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Biodegradable slow/controlled-release drug delivery system and preparation method thereof

A technology of biodegradation and drug delivery system, applied in the field of biodegradable sustained and controlled release drug delivery system and its preparation, which can solve the problems of reduced therapeutic effect, drug inactivation, and danger to the user's life, and achieve the elimination of "explosive release" effect , good dimensional stability and diverse shapes

Inactive Publication Date: 2017-05-17
LIAONING RES INST OF FAMILY PLANNING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantage is that the direct introduction of drugs can only be drugs that do not contain hydroxyl groups or drugs that do not contain groups that can participate in polymerization reactions. Reduced healing effect, even life-threatening to the user
The disadvantage is that irradiation cross-linking will also destroy the chemical structure of the drug molecule, leading to inactivation of the drug, resulting in reduced therapeutic effect, and even life-threatening to the user

Method used

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  • Biodegradable slow/controlled-release drug delivery system and preparation method thereof
  • Biodegradable slow/controlled-release drug delivery system and preparation method thereof
  • Biodegradable slow/controlled-release drug delivery system and preparation method thereof

Examples

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Embodiment 1

[0032] In this embodiment, the biodegradable sustained and controlled release drug delivery system and its preparation method are as follows:

[0033] Accurately weigh 100mg gestodene and dissolve it in 50ml chloroform to prepare a drug solution with a concentration of 2mg / ml; place a polytrimethylene carbonate three-dimensional network polymer rod (150mg in weight) with a length of 20mm and a diameter of 3mm In the drug solution, take it out after 7 days, leave it naturally for 1 day, and vacuum-dry it to constant weight to obtain a biodegradable sustained and controlled release drug delivery system with a drug loading capacity of 20 mg gestodene.

[0034] Such as Figure 1(a)-Figure 1(b) As shown, the biodegradable sustained and controlled release drug delivery system prepared by the polytrimethylene carbonate three-dimensional network polymer of the present invention as a drug carrier has the following characteristics: after cleaning, there is no drug enrichment and precipit...

Embodiment 2

[0036] In this embodiment, the biodegradable sustained and controlled release drug delivery system and its preparation method are as follows:

[0037] Accurately weigh 100mg gestodene and dissolve it in 50ml chloroform to prepare a drug solution with a concentration of 2mg / ml; place a polytrimethylene carbonate three-dimensional network polymer rod (the weight of which is 225mg) with a length of 30mm and a diameter of 3mm In the drug solution, take it out after 7 days, leave it naturally for 1 day, and vacuum-dry it to constant weight to obtain a biodegradable sustained and controlled release drug delivery system with a drug loading capacity of 30 mg gestodene.

Embodiment 3

[0039] In this embodiment, the biodegradable sustained and controlled release drug delivery system and its preparation method are as follows:

[0040] Accurately weigh 100mg gestodene and dissolve it in 50ml chloroform to prepare a drug solution with a concentration of 2mg / ml; place a polytrimethylene carbonate three-dimensional network polymer rod (150mg in weight) with a length of 20mm and a diameter of 3mm In the drug solution, take it out after 7 days, leave it naturally for 1 day, vacuum dry to constant weight, spray polytrimethylene carbonate with a thickness of 0.5mm on the surface, and dry to constant weight to obtain a biological drug with a drug loading of 20mg Gestodene Degradable sustained and controlled release drug delivery system.

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Abstract

The invention relates to the fields of chemical and medical biological materials and biomedicine, and particularly relates to a biodegradable slow / controlled-release drug delivery system and a preparation method thereof. The system using one or more than two biodegradable three-dimensional network polymers or biodegradable crosslinked elastomers as a drug carrier, and the drug content in the system by weight is more than 0-50%.By using the biodegradable three-dimensional network polymers as the drug carrier, the drug is loaded on the drug carrier through a swelling method. The process provided by the invention is simple and easy to operate; and the drug loading capacity of the drug delivery system can be changed by changing the concentration of a drug solution, the physical behavior of a drug carrier product, dimension parameters and the other parameters. The system has higher application prospects in the fields of tissue engineering and drug slow release, and can be used for disease prevention and treatment and other aspects through surgical sutures, anti-adhesive membranes, tissue engineering scaffolds, subcutaneous implants, contraceptive implants and transdermal or inhalation drug delivery.

Description

technical field [0001] The invention relates to the fields of chemistry, medical biological materials and biomedicine, in particular to a biodegradable sustained and controlled release drug delivery system and a preparation method thereof. Background technique [0002] Controlled drug release is beneficial to improve the efficacy of drugs, reduce side effects, and reduce the pain of repeated drug use for patients. For a long time, drug carriers based on polymer materials have been the most active research system in the field of controlled drug release. The release system using polymers as drug carriers first appeared in the 1980s. Segal et al. used silicone rubber as a carrier material to pack progesterone in silicone rubber microcapsules for family planning research. The results of the study showed that the drug was released slowly over a long period of time, and the therapeutic effect was satisfactory. But the problem is that it is found that organosilicon materials can ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K45/00A61K47/34A61K31/567A61K31/192A61L17/10A61L27/18A61L27/54A61L27/58A61L31/06A61L31/14A61L31/16
CPCA61K9/0002A61K9/0014A61K9/0024A61K9/007A61K31/192A61K31/567A61K45/00A61K47/34A61L17/005A61L17/105A61L27/18A61L27/54A61L27/58A61L31/06A61L31/148A61L31/16A61L2300/216A61L2300/222C08L69/00
Inventor 杨立群
Owner LIAONING RES INST OF FAMILY PLANNING
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