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A polyamino acid/mos 2 Preparation methods and applications of nanoclusters

A polyamino acid and nano-cluster technology, which is applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problem of low photothermal conversion efficiency of nano-clusters and synthesis efficiency of nano-clusters. Low cost, cumbersome surface modification, etc., to achieve excellent photothermal conversion performance, good cell compatibility, and good colloidal stability

Active Publication Date: 2019-11-29
UNIV OF SHANGHAI FOR SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a polyamino acid / MoS 2 The preparation method and application of nanoclusters, the polyamino acid / MoS 2 The preparation method and application of nanoclusters should solve the problems of MoS in the prior art 2 Low synthesis efficiency of nanoclusters, use of toxic solvents in the synthesis process, cumbersome surface modification, and low photothermal conversion efficiency of nanoclusters

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  • A polyamino acid/mos <sub>2</sub> Preparation methods and applications of nanoclusters
  • A polyamino acid/mos <sub>2</sub> Preparation methods and applications of nanoclusters
  • A polyamino acid/mos <sub>2</sub> Preparation methods and applications of nanoclusters

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Experimental program
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Embodiment 1

[0029] Weigh 0.1 g ammonium tetrathiomolybdate and 1 g γ-PGA (molecular weight 1000kDa), mix with 20 mL distilled water, and stir at room temperature for 0.5 h to obtain a clear and transparent solution. The resulting solution was transferred to a 100 mL volume stainless steel reaction kettle lined with p-polyphenylene and sealed. Put the reaction kettle into a high-temperature oven for heat treatment at 220 °C for 12 h. After cooling down to room temperature naturally, the reaction mixture was centrifuged and washed three times with 50% (volume fraction, the same below) ethanolamine solution and distilled water to obtain γ- PGA / MoS 2 nanoclusters.

Embodiment 2

[0031] Observe the microscopic morphology of the material by TEM: Disperse an appropriate amount of nano-clusters in absolute ethanol, and disperse evenly by ultrasonic, then immerse the copper mesh coated with carbon film in the above-mentioned absolute ethanol. After the samples were naturally dried, they were observed and photographed by TEM, and the operating voltage of TEM was 200 kV. The diameters of nanoclusters were measured with Image J 1.40G software (http: / / rsb.info.nih.gov / ij / download.html, National Institutes of Health, USA) (at least 50 measurements per sample). TEM observation results ( figure 1 a) shows that the obtained γ-PGA / MoS 2 Nanoclusters have a sheet structure. The diameter of nanoclusters was measured with Image J 1.40G software (http: / / rsb.info.nih.gov / ij / download.html, National Institutes of Health, USA) (at least 50 different cluster particles were measured), γ-PGA / MoS 2 The diameter of the nanoclusters is 197.3 ± 26.6 nm.

Embodiment 3

[0033] The valence of Mo and S elements in nanoclusters was characterized by ESCAlab250 X-ray photoelectron spectrometer (XPS) from Thermal Scientific Company. The excitation source is monochromator Al Kα X-rays (λ = 0.8339 nm), the energy is 1486eV, the linewidth is 0.9 eV, and the power is 150 W. The binding energy was corrected with the 1s peak of C (284.8 eV). The crystal structure of the XRD diffraction pattern of the nanoclusters was investigated using XRD (Rigaku D / max-2200 PC, Japan). With Cu2Kα rays as the light source, the operating voltage is 40 kV, the current is 200 mA, and the scanning angle (2θ) ranges from 3° to 70°. Using FTIR (Nicolet Nexus 670 infrared spectrometer) and UV-Vis-NIR (Lambda 25, Perkin Elmer Company, USA) 2 Nanocluster Characterization. For FTIR characterization, a small amount of powder and PGA powder (control group) were taken, mixed with dry KBr powder, ground evenly, and then compressed into tablets. Placed on a Nicolet Nexus 670 infrar...

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Abstract

The invention provides a preparation method for a polyamino acid / MoS2 nano-cluster. The method comprises the following steps: simultaneously dissolving molybdenum source, sulfur source and polyamino acid in distilled water, wherein the concentration of the molybdenum source is 1-100mg / mL, the concentration of the sulfur source is 1-100mg / mL and the concentration of polyamino acid is 1-100mg / mL; uniformly stirring, and then transferring the acquired solution into a reaction kettle and performing sealing reaction for 12-24 hours at 150-250 DEG C; washing the acquired product with cholamine aqueous solution and distilled water, thereby acquiring the polyamino acid / MoS2 nano-cluster. The preparation method provided by the invention is simple in process; no toxic or harmful solvent is used; the product is easily acquired; the surface modification of the nano-cluster can be synchronously realized; the prepared polyamino acid / MoS2 nano-cluster has excellent colloidal stability, photo-thermal conversion performance and biocompatibility; the polyamino acid / MoS2 nano-cluster is expected to be further used for providing a new thought for a clinic tumor thermotherapy material.

Description

technical field [0001] The invention belongs to the field of biological nanomaterials, specifically a polyamino acid / MoS 2 Preparation methods and applications of nanoclusters. Background technique [0002] Cancer is one of the most dangerous diseases currently threatening human health. In recent years, the incidence of tumors and the mortality caused by tumors have shown an upward trend. Traditional tumor treatment methods include common surgical treatment, radiotherapy, and chemotherapy. For patients with early-stage tumors, surgical treatment can achieve better results. However, for advanced patients, surgery and radiotherapy lose their therapeutic value, and chemotherapy drugs are often used for treatment. However, there are a series of disadvantages in chemotherapy, such as high toxicity and side effects, and drug resistance that can cause tumors. Photothermal therapy is a micro / non-invasive tumor treatment method that has emerged in recent years. It uses materials ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K41/00A61K47/62A61P35/00
CPCA61K41/0052
Inventor 王世革赵九龙吴陈瑶李莉娜周春华邹多武
Owner UNIV OF SHANGHAI FOR SCI & TECH
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