Method for rapidly detecting metformin hydrochloride

Abstract

The invention provides a method for rapidly detecting metformin hydrochloride. According to the method, a copper sulphate solution and a sodium hydroxide solution are mixed to form a light blue aqueous solution, a screen printing electrode is placed in the solution, then is activated, a metformin hydrochloride sample is added, a high positive potential is applied, oxidation of metformin hydrochloride is promoted to form an intermediate, the intermediate is detected through a square wave anodic stripping voltammetry by a portable electrochemistry work station, and quantitative determination of metformin hydrochloride is indirectly completed. Compared with the prior art, no expensive apparatus and reagent is required during a sensor construction process and a detection process, operation is simple, and sensitivity is high.

Description

technical field [0001] The invention relates to a rapid detection method of metformin hydrochloride, in particular to a rapid detection method of metformin hydrochloride based on a copper modifier, a screen printing electrode and a portable electrochemical workstation. Background technique [0002] Diabetes mellitus is a metabolic disease caused by defects in insulin secretion or insulin action, and its main clinical feature is hyperglycemia. Sustained high blood sugar and long-term metabolic disorders can cause damage to the tissues and organs of the human body, especially the eyes, kidneys, cardiovascular system and nervous system. In recent years, more and more diabetic patients choose Chinese patent medicines or dietary supplements to assist in the treatment of diabetes. In order to make huge profits, criminals often add chemical hypoglycemic drugs, such as metformin, glibenclamide or rosiglitazone, to Chinese patent medicines and health products. These chemical hypogl...

AI Technical Summary

Problems solved by technology

At present, there are two common detection methods for metformin hydrochloride: one is the common biguanide rapid screening kit on the market, which is simple and convenient to operate, but the sensitivity is low, and the detection limit is 80mg / L, which is difficult to meet the high sensitivity detection requirements; the second is instrumental methods such as capillary electrophoresis, high-performance liquid chromatography, and fluorescence analysis. Although these methods have high sensitivity, the equipment is expensive, the detection cycle is long, and professional operation is required