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Sterilizing and disinfecting solid-state medical ultrasonic coupling patch and preparation method thereof

An ultrasonic coupling, disinfection and sterilization technology, applied in the field of biomedicine, can solve the problems of allergic reactions of skin and mucous membranes, affecting the quality of ultrasonic images, incompatibility, etc., and achieves good biocompatibility, reliable disinfection and sterilization effect, convenient and sanitary use. Effect

Active Publication Date: 2017-05-24
广东速康特医食品科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polyhexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, etc. belong to cationic surfactants. Antimicrobials can damage transducers or affect the quality of ultrasound images
At the same time, chemically speaking, there are a large number of carboxyl groups in the carbomer molecule, which is an anionic polymer and cannot be sterilized with cationic bacteria such as polyhexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, and chlorhexidine acetate. Agent compatibility
Methyl and propyl parabens antimicrobial preservatives are effective against molds and yeasts, but often cause allergic reactions on the skin and mucous membranes

Method used

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  • Sterilizing and disinfecting solid-state medical ultrasonic coupling patch and preparation method thereof
  • Sterilizing and disinfecting solid-state medical ultrasonic coupling patch and preparation method thereof
  • Sterilizing and disinfecting solid-state medical ultrasonic coupling patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 iota-carrageenan

[0043] 1) Take Eucheuma spinach, remove impurities, wash and dry, then soak in 13% potassium hydroxide alkali solution, subject to complete immersion of the algae body, soak for 6 hours at a temperature of 30°C, filter out the alkali solution, wash the algae with deionized water until neutral;

[0044] 2) Cut the algal body into pieces, add deionized water with an amount 28 times its mass and tea saponin with a mass 3‰, mix well, and perform ultrasonic extraction at a temperature of 90°C for 2 hours, filter to remove the filter residue, and then use silicon The diatomaceous earth and activated carbon compound is used as a filter aid, and it is filtered twice while it is hot; according to the mass ratio, diatomaceous earth: activated carbon is 1:2;

[0045] 3) After the filtrate is cooled to 50-60°C, concentrate under reduced pressure to 1 / 3 of the original volume, add calcium chloride and ethanol with a volume fraction...

Embodiment 2

[0046] The preparation of embodiment 2 modified bletilla striata polysaccharides

[0047] (1) Get bletilla striata tubers, remove impurities, wash and dry, pulverize, pass through a 60-mesh sieve, add 4 times the mass of bletilla striata powder and soak in ethanol with a volume fraction of 90% for 4 hours, filter off ethanol, and wash bletilla striata powder with deionized water 2 Add deionized water with 12 times the mass of bletilla striata powder and compound protease with 8‰ mass of bletilla striata powder, extract at a temperature of 60°C and a pH of 6.5 for 3 hours, filter to remove the filter residue, and then filter the filtrate with diatomaceous earth and activated carbon The compound is a filter aid, wherein, according to the mass ratio, diatomaceous earth: activated carbon is 1:0.7, filtered twice, after the last filtration, the filtrate is refrigerated and centrifuged at 8000r / min at 4°C for 10min, the supernatant is taken, and concentrated under reduced pressure to...

Embodiment 3

[0051] Example 3 Disinfection and sterilization solid-state medical ultrasonic coupling patch and its preparation

[0052] The disinfection and sterilization solid-state medical ultrasonic coupling patch of this embodiment consists of the following components in terms of mass percentage: 0.7% of iota-carrageenan prepared in Example 1, 1.2% of modified Bletilla striata polysaccharide prepared in Example 2, Carboxymethyl chitosan 1.8%, tea tree oil 2%, glyceryl monocaprylate 0.8%, glycerin 0.5%, and the balance is deionized water.

[0053] Preparation:

[0054] S1: Take tea tree oil, glyceryl monocaprylate and glycerin, stir and mix to obtain mixture I;

[0055] S2: Get ι-carrageenan, modified Bletilla striata polysaccharide and carboxymethyl chitosan, dissolve with deionized water, and make mixed solution II;

[0056] S3: Adjust the pH of the mixed solution II described in S2 to 6.8, stir for 5 minutes, add the mixture I described in S1, stir for 2 hours at a temperature of 2...

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Abstract

The invention belongs to the technical field of biological medicine, and relates to a sterilizing and disinfecting solid-state medical ultrasonic coupling patch and a preparation method thereof. The sterilizing and disinfecting solid-state medical ultrasonic coupling patch provided by the invention comprises the following components by the mass percentage: 0.5-1.5% of iota-carrageenan, 1.2-1.8% of modified bletilla striata polysaccharide, 1.6-2.5% of carboxymethyl chitosan, 0.5-2% of tea tree oil, 0.1-0.8% of glycerol monocaprylate, 0.1-0.5% of glycerol, and the balance deionized water. The sterilizing and disinfecting solid-state medical ultrasonic coupling patch provided by the invention has the advantages of good acoustic performance, good ultrasonic transmission effect, clear ultrasonic images, and high resolution ratio; at the same time, the sterilizing and disinfecting solid-state medical ultrasonic coupling patch does not adhere to skin or an ultrasonic probe after use, is convenient and healthful to use, does not damage the probe or affect ultrasonic wave transmission, and has the advantages of good biocompatibility, reliable sterilizing and disinfecting effects, and stable physical and chemical properties.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a sterilizing solid-state medical ultrasonic coupling patch and a preparation method thereof. Background technique [0002] When ultrasonic waves are incident on the interface between two different media, the greater the difference in impedance between the two, the greater the reflection coefficient, and the less sound energy that passes through the interface into another medium. Therefore, in ultrasonic diagnosis and treatment operations, it is necessary to fill the medical ultrasonic gel between the radiating surface of the ultrasonic probe and the skin. Medical ultrasonic coupling agent is an essential auxiliary preparation for ultrasonic diagnostic instrument probes. It is used to fill the intermediary medium for transmitting sound waves between the radiating surface of the ultrasonic probe and the skin. It is the propagation channel of ultrasonic waves. The q...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K31/722A61K31/715A61K47/36C08B37/00
CPCA61K31/715A61K31/722A61K47/36A61K49/22C08B37/0003A61K2300/00
Inventor 胡波宋雨润王英男王志吉万柏钢
Owner 广东速康特医食品科技有限公司
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