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Preparation method of mesoporous bioactive glass nanotube stent

A technology of bioactive glass and nanotubes, which is applied in the field of preparation of nanobiomedical materials, can solve the problems of no mesoporous structure in the tube wall, low bioactivity of polymer materials, easy to cause inflammation, etc., and achieves wide application prospects and large ratio The effect of surface area

Inactive Publication Date: 2017-06-30
TIANJIN UNIV
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Problems solved by technology

[0003] At present, the widely used bone tissue engineering scaffold materials are mainly divided into two categories: polymer materials and inorganic materials. The bioactivity of polymer materials is very low, and it is difficult to meet the requirements of human mechanical properties during the degradation process, and the degradation products are acidic. It is easy to cause inflammation, etc., and its application is limited; bioactive inorganic materials (such as bioactive glass) have good biological activity, certain mechanical strength and good biocompatibility, etc., and have certain applications as bone tissue engineering materials prospect
In the prior art, precalcified bacterial cellulose ((Bacterial Cellulose, BC) is used as a template to prepare bioactive glass nanotubes, but the resulting bioglass nanotubes have no mesoporous structure

Method used

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  • Preparation method of mesoporous bioactive glass nanotube stent
  • Preparation method of mesoporous bioactive glass nanotube stent
  • Preparation method of mesoporous bioactive glass nanotube stent

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preparation example Construction

[0024] The preparation method of a mesoporous bioactive glass nanotube support proposed by the present invention uses silicate as a silicon source, calcium nitrate tetrahydrate or calcium chloride as a calcium source, and triethyl phosphate as a phosphorus source; Silicon-derived bacterial cellulose (Bacterial Cellulose, BC) and polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer (P123) are dual template agents, which are stirred in a water bath, hydrolyzed and polycondensed , the precursor hybrid material was prepared, and finally, the BC and P123 dual-template agent was removed by heat treatment technology, and the mesoporous bioactive glass nanotube scaffold was obtained. The method realizes the controllable preparation of the mesoporous bioactive glass nanotube scaffold, and the obtained product has the advantages of mesoporous, three-dimensional space network structure, uniform and adjustable wall thickness. The preparation process includes precur...

Embodiment 1

[0033] Embodiment 1: preparing a mesoporous bioactive glass nanotube scaffold with a wall thickness of about 6 nm, the specific steps are as follows:

[0034] 1) Prepare a mixed solution A with a molar concentration of 0.5M tetraethyl orthosilicate and absolute ethanol, and stir in a water bath at a temperature of 40°C and a stirring speed of 120r / min; under stirring conditions, soak BC in the above mixed solution In A, 10 mL of absolute ethanol corresponds to 25 mg of BC. After 2 days, the product was taken out, washed several times with absolute ethanol to remove excess precursor substances on the surface of the product, and BC with silicon source uniformly adsorbed on the surface and inside was obtained.

[0035] 2) Prepare a mixed solution B of absolute ethanol and distilled water with a volume ratio of 9:1, and stir in a water bath at a temperature of 40°C and a stirring speed of 120r / min; under stirring conditions, the surface obtained in the above step 1) and The BC wit...

Embodiment 2

[0039] Embodiment 2: preparing a mesoporous bioactive glass nanotube scaffold with a wall thickness of about 10 nm, specifically comprising the following steps:

[0040] It is basically the same as Example 1, except that the mixed solution A prepared in step 1) is a mixed solution A with a molar concentration of 0.7M tetraethyl orthosilicate and absolute ethanol; finally, a mesoporous, three-dimensional A bioactive glass nanotube scaffold with a spatial network structure and a wall thickness of 10nm.

[0041] Figure 2(a) and Figure 2(b) are the TEM and HRTEM photographs of the mesoporous bioactive glass nanotube scaffold prepared in Example 2 respectively, from Figure 2(a) it can be concluded that the mesoporous bioactive glass nanotube The wall thickness of the tube scaffold is 10 nm (indicated by the white straight line area), and its wall thickness is uniform and its structure is clear.

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Abstract

The invention discloses a preparation method of a mesoporous bioactive glass nanotube stent. The preparation method comprises the following steps: by taking silicate ester as a silicon source, taking tetrahydrated calcium nitrate or calcium oxide as a calcium source and taking triethyl phosphate as a phosphorus source, performing water bath stirring, hydrolysis and polycondensation on silicon source pre-adsorbed bacterial cellulose and a polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer which serve as a dual-template agent under the assistance of a sol-gel technology, thereby preparing a precursor hybrid material; removing the dual-template agent through a calcining thermal treatment technology, thereby obtaining the bioactive glass nanotube stent which is of a mesoporous and three-dimensional spatial network structure and has a uniform wall thickness. The preparation method disclosed by the invention can realize batch production and is high in production efficiency and environmentally-friendly; furthermore, the mesoporous bioactive glass nanotube stent has a large specific surface area, is of a hollow and three-dimensional spatial structure, is extremely high in pore volume and excellent in bioactivity and biocompatibility, and has wide application value in the field of bone tissue engineering.

Description

technical field [0001] The invention relates to the preparation of a nano biomedical material, in particular to a preparation method of a mesoporous bioactive glass nanotube support. Background technique [0002] The number of related bone diseases caused by trauma, infection, tumor resection, etc. is increasing day by day, which increases the demand for bone regeneration or bone replacement products. At present, the commonly used bone grafting methods mainly include autologous bone grafting and allogeneic bone grafting. Autologous bone grafting is the recognized gold standard in bone reconstruction surgery, with good histocompatibility and non-immunogenicity. However, the amount of autologous bone is limited and may be complicated by inflammation; whereas allograft bone grafting may lead to the spread of disease. It is generally believed that bone tissue engineering scaffolds are the most promising bone substitute products. [0003] At present, the widely used bone tissu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/10A61L27/56A61L27/50A61L27/20A61L27/18
CPCA61L27/10A61L27/18A61L27/20A61L27/50A61L27/54A61L27/56A61L2300/412A61L2430/02C08L1/02C08L71/02
Inventor 万怡灶肖健罗红林
Owner TIANJIN UNIV
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