Porous starch composite material, and preparation method and applications thereof

A porous starch and composite material technology, applied in the field of materials, can solve the problems of poor hemostatic effect, high preparation cost, difficult in vivo degradation, etc., achieve good biological activity and degradability, good biological activity, and promote blood coagulation effect

Inactive Publication Date: 2017-05-03
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the shortcomings of current hemostatic materials such as high preparation cost, poor biocompatibility, poor hemostatic effect, and difficulty in in vivo degradation, as well as the

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Porous starch composite material, and preparation method and applications thereof
  • Porous starch composite material, and preparation method and applications thereof
  • Porous starch composite material, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0050] Example 1

[0051] A preparation method of porous starch / mesoporous calcium zinc silicate composite hemostatic material is specifically completed according to the following steps:

[0052] (1) Preparation of porous starch

[0053] Add 100g of corn starch, 2g of α-amylase, and 3g of saccharification enzyme to 250ml of phosphate buffer (sodium monohydrogen phosphate-phosphate buffer), and stir at 50℃ and pH 5.8 for enzymatic hydrolysis. , After 6 hours, centrifuge and dry to obtain porous starch;

[0054] (2) Preparation of mesoporous calcium zinc silicate

[0055] In the mixture of 4.0g P123 and 30mL water, control the temperature at 45℃, add 120mL of 2mol / L hydrochloric acid and mix well, then add 15.8g of zinc nitrate hexahydrate and 10.71g of calcium nitrate tetrahydrate, add 9.12mL of TEOS to 15 Add dropwise to the solution at a rate of drop / min, and stir for 12 hours until the solution appears white and turbid, then continue to stir to obtain a sol-gel white emulsion. The ...

Example Embodiment

[0058] Example 2

[0059] A preparation method of porous starch / mesoporous calcium zinc silicate composite hemostatic material is specifically completed according to the following steps:

[0060] (1) Preparation of porous starch

[0061] Add 100g of corn starch, 2g of α-amylase, and 3g of saccharification enzyme to 250ml of phosphate buffer (sodium monohydrogen phosphate-phosphate buffer), and stir at 50℃ and pH 5.8 for enzymatic hydrolysis. , 9 hours later, centrifuged and dried to obtain porous starch.

[0062] (2) Preparation of mesoporous calcium zinc silicate

[0063] In the mixture of 4.0g P123 and 30mL water, control the temperature at 45℃, add 120mL of 2mol / L hydrochloric acid and mix well, then add 17.6g of zinc nitrate hexahydrate and 11.76g of calcium nitrate tetrahydrate, and add 9.12mL of TEOS to 15 Add dropwise to the solution at a rate of drop / min, and stir for 12 hours until the solution appears white and turbid, then continue to stir to obtain a sol-gel white emulsion...

Example Embodiment

[0066] Example 3

[0067] A preparation method of porous starch / mesoporous calcium zinc silicate composite hemostatic material is specifically completed according to the following steps:

[0068] (1) Preparation of tapioca starch

[0069] Add 100g of tapioca starch, 2g of β-amylase, and 3g of debranching enzyme to 500ml of phosphate buffer (sodium monohydrogen phosphate-phosphate buffer), stir at 50℃ and pH 5.8 for enzymatic hydrolysis After 6 hours, centrifugal separation and drying to obtain porous starch.

[0070] (2) Preparation of mesoporous calcium zinc silicate

[0071] In the mixture of 4.0g P123 and 30mL water, control the temperature at 45℃, add 120mL of 2mol / L hydrochloric acid and mix well, then add 13.1g of zinc nitrate hexahydrate and 9.761g of calcium nitrate tetrahydrate, and add 9.12mL of TEOS to 15 Add dropwise to the solution at a rate of drop / min, and stir for 12 hours until the solution appears white and turbid, then continue to stir to obtain a sol-gel white emul...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a porous starch composite material, and a preparation method and applications thereof. The preparation method comprises following steps: porous starch is uniformly mixed with mesoporous zinc calcium silicate; dissolving in an ethanol solution is realized; ultrasonic dispersion is carried out; centrifugation is carried out; filtering is carried out; and an obtained precipitate is dried so as to obtain the porous starch composite material; wherein the mass ratio of porous starch to mesoporous zinc calcium silicate is controlled to be 1:(0.2-0.4). The porous starch composite material possesses rapid and excellent hemostatic effect, is capable of resisting bacteria continuously, is high in biocompatibility; degradation in vivo is realized continuously; the preparation method is simple; and application prospect is promising.

Description

technical field [0001] The invention relates to the field of materials, in particular to a porous starch composite material and its preparation method and application. Background technique [0002] Blood loss is a common occurrence in daily life, especially various acute hemorrhages can greatly increase the mortality rate of the wounded. Whether the trauma bleeding of the wounded can be quickly and effectively controlled at the scene of the injury or on the way to the hospital will have great significance for improving the survival rate of the wounded. [0003] The traditional methods of hemostasis mainly include suturing, pressing, and dressing, and the main hemostatic materials include hemostatic bandages or tourniquets. With the rapid development of science and technology, hemostatic materials represented by thrombin, fibrin glue, oxidized cellulose, chitosan, porous zeolite, etc. have also come out one after another. According to the different hemostatic mechanisms, the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L24/08A61L24/02C01B33/20
CPCA61L24/0089A61L24/0015A61L24/0036A61L24/0042A61L2300/10A61L2300/232A61L2300/404A61L2300/418A61L2400/04C01B33/20C01P2004/04
Inventor 牛云飞申晓军蒋熙郭列平纪方丁徐铭吴祥苏佳灿何大为魏强王春玲张东华
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap