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A kind of preparation method of high-efficiency antibacterial compound hemostatic sponge

A hemostatic sponge and high-efficiency technology, used in pharmaceutical formulations, surgical adhesives, bandages, etc., can solve the problems of single function of hemostatic materials and unsatisfactory hemostatic effect, and achieve the purpose of promoting wound healing, shortening hemostasis time, and improving water absorption and swelling. Effect

Active Publication Date: 2019-07-02
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for preparing a high-efficiency antibacterial composite hemostatic sponge in order to solve the problems of current hemostatic materials with single function, unsatisfactory hemostatic effect and risk of thrombosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Dissolve 2g of sodium alginate powder in 100ml of deionized water to obtain a 2% sodium alginate solution, add 0.005g of NaCl and 0.2g of quaternary phosphonium salt, stir well, and use it as liquid A; add 3% span80 and Prepare mixed emulsifier solution with 1% Tween80 as liquid B; prepare 5% calcium chloride solution as liquid C; use emulsification cross-linking method, add liquid A to liquid B according to the water-oil ratio of 1:5, rotate at 470rpm, 45 Stir in a constant temperature water bath at ℃ for 15 minutes to form an emulsion, then add liquid C to the emulsion drop by drop at a rate of 30 drops / min, react for 20 minutes after the addition is complete, add isopropanol to solidify for 10 minutes, centrifuge, Washing and drying, the porous alginate drug-loaded microspheres are obtained;

[0033] Dissolve 2g of chitosan hydrochloride (molecular weight: 100,000, degree of deacetylation: 85%) in deionized water to make a 2% (w / v) aqueous solution, add 0.1g of porou...

Embodiment 2

[0036] Dissolve 2g of sodium alginate powder in 100ml of deionized water to obtain a 2% sodium alginate solution, add 0.02g of NaCl and 1g of quaternary phosphonium salt, stir well, and use it as liquid A; add 3% span80 and Prepare mixed emulsifier solution with 1% Tween80 as liquid B; configure 5% calcium chloride solution as liquid C; use emulsification cross-linking method, add liquid A to liquid B according to the water-oil ratio of 1:10, rotate at 470rpm, 45 Stir in a constant temperature water bath at ℃ for 15 minutes to form an emulsion, then add liquid C to the emulsion drop by drop at a rate of 30 drops / min, react for 30 minutes after the addition is complete, add isopropanol to solidify for 10 minutes, centrifuge, Washing and drying, the porous alginate drug-loaded microspheres are obtained;

[0037] Dissolve 2g of chitosan hydrochloride (molecular weight: 100,000, degree of deacetylation: 90%) in deionized water to make a 2% (w / v) aqueous solution, add 0.4g of porou...

Embodiment 3

[0040] Dissolve 2g of sodium alginate powder in 100ml of deionized water to obtain a 2% sodium alginate solution, add 0.01g of NaCl and 0.5g of quaternary phosphonium salt, stir well, and use it as liquid A; add 3% span80 and Prepare mixed emulsifier solution with 1% Tween80 as liquid B; configure 5% calcium chloride solution as liquid C; use emulsification cross-linking method, add liquid A to liquid B according to the water-oil ratio of 1:8, rotate at 470rpm, 45 Stir in a constant temperature water bath at ℃ for 15 minutes to form an emulsion, then add liquid C to the emulsion drop by drop at a rate of 30 drops / min, react for 30 minutes after the addition is complete, add isopropanol to solidify for 10 minutes, centrifuge, Washing and drying, the porous alginate drug-loaded microspheres are obtained;

[0041] Dissolve 2g of chitosan hydrochloride (molecular weight: 100,000, degree of deacetylation: 88%) in deionized water to make a 2% (w / v) aqueous solution, add 0.3g of poro...

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PUM

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Abstract

The invention discloses a preparation method for efficient anti-bacterial composite hemostatic sponge. The preparation method comprises the following steps: S1, adding sodium chloride and phosphonium salt into a sodium alginate solution to obtain a solution A; S2, adding an emulsifier into dispersion liquid to obtain a solution B, and preparing a 4 to 6 percent calcium chloride solution to serve as a solution C; S3, adding the solution A into the solution B in a water-oil ratio of 1 to (3-7) by an emulsion-crosslinking method, stirring to form an emulsion, adding the solution C into the emulsion for reacting, curing, centrifuging, washing and drying to obtain porous alginate drug-carrying microspheres; S4, dissolving chitosan hydrochloride into water to obtain an aqueous solution, adding the porous alginate drug-carrying microspheres prepared in the step S2 and a hemostatic medicament, performing freeze drying repeatedly, washing and sterilizing to obtain the hemostatic sponge. The hemostatic sponge has high water absorptivity, can rapidly stop bleeding, plug wounds, inhibit wound infection and effectively promote healing of the wounds; the thrombus risk is avoided.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and more specifically relates to a preparation method of a high-efficiency antibacterial composite hemostatic sponge. Background technique [0002] Effective hemostasis is the key to relieving patients' suffering and reducing mortality, and rapid and effective hemostasis has become the focus of solving this problem. In daily life, it is inevitable to encounter damage to body tissues caused by various unexpected accidents and disasters. Hemostasis is the first step in wound treatment, and it also directly affects subsequent wound healing. At present, common hemostatic materials include microporous inorganic materials (zeolite), microporous starch, fibrin glue, gelatin sponge, carboxymethylcellulose soluble hemostatic gauze, α-cyanoacrylate tissue glue, etc. These materials Although there is a good hemostatic effect, each has certain limitations. Gelatin and distant tissues have poo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/08A61L15/46A61L15/42A61L15/28A61L15/40A61L15/44
CPCA61L15/28A61L15/40A61L15/425A61L15/44A61L15/46A61L24/0005A61L24/0015A61L24/0036A61L24/08A61L2300/232A61L2300/30A61L2300/404A61L2300/418A61L2400/04C08L5/04C08L5/08
Inventor 李思东王超敖宁建陈法锦胡章李普旺李程鹏廖铭能欧阳茜茜潘江球
Owner GUANGDONG OCEAN UNIVERSITY
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