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Porous starch composite material, and preparation method and applications thereof

A porous starch and composite material technology, applied in the field of materials, can solve the problems of poor hemostatic effect, high preparation cost, difficult in vivo degradation, etc., achieve good biological activity and degradability, good biological activity, and promote blood coagulation effect

Inactive Publication Date: 2017-05-03
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the shortcomings of current hemostatic materials such as high preparation cost, poor biocompatibility, poor hemostatic effect, and difficulty in in vivo degradation, as well as the complicated preparation process of the current porous starch hemostatic material, poor hemostatic effect, and easy to cause inflammatory reactions. , providing a porous starch composite material and its preparation method and application

Method used

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  • Porous starch composite material, and preparation method and applications thereof
  • Porous starch composite material, and preparation method and applications thereof
  • Porous starch composite material, and preparation method and applications thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0051] A preparation method of a porous starch / mesoporous calcium-zinc silicate composite hemostatic material, specifically completed according to the following steps:

[0052] (1) Preparation of porous starch

[0053] Add 100g of cornstarch, 2g of α-amylase, and 3g of glucoamylase into 250ml of phosphate buffer (sodium monohydrogen phosphate-phosphate buffer), stir at a temperature of 50°C and a pH of 5.8 to carry out the enzymolysis reaction , after 6 hours, centrifuged and dried to obtain porous starch;

[0054] (2) Preparation of Mesoporous Calcium Zinc Silicate

[0055] In the mixture of 4.0g P123 and 30mL water, the temperature was controlled at 45°C, 120mL of 2mol / L hydrochloric acid was added and mixed evenly, then 15.8g of zinc nitrate hexahydrate and 10.71g of calcium nitrate tetrahydrate were added, and 9.12mL of TEOS was dissolved in 15 Add it dropwise into the solution at a rate of drop / min, stir for 12 hours until the solution becomes cloudy, and then continue ...

Embodiment 2

[0059] A preparation method of a porous starch / mesoporous calcium-zinc silicate composite hemostatic material, specifically completed according to the following steps:

[0060] (1) Preparation of porous starch

[0061] Add 100g of cornstarch, 2g of α-amylase, and 3g of glucoamylase into 250ml of phosphate buffer (sodium monohydrogen phosphate-phosphate buffer), stir at a temperature of 50°C and a pH of 5.8 to carry out the enzymolysis reaction After 9 hours, centrifuge and dry to obtain porous starch.

[0062] (2) Preparation of Mesoporous Calcium Zinc Silicate

[0063] In the mixture of 4.0g P123 and 30mL water, the temperature was controlled at 45°C, 120mL of 2mol / L hydrochloric acid was added and mixed evenly, then 17.6g of zinc nitrate hexahydrate and 11.76g of calcium nitrate tetrahydrate were added, and 9.12mL of TEOS was dissolved in 15 Add it dropwise into the solution at a rate of drop / min, stir for 12 hours until the solution becomes cloudy, and then continue to st...

Embodiment 3

[0067] A preparation method of a porous starch / mesoporous calcium-zinc silicate composite hemostatic material, specifically completed according to the following steps:

[0068] (1) Preparation of tapioca starch

[0069] Add 100g of tapioca starch, 2g of β-amylase, and 3g of debranching enzyme into 500ml of phosphate buffer (sodium monohydrogen phosphate-phosphate buffer), stir at a temperature of 50°C and a pH of 5.8 to carry out the enzymolysis reaction After 6 hours, centrifuge and dry to obtain porous starch.

[0070] (2) Preparation of Mesoporous Calcium Zinc Silicate

[0071] In the mixture of 4.0g P123 and 30mL water, control the temperature at 45°C, add 120mL of 2mol / L hydrochloric acid and mix well, then add 13.1g of zinc nitrate hexahydrate and 9.761g of calcium nitrate tetrahydrate, and dissolve 9.12mL of TEOS in 15 Add it dropwise into the solution at a rate of drop / min, stir for 12 hours until the solution becomes cloudy, and then continue to stir to obtain a sol...

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Abstract

The invention discloses a porous starch composite material, and a preparation method and applications thereof. The preparation method comprises following steps: porous starch is uniformly mixed with mesoporous zinc calcium silicate; dissolving in an ethanol solution is realized; ultrasonic dispersion is carried out; centrifugation is carried out; filtering is carried out; and an obtained precipitate is dried so as to obtain the porous starch composite material; wherein the mass ratio of porous starch to mesoporous zinc calcium silicate is controlled to be 1:(0.2-0.4). The porous starch composite material possesses rapid and excellent hemostatic effect, is capable of resisting bacteria continuously, is high in biocompatibility; degradation in vivo is realized continuously; the preparation method is simple; and application prospect is promising.

Description

technical field [0001] The invention relates to the field of materials, in particular to a porous starch composite material and its preparation method and application. Background technique [0002] Blood loss is a common occurrence in daily life, especially various acute hemorrhages can greatly increase the mortality rate of the wounded. Whether the trauma bleeding of the wounded can be quickly and effectively controlled at the scene of the injury or on the way to the hospital will have great significance for improving the survival rate of the wounded. [0003] The traditional methods of hemostasis mainly include suturing, pressing, and dressing, and the main hemostatic materials include hemostatic bandages or tourniquets. With the rapid development of science and technology, hemostatic materials represented by thrombin, fibrin glue, oxidized cellulose, chitosan, porous zeolite, etc. have also come out one after another. According to the different hemostatic mechanisms, the...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/02C01B33/20
CPCA61L24/0089A61L24/0015A61L24/0036A61L24/0042A61L2300/10A61L2300/232A61L2300/404A61L2300/418A61L2400/04C01B33/20C01P2004/04
Inventor 牛云飞申晓军蒋熙郭列平纪方丁徐铭吴祥苏佳灿何大为魏强王春玲张东华
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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