be used in the biomedical fields of wound restoration, oral ulcer treatment and drug controlled release.

Description

technical field [0001] The invention relates to the field of drug sustained-release nanomaterials and its preparation, in particular to a drug-loaded composite nanofiber membrane for drug sustained release and a preparation method thereof. Background technique [0002] In the process of drug release, it is difficult to delay and control the release of traditional drug dosage forms, and there will be problems such as insufficient drug effect, poor stability, and difficult to control drug toxicity. As an effective drug carrier, bioactive polymers are widely used in the field of medicine, and the drug-loading system of polymers can protect the active ingredients of drugs, improve the efficacy of drugs, increase bioavailability and help drug targets Orientation and other characteristics. [0003] As a special fiber preparation technology, electrospinning has been widely used. By adjusting the process parameters of electrospinning, nanofiber materials with large specific surface...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/34A61K31/4375D04H1/4382D04H1/728
CPCA61K9/0002A61K31/4375A61K47/34A61K47/36D04H1/4382D04H1/728
Inventor 李峻峰高阳侯毅赵瑞兰刘恒全张佩聪赖雪飞
Owner CHENGDU UNIVERSITY OF TECHNOLOGY
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