Easily-disintegrated freeze-drying molding preparation having any form, and preparation method thereof

A technology of disintegrating agent and form, which is applied in the field of easily disintegrating freeze-dried preparations in any form and its preparation, which can solve the problems of no demoulding, single shape and single form of the preparation

Inactive Publication Date: 2017-07-21
董玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the lyophilized excipients on the market are single in form, and the molds used are traditional moulds, i.e. common groove molds. This traditional lyophilized excipient and its preparation method have the following disadvantages:
[0005] (1) The shape of the preparation is single. The reason is that the shape of the mold is fixed, and it can only be demoulded without demoulding or from one direction. No demoulding means that it is molded directly in a certain shape of packaging material, so it is rare to be spherical, Due to special shapes such as ellipsoid and irregular sphere, it is difficult to make special-shaped freeze-dried excipients due to traditional preparation methods
[0006] (2) The prepared tablet has sharp-edged edges, and many tablets with sharp-edged edges obtained after demolding enter the same package together and are prone to abrasion between the sharp-angled edges, resulting in inaccurate drug dosage
[0007] (3) Because of unidirectional filling, it is difficult to become a multi-layer structure, therefore, the preparation structure is single
[0008] (4) The three-dimensional freeze-dried preparation with special form is affected by water disintegration, which affects product experience

Method used

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  • Easily-disintegrated freeze-drying molding preparation having any form, and preparation method thereof
  • Easily-disintegrated freeze-drying molding preparation having any form, and preparation method thereof
  • Easily-disintegrated freeze-drying molding preparation having any form, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] A. Prepare a solution by mixing 1 liter of water, 100 g of VC powder, and 40 g of pullulan to form liquid 1;

[0082] B. Freeze liquid 1, and spray it with liquid nitrogen during the freezing process to form snowflake-like ice powder, which is component 2;

[0083] C, 40g dry powder of carboxymethyl starch, 30g dry powder of talcum powder, mix evenly, and fully mix with component 2 to form component 3;

[0084] D, component 3 is packed into spherical mold 11 quantitatively to form quantitative component 4, and add external force to carry out compaction;

[0085] E. Freeze-dry component 4 to form a freeze-dried whitening solid essence.

Embodiment 2

[0087] A. Add 1 liter of VE 100g, Tween 30g, mannitol 50g, carbomer 30g, and triethanolamine 50ml to form an emulsion to form liquid 1;

[0088] B. Freeze liquid 1, and during the freezing process, spray it with liquid nitrogen to form ice crystals, and further enter the low-temperature pulverizer for crushing until it passes through a 200-mesh sieve, which is component 2;

[0089] C. Mix 40 g dry powder of sodium carboxymethyl cellulose and 5 g dry powder of magnesium stearate evenly, and fully mix with component 2 to form component 3;

[0090] D, component 3 is packed into ellipsoidal mold quantitatively, forms quantitative component 4, and adds certain pressure, is pressed into component 4;

[0091] E. The compressed component 4 is lyophilized to form a lyophilized VE milk solid ointment 12 .

Embodiment 3

[0093] A. Add 200g of nano-grade pearl powder and 30g of xanthan gum to 1 liter of water to make a suspension, and disperse evenly to form liquid 1;

[0094] B. Freeze liquid 1, and after freezing, use a low-temperature pulverizer to physically crush it to form ice particles, which is component 2;

[0095] C. Mix 40g dry powder of low-substituted hydroxypropyl cellulose and 10g dry powder of tapioca starch evenly, mix with component 2 to form component 3

[0096] D, component 3 is packed into hemispherical mold quantitatively, forms quantitative component 4;

[0097] E. Freeze-dry component 4 to form a freeze-dried oral pearl powder health food.

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Abstract

The present invention relates to an easily-disintegrated freeze-drying molding preparation having any form, and a preparation method thereof, particularly to a freeze-drying molding preparation and a preparation method thereof, wherein water or a freeze-drying preparation raw liquid is completely stirred into ice sand during freezing, the remaining raw material and the remaining auxiliary material are further mixed into the ice sand, the obtained mixture is loaded into a certain mold, shaping is performed, freeze-drying is performed to obtain the easily-disintegrated freeze-drying molding preparation, and the obtained easily-disintegrated freeze-drying molding preparation has an any molding shape and mainly contains an active component, an adhesive and a disintegrating agent.

Description

technical field [0001] The present invention relates to an easily disintegrated freeze-dried preparation in any form and a preparation method thereof, in particular to a kind of smoothie made by fully stirring water or freeze-dried preparation stock solution during freezing, and further adding remaining raw and auxiliary materials Freeze-dried preparation product of arbitrary shape, mainly containing active ingredient, binder and disintegrating agent and its preparation method, which are prepared by mixing it into smoothie, filling it into a certain mold for shaping and freeze-drying. Background technique [0002] Freeze-drying excipient technology refers to adding a skeleton support agent and a binder to a flowable liquid, semi-solid or solid active ingredient, or the flowable liquid, semi-solid or solid itself contains a binder and a skeleton The support agent is then poured into a molding mold and shaped by a freeze-drying process. The preparation prepared by the freeze-d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K8/02A23L33/00A23L17/50A23L2/395A23C9/18
CPCA23C9/18A23L2/395A61K8/022A61K8/29A61K8/375A61K8/602A61K8/64A61K8/65A61K8/673A61K8/676A61K8/73A61K8/97A61K9/0056A61K9/19A61K9/2027A61K9/2054A61K9/2059A61K31/265A61K31/355A61K31/375A61K31/519A61K31/616A61K36/258A61K39/36A61K47/36A61Q1/12A61Q19/00A61Q19/02A61Q19/08A61K2300/00
Inventor 董玲
Owner 董玲
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