Ceftriaxone sodium and sulbactam sodium composition as well as medicinal preparation containing composition and application thereof

A technology for ceftriaxone sodium and sulbactam sodium, which is applied to pharmaceutical preparations and their application fields, can solve the problems of short validity period, poor efficacy, poor stability and the like, and achieve the effects of excellent stability and biological activity
CN106822147AActive Publication Date: 2017-06-13XIANGBEI WELMAN PHARMA CO LTD +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XIANGBEI WELMAN PHARMA CO LTD
Publication Date
2017-06-13

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Abstract

The invention provides a composition prepared from ceftriaxone sodium and sulbactam sodium as well as a medicinal preparation containing the composition and application thereof. The composition is characterized in that an X-ray powder diffraction analysis spectrum includes a specific diffraction range. The medicinal preparation containing the composition, which is provided by the invention, has better bacteriostatic activity and stability, therefore, is quite suitably used for the treatment of a bacterial infection, and particularly applicable to the treatment of a refractory disease which is caused by neisseria gonorrhoeae drug-fast to multiple antibiotics (beta-lactam, tetracycline, macrolide, fluoroquinolone or aminoglycoside) and infects a urogenital system.
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Description

technical field

[0001] The invention relates to a composition, in particular to a composition composed of ceftriaxone sodium and sulbactam sodium. The present invention also relates to pharmaceutical preparations comprising the composition and applications thereof. Background technique

[0002] Ceftriaxone is a third-generation cephalosporin antibiotic, and its sodium salt is commonly used clinically. Ceftriaxone sodium has good antibacterial activity against a variety of Gram-negative bacteria and some Gram-positive bacteria (such as E. Infectious diseases, but not sensitive to methicillin-resistant Staphylococcus aureus (MRSA), Enterobacter cloacae, etc., resulting in certain restrictions on its use. Sulbactam is a β-lactamase inhibitor. In the prior art, someone made sulbactam sodium and ceftriaxone sodium into a compound preparation, which improved the antibacterial spectrum of ceftriaxone and the sensitivity to drug-resistant bacteria.

[0003] Stable drug quality i...

Claims

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