Photosensitizer having dual photodynamic therapy effects and preparation method thereof

A technology of photodynamic therapy and photosensitizer, which is applied in the field of photosensitizer and its preparation, can solve the problems of excessive oxygen consumption, poor photostability, poor water solubility, etc., and achieve the effect of easy-to-obtain raw materials, mild synthesis conditions and good photostability

Active Publication Date: 2017-04-26
合肥欧申福德生物科技有限责任公司
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently used photosensitizers generally have disadvantages such as poor wate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Photosensitizer having dual photodynamic therapy effects and preparation method thereof
  • Photosensitizer having dual photodynamic therapy effects and preparation method thereof
  • Photosensitizer having dual photodynamic therapy effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0037] The preparation method of the photosensitizer with dual photodynamic therapy effect in the present embodiment is as follows:

[0038] 1. Into a 250mL round-bottomed flask, sequentially add 100mL of a mixed solution of ethylene glycol monomethyl ether and water (V / V=3:1), 0.71g of IrCl 3 ·3H 2 O (2.0 mmol) and 0.68 g (4.4 mmol) of phenylpyridine were heated to 120°C and refluxed for 24 h. After the reaction was completed, the reaction was cooled to room temperature, and a yellow solid was precipitated, which was filtered with suction. The filter residue was washed with 30 mL of water and 30 mL of ethanol. times, the yellow powder (BP) was obtained after vacuum drying 4 Ir 2 Cl 2 .

[0039] 2. Add 0.21g (0.2mmol) (BP) to the 150mL Shrek bottle in turn 4 Ir 2 Cl 2 , 0.17g (0.5mmol) ETP and 50mL of a mixed solution of dichloromethane and methanol (V / V=1:1), refluxed at 60°C for 24h under nitrogen protection, cooled to room temperature after the reaction, and added 0....

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a photosensitizer having dual photodynamic therapy effects and a preparation method thereof, wherein the photosensitizer having the dual photodynamic therapy effects has the structural formula described in the specification. With cheap and easy-to-obtain 2-phenylpyridine, iridium trichloride and ethyl benzoate terpyridine as raw materials, and through mild reaction conditions, a target product-iridium complex is simply and efficiently synthesized. Research results indicate that the iridium complex has two-photon excited fluorescence emission in a near infrared region and can be used as a photosensitizer for photodynamic therapy. Confocal development is used for tracking the photodynamic therapy process, the photosensitizer iridium complex can be obviously observed to migrate from cell nucleuses to mitochondria under illumination, and secondary damage of the cells is caused. Animal experiments also prove that the iridium complex has quite good inhibitory effects on tumor growth under a near infrared irradiation condition and has low toxicity to animal bodies in dark environments.

Description

technical field [0001] The invention relates to a photosensitizer and a preparation method thereof, in particular to a photosensitizer with dual photodynamic therapy effects and a preparation method thereof. Background technique [0002] In recent decades, photodynamic therapy has attracted more and more attention. So far, photodynamic therapy has been successfully applied in the treatment of many diseases, such as: lung cancer, bladder cancer, ophthalmic cancer and urinary system tumors. Photodynamic therapy is a new technology that uses photodynamic response to treat tumors. The basis of photodynamic therapy is the photodynamic effect, which is a photosensitization reaction accompanied by biological effects involving oxygen molecules. Under the condition of light, the photosensitizer absorbs photons and transitions from the ground state to the excited state, and the molecules in the excited state transfer energy to the triplet oxygen during the falling process, convertin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0057
Inventor 田肖和祝英忠张明珠吴杰颖田玉鹏周虹屏杨家祥李胜利
Owner 合肥欧申福德生物科技有限责任公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap