Unlock instant, AI-driven research and patent intelligence for your innovation.

Carboxyethyl chitosan sponge dressing and preparation method thereof

A technology of carboxyethyl chitosan sponge and carboxyethyl chitosan, applied in medical science, bandages, absorbent pads, etc., can solve problems affecting wound healing, human tissue damage, user pain, etc. Large-scale popularization and application, large absorption and good biocompatibility

Active Publication Date: 2017-05-10
JIANGSU NEWVALUE MEDICAL PROD CO LTD +1
View PDF6 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, these methods have adopted toxic reagents such as formaldehyde, glyoxal, and glutaraldehyde as crosslinking agents in the process of preparing chitosan sponges. Even if trace amounts of these toxic crosslinking agents remain, they will still cause various degrees of damage to human tissues. damage, affecting the healing of the wound and causing unnecessary pain to the user

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Carboxyethyl chitosan sponge dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take by weighing carboxyethyl chitosan (prepared with reference to the following documents: Hitoshi Sashiwa, et al. acrylic acid in water.Macromol.Biosci.2003, 3, 231-233) 1g, put in 100ml water, stir and dissolve at room temperature, freeze at -80°C for 50 hours, then vacuum at -40°C, 5pa Dry for 12 hours to obtain a thickness of 0.1mm and a density of 0.016g / cm 3 carboxyethyl chitosan sponge. Place it in the reaction chamber of a plasma treatment instrument (plasma surface treatment instrument, GSL1100X-PJF, Hefei Kejing Material Technology Co., Ltd.) for glow discharge treatment, the working gas is nitrogen, the reaction chamber pressure is 20pa, and the processing power is 10w. The treatment time is 15s. After the treatment is completed, it is placed in an oven for 1 hour at a temperature of 50 degrees Celsius and a humidity of 20% to obtain a carboxyethyl chitosan sponge dressing 1 .

Embodiment 2

[0036]Take by weighing the carboxyethyl chitosan (prepared with reference to the following documents: Y.Wu, et al.Preparation of O-carboxymethyl chitosans and their effect on the viscosity-average molecular weight at 1000000Da, 6-position O-carboxyethyl molar substitution degree at 0.5) Color yield of acid dyes on silk.J.Appl.Polym.Sci.2003, 90, 2500-2502) 5g, put in 100ml water, stir and dissolve at room temperature, freeze at -20°C for 10 hours, and then put in - Vacuum drying at 40 degrees and 300pa for 24 hours to obtain a thickness of 5mm and a density of 0.025g / cm 3 carboxyethyl chitosan sponge. Place it in the reaction chamber of a plasma treatment instrument (plasma surface treatment instrument, GSL1100X-PJF, Hefei Kejing Material Technology Co., Ltd.) for glow discharge treatment, the working gas is nitrogen, the reaction chamber pressure is 50pa, and the processing power is 50w. The treatment time is 30s. After the treatment is completed, it is placed in an oven for...

Embodiment 3

[0038] Take by weighing viscosity average molecular weight at 2000000Da, 2-N-, the carboxyethyl chitosan of 6-O-molar degree of substitution at 0.8 (preparation with reference to following literature: Sun Shengling, Wang Aiqin. N, O-carboxyethyl chitosan Adsorption properties of the synthesis of metal ions, Polymer Materials Science and Engineering, 2006, 22(3), 25-29) 10g, placed in 100ml of water, stirred and dissolved at room temperature, placed in -40 ℃ low temperature for 24 hours, Then vacuum dry for 48 hours under the conditions of -40 degrees and 30pa to obtain a thickness of 10mm and a density of 0.032g / cm 3 carboxyethyl chitosan sponge. Put it in the reaction chamber of the plasma processing instrument (plasma surface treatment instrument, GSL1100X-PJF, Hefei Kejing Material Technology Co., Ltd.) for glow discharge treatment, the working gas is nitrogen, the pressure of the reaction chamber is 100pa, and the processing power is 100w , the treatment time is 60s, and ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Densityaaaaaaaaaa
Thicknessaaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of a carboxyethyl chitosan sponge dressing. The preparation method comprises the following steps: a, preparing carboxyethyl chitosan into carboxyethyl chitosan sponge; b, activating the carboxyethyl chitosan sponge by adopting plasma treatment, thus obtaining activated carboxyethyl chitosan sponge; c, treating the activated carboxyethyl chitosan sponge under the conditions that the temperature is 50 to 200 DEG C and the humidity is 20 to 70 percent, thus obtaining the carboxyethyl chitosan sponge dressing. The invention also provides the relevant carboxyethyl chitosan sponge dressing. During a preparation process of the carboxyethyl chitosan sponge dressing, no toxic reagent is used, no residue of the toxic reagent exists, the biocompatibility is good, different degrees of damage to human tissues cannot be caused, wound healing cannot be influenced, and unnecessary pain cannot be brought to a user; the preparation technology is simple, safety and environment protection are realized, liquid absorption is quick, the absorption amount is large, and the preparation method is suitable for being popularized and applied to a large scale.

Description

technical field [0001] The invention relates to the technical field of medical dressings, more specifically to the technical field of chitosan sponge dressings, in particular to a carboxyethyl chitosan sponge dressing and a preparation method thereof. Background technique [0002] Chitosan sponge dressing, as a degradable and absorbable porous dressing made of natural polymers, has the characteristics of soft texture and good compliance, especially the remarkable characteristics of absorbing a large amount of wound exudate and fast absorption rate , so that it is widely used in the field of clinical acute and chronic wound treatment. [0003] At present, the commonly used preparation method of chitosan sponge dressing is mainly chemical cross-linking method, that is, the amino group or hydroxyl group on the chitosan sponge dressing is reacted and cross-linked by a cross-linking agent, so that it no longer has water solubility, and achieves The purpose of absorbing liquid. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08J9/36C08J9/28C08L5/08A61L15/28A61L15/42
Inventor 周应山龚祖光蒋锐王立平
Owner JIANGSU NEWVALUE MEDICAL PROD CO LTD