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Metronidazole-erythromycin compound ointment for treating face acnes and preparation method thereof

A technology for metronidazole erythromycin and facial acne, applied in the field of medicine, can solve problems such as affecting facial appearance, easy recurrence of erythromycin, pigmentation and the like, and achieve the effects of good effectiveness, good stability and improved effectiveness

Active Publication Date: 2017-05-31
翟学英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Erythromycin is a macrolide antibiotic with a broad antibacterial spectrum. It has a strong inhibitory effect on Gram-positive bacteria and a considerable inhibitory effect on Gram-negative bacteria. It has an inhibitory effect, but Staphylococcus aureus is resistant to erythromycin, and Staphylococcus aureus is one of the common pathogens that cause facial acne. In theory, it may be easier to relapse with erythromycin
In addition, topical anti-inflammatory or antibacterial preparations also generally have the problem of pigmentation after treatment, which affects the appearance of the face

Method used

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  • Metronidazole-erythromycin compound ointment for treating face acnes and preparation method thereof
  • Metronidazole-erythromycin compound ointment for treating face acnes and preparation method thereof
  • Metronidazole-erythromycin compound ointment for treating face acnes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Prescription composition:

[0026]

[0027] Preparation:

[0028] (1) Heat polyethylene glycol 1500 to 70°C to melt, add 1 / 3 of the formula amount of water for injection, stir and mix to obtain the mixed solution I, and keep the constant temperature at 70°C for later use;

[0029] (2) Add carboxymethylcellulose sodium, stearyl alcohol and sodium hyaluronate to 2 / 3 of the formula amount of water for injection, stir and mix to obtain mixed solution II;

[0030] (3) Add metronidazole, erythromycin, glutamine and serine into the mixed solution II, stir and mix to obtain the mixed solution III;

[0031] (4) Heat the mixed solution III in a water bath to 70°C, then add the mixed solution I to the mixed solution III, stir in the same direction to fully emulsify, and cool naturally to obtain the product.

Embodiment 2

[0033] Prescription composition:

[0034]

[0035]

[0036] Preparation:

[0037] (1) Heat polyethylene glycol 3000 to 80°C to melt, add 1 / 3 of the formula amount of water for injection, stir and mix well to obtain mixed solution I, and keep the temperature at 80°C for later use;

[0038] (2) Add carboxymethylcellulose sodium, glyceryl stearate and sodium hyaluronate to 2 / 3 of the formula amount of water for injection, stir and mix to obtain mixed solution II;

[0039] (3) Add metronidazole, erythromycin, glutamine and serine into the mixed solution II, stir and mix to obtain the mixed solution III;

[0040] (4) Heat the mixed solution III in a water bath to 80°C, then add the mixed solution I to the mixed solution III, stir in the same direction to fully emulsify, and cool naturally to obtain the product.

Embodiment 3

[0042] Prescription composition:

[0043]

[0044] Preparation:

[0045] (1) Heat polyethylene glycol 4000 to 70°C to melt, add 1 / 3 of the formula amount of water for injection, stir and mix to obtain the mixed solution I, and keep the constant temperature at 70°C for later use;

[0046] (2) Add sodium carboxymethylcellulose, sodium lauryl sulfate and sodium hyaluronate to 2 / 3 of the formula amount of water for injection, stir and mix to obtain mixed solution II;

[0047] (3) Add metronidazole, erythromycin, glutamine and serine into the mixed solution II, stir and mix to obtain the mixed solution III;

[0048] (4) Heat the mixed solution III in a water bath to 70°C, then add the mixed solution I to the mixed solution III, stir in the same direction to fully emulsify, and cool naturally to obtain the product.

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Abstract

The invention discloses a metronidazole-erythromycin compound ointment for treating face acnes and a preparation method thereof. The ointment comprises the following ingredients by weight percent: 1% of metronidazole, 0.2-0.6% of erythromycin, 0.08-0.1% of glutamine, 0.07-0.09% of serine, 40-65% of polyethylene glycol, 2-4% of an emulsifying agent, 1-2% of sodium carboxymethylcellulose, 1-2% of sodium hyaluronate, and the balance of water for injection. The primary active ingredients of the ointment disclosed by the invention are metronidazole and erythromycin, and glutamine and serine are also added to enhance the effectiveness of treating the face acnes. Moreover, the sodium hyaluronate is added to moisturize skin and alleviate damage of skin caused by active ingredients. All ingredients in the ointment achieve a synergistic effect, and good stability can be ensured without extra ingredients such as a stabilizer. Moreover, the effectiveness of the medicine is effectively improved, and the occurrence rate of side effects is reduced.

Description

technical field [0001] The invention relates to a compound ointment, in particular to a metronidazole erythromycin compound ointment for treating facial acne and a preparation method thereof. It belongs to the field of medical technology. Background technique [0002] Facial acne is pimples on the face. It is a very common skin disease. It is generally seen in teenagers around the age of 20, but there is no age limit. There are many types of facial acne, and severe ones can also suppurate, so they should be treated in time. The causes of facial acne include internal and external factors: internal factors include endocrine factors and genetic factors; external factors include improper diet, irregular life, improper use of cosmetics, and improper cleaning. In short, acne is a multifactorial disease, and it often grows repeatedly, which seriously affects the appearance of the face, which in turn leads to low self-esteem in patients and affects social interaction. [0003] Th...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/36A61K31/7048A61P17/10A61K31/4164A61K31/198
CPCA61K9/0014A61K9/06A61K31/198A61K31/4164A61K31/7048A61K47/36A61K2300/00
Inventor 侯俊领李春玲张梦璇侯羿翟学英
Owner 翟学英
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