A kind of glimepiride tablet and preparation method thereof
A technology for glimepiride tablets and urea tablets, which is applied in the field of medicine, can solve the problems of low bioavailability, large dissolution differences between tablets, and low solubility of insoluble drugs, and achieve simple preparation process and rapid drug dissolution Effect
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Embodiment 1
[0027]
[0028] Preparation Process:
[0029] Dissolve glimepiride in sodium hydroxide solution, add mesoporous silica, stir evenly, add glacial acetic acid to the solution under stirring condition, the compound of glimepiride and mesoporous silica is precipitated, Filter, dry at 60°C, then mix with microcrystalline cellulose and sodium carboxymethyl starch, mix evenly, add magnesium stearate, mix, and compress into tablets.
Embodiment 2
[0031]
[0032] Preparation Process:
[0033] Dissolve glimepiride in sodium hydroxide solution, add mesoporous silica, stir evenly, add glacial acetic acid to the solution under stirring condition, the compound of glimepiride and mesoporous silica is precipitated, Filtrate, dry at 65°C, then mix evenly with the mixed powder of microcrystalline cellulose and crospovidone, add magnesium stearate, mix, and compress into tablets.
Embodiment 3
[0035]
[0036] Preparation Process:
[0037] Dissolve glimepiride in sodium hydroxide solution, add mesoporous silica, stir evenly, add glacial acetic acid to the solution under stirring condition, the compound of glimepiride and mesoporous silica is precipitated, Filter, dry at 60°C, then mix with microcrystalline cellulose and sodium carboxymethyl starch, mix evenly, add magnesium stearate, mix, and compress into tablets.
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