Electrochemical synthesis method of 1,1'-diindolylmethane derivatives

Abstract

The invention discloses an electrochemical synthesis method of 1,1'-diindolylmethane derivatives. According to the method, indole derivatives, tetrahydrofuran and tetrahydrofuran derivatives are used as raw materials for synthetizing the 1,1'-diindolylmethane derivatives under the electrochemical condition. The method specifically comprises the following steps that the indole derivatives are taken and added into a mixed solvent of the tetrahydrofuran or tetrahydrofuran derivatives with acetonitrile, and a catalytic amount of lanthanum chloride and electrolyte lithium perchlorate are added; a platinum electrode is inserted into reaction liquid, stirring is conducted at the room temperature, and a reaction is carried out through electrification until the complete reaction is conducted; and the reaction liquid is extracted, concentrated and separated, and the 1,1'-diindolylmethane derivatives is obtained. Electricity is used for catalysis, expensive metal catalyzers and other oxidizing agents are not needed, stoichiometric lewis acid, protonic acid and heating are not needed either, reaction can be carried out mildly at the room temperature, the selectivity is good, the yield is high, and the whole process is simple and feasible; and the method is environmentally friendly and conforms to the idea of green chemistry.

Description

technical field [0001] The invention belongs to the field of organic electrosynthesis chemistry, relates to a method for synthesizing 1,1'-diindolylmethane derivatives, and in particular relates to a method for synthesizing 1,1'-diindolylmethane derivatives by using N-substituted indole and derivatives, tetrahydrofuran and tetrahydrofuran derivatives as raw materials, Methods of 1'-diindolylmethane derivatives. Background technique [0002] Many biologically active natural products contain indole derivatives, especially 1,1'-diindolylmethanes isolated from some terrestrial and marine organisms in recent years have shown better biological activity, Such as coronary dilating properties, genotoxicity, antibacterial activity and anticancer activity. Therefore, it has aroused the interest of many organic chemists and conducted extensive research on synthetic methods. [0003] At present, the main synthetic method is the condensation of aldehydes or ketones with indole or indole...

AI Technical Summary

Problems solved by technology

From the point of view of reaction conditions, when Lewis acid catalysis or protonic acid catalysis is used, in most cases, equivalent or excess is required, and in some cases even heating or reflux is required; when metal catalysis is used, it is sometimes necessary to add excess oxidant to promote metal redox cycle, Or the metals used are noble metals, and the cost is relatively high; of course, there are also relatively simple conditions, but they have substrate specificity and have certain limitations.

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