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A multi-coated biodegradable metal stent and its preparation method

A metal stent and multi-coating technology, which is applied in the field of medical devices, can solve the problems of uncontrollable service life and curative effect of stents, uncontrollable degradation time, and complicated manufacturing process of magnesium stents, and achieves long service life, strong supporting force, and prevention of restenosis effect

Active Publication Date: 2019-12-24
万瑞飞鸿(北京)医疗器材有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] It can be seen that due to the need for additional corrosion-resistant treatment, the manufacturing process of magnesium stents is more complicated, and the degradation time is uncontrollable, resulting in uncontrollable service life and curative effect of the stent

Method used

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  • A multi-coated biodegradable metal stent and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Such as figure 1 As shown, it is a multi-coated biodegradable metal stent of the present invention,

[0054] It includes: a stent body 1, a drug coating 2, a first temperature control coating 3 and a second temperature control coating 4; the inner surface of the stent body 1 is provided with a first temperature control coating 3, and the outer surface is provided with a second temperature control coating. Temperature coating 4; The drug coating 2 is arranged on the outer surface of the second temperature control coating 4;

[0055] The bracket body 1 is made of pure magnesium;

[0056] The first temperature-controlling coating 3 and the second temperature-controlling coating 4 are degradable polymer layers with blood-cooling, antipyretic and temperature-controlling molecules;

[0057] The drug coating 2 is a composite degradable drug coating with drugs for inhibiting intimal hyperplasia, PDLLA and PLLA.

[0058] Preparation Process:

[0059] The high-purity magnesiu...

Embodiment 2

[0071] Such as figure 1 As shown, it is a multi-coated biodegradable metal stent of the present invention,

[0072] It includes: a stent body 1, a drug coating 2, a first temperature control coating 3 and a second temperature control coating 4; the inner surface of the stent body 1 is provided with a first temperature control coating 3, and the outer surface is provided with a second temperature control coating. Temperature coating 4; The drug coating 2 is arranged on the outer surface of the second temperature control coating 4;

[0073] The bracket body 1 is made of magnesium alloy;

[0074] The first temperature-controlling coating 3 and the second temperature-controlling coating 4 are degradable polymer layers with blood-cooling, antipyretic and temperature-controlling molecules;

[0075] The drug coating 2 is a composite degradable drug coating with drugs for inhibiting intimal hyperplasia, PDLLA and PLLA.

[0076] Preparation Process:

[0077] The magnesium alloy tub...

Embodiment 3

[0090] With embodiment 1, difference is:

[0091] The thickness of the stent body is 90 μm;

[0092] The thickness of the first temperature control coating is 10 μm;

[0093] The thickness of the second temperature control coating is 2 μm;

[0094] The thickness of the drug coating is 5 μm;

[0095] The degradable polymer with blood-cooling, antipyretic and temperature-controlling molecules is a mixed solution of acetaminophen, polyglycolic acid, polylactic acid and polyglycolic acid copolymer (the mixing ratio is 0.5:0.5:1:1).

[0096] The results of the stent test were similar to Example 1.

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Abstract

The invention discloses a multi-coating bio-degradable metal support. The multi-coating bio-degradable metal support comprises a support body, a medicine coating, a first temperature-control coating and a second temperature-control coating; an inner surface of the support body is provided with the first temperature-control coating, and an outer surface is provided with a second temperature-control coating; and the medicine coating is arranged at the outer surface of the second temperature-control coating. The invention also discloses a preparation method of the metal support. The multi-coating bio-degradable metal support is long in service life, good in curative effect, high in supporting force, and good in biological safety.

Description

technical field [0001] The invention relates to the field of medical instruments. More specifically, it relates to a multi-coated biodegradable metal stent and a preparation method thereof. Background technique [0002] At present, the main method for treating cardiac artery stenosis is long-term implantation of metal stents. However, the implantation of metal stents still has some disadvantages, such as thrombus formation leading to restenosis of blood vessels at the implantation site, long-term local inflammatory response, stimulation of surrounding tissues, mechanical behavior of stent implantation and no stent Mismatch, etc., making it problematic for long-term use. Therefore, it is urgent to develop a human degradable and absorbable stent as a coronary stent. [0003] For the more mature biodegradable polymer scaffolds, because their mechanical properties cannot meet the requirements, in order to improve the strength of the scaffolds, the volume must be increased, wh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/54A61L27/34A61L27/18A61L27/04A61F2/82
Inventor 唐文军王海军
Owner 万瑞飞鸿(北京)医疗器材有限公司
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