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Preparation method of Ag/ Ag-AgCl/ZnO composite hydrogel dressing for treating skin injury in photodynamic manner

A technology of composite hydrogel and photodynamic therapy, which is applied in the field of biomedical materials, can solve the problems of poor photocatalytic properties of pure zinc oxide nanomaterials, and achieve the effects of small implementation difficulty, simple preparation method, and favorable growth

Inactive Publication Date: 2017-07-28
HUBEI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the photocatalytic performance of pure ZnO nanomaterials is not good and needs to be modified

Method used

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  • Preparation method of Ag/ Ag-AgCl/ZnO composite hydrogel dressing for treating skin injury in photodynamic manner
  • Preparation method of Ag/ Ag-AgCl/ZnO composite hydrogel dressing for treating skin injury in photodynamic manner
  • Preparation method of Ag/ Ag-AgCl/ZnO composite hydrogel dressing for treating skin injury in photodynamic manner

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preparation example Construction

[0024] A method for preparing an Ag / Ag-AgCl / ZnO composite hydrogel dressing for photodynamic therapy of skin wounds, comprising the steps of:

[0025] S1. Dissolve 4-6g of sodium carboxymethylcellulose in 100mL of NaOH solution with a mass volume ratio of 2-4%, stir for 20-40min, and then drop 4-6mL of cross-linking agent epichlorohydrin into the aforementioned Stir in the mixed solution for 2-4 hours to obtain the mixed solution A for later use;

[0026] Preferably, in step S1, the crosslinking agent epichlorohydrin is slowly dropped into the aforementioned mixed solution with a constant pressure dropping funnel;

[0027] S2. After injecting the mixed liquid A prepared in step S1 into a glass mold, place it in an oven, pre-polymerize at 70-90°C for 1-2 hours to make a prepolymer, wash it, and then polymerize at 40-60°C for 18 ~30h to prepare carboxymethyl cellulose hydrogel;

[0028] Preferably, in step S2, the prepolymer is washed with deionized water for 3-5 times and the...

Embodiment 1

[0039] S1. Dissolve 5g of sodium carboxymethylcellulose in 100mL of NaOH solution with a mass volume ratio of 3%, stir for 30min, and then drop 6mL of crosslinking agent epichlorohydrin into the aforementioned mixed solution with a constant pressure dropping funnel Stir in medium for 2h to obtain mixed solution A for subsequent use;

[0040] S2. After injecting the mixed liquid A prepared in step S1 into a glass mold, place it in an oven, pre-polymerize at 80°C for 2 hours to make a prepolymer, wash the prepolymer 3 times with deionized water, and place it in the oven , and then polymerized at 50°C for 24 hours to prepare carboxymethyl cellulose hydrogel;

[0041] S3. Cut the carboxymethyl cellulose hydrogel prepared in step S2 as a carrier into a small disc with a diameter of 18mm, place it in deionized water for 12h, and then soak it in 100mL of 1.25mM silver nitrate solution for 12h , to load silver ions and silver chloride on the carrier, and irradiate with ultraviolet li...

Embodiment 2

[0047] S1. Dissolve 4g of sodium carboxymethylcellulose in 100mL of NaOH solution with a mass volume ratio of 4%, stir for 40min, then drop 5mL of crosslinking agent epichlorohydrin into the aforementioned mixed solution with a constant pressure dropping funnel Stir in medium for 3h to obtain mixed solution A for subsequent use;

[0048] S2. After injecting the mixed liquid A prepared in step S1 into a glass mold, place it in an oven, pre-polymerize at 70°C for 1 hour to make a prepolymer, wash the prepolymer 3 times with deionized water, and place it in the oven , and then polymerized at 60°C for 30 hours to prepare carboxymethyl cellulose hydrogel;

[0049] S3. Cut the carboxymethyl cellulose hydrogel prepared in step S2 as a carrier into a small disc with a diameter of 18mm, place it in deionized water for 12h, and then soak it in 100mL of 0.75mM silver nitrate solution for 6h , to load silver ions and silver chloride on the carrier, and irradiate with ultraviolet light wi...

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Abstract

A preparation method of Ag / Ag-AgCl / ZnO composite hydrogel dressing for treating skin injury in a photodynamic manner comprises the following steps: S1, dissolving 4-6 g of sodium carboxymethylcellulose in 100 mL of a NaOH solution with the mass volume ratio of 2-4%, stirring for 20-40 minutes, dropwise adding 4-6 mL of epoxy chloropropane as a crosslinking agent into the mixed solution, and stirring for 2-4 hours to obtain mixed liquid A for subsequent use; S2, preparing carboxymethylcellulose hydrogel; S3, preparing Ag / Ag-AgCl composite hydrogel; and S4, preparing Ag / Ag-AgCl / ZnO composite hydrogel. The preparation method of the Ag / Ag-AgCl / ZnO composite hydrogel dressing for treating skin injury in the photodynamic manner has the advantages that silver nanoparticles and silver / silver chloride composite nano particles are prepared by an ultraviolet reduction method, oxidized nanorods are deposited with alkali, heating is not required, meanwhile, harmful gas is not generated, and the preparation method is economical and environmentally friendly; the preparation method is simple, investment on equipment is low, consumed resources are less, and implementation difficulty is low; and antibacterial activity is improved, an immune system is stimulated to resist bacteria cooperatively in a slow release manner, and healing of skin injury is promoted.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for preparing an Ag / Ag-AgCl / ZnO composite hydrogel dressing for photodynamic therapy of skin wounds. Background technique [0002] Biomedical materials are the basis for the study of artificial organs and medical devices, and are used for diagnosing, treating diseases, surgically repairing or replacing damaged tissues and organs, or enhancing their functions without adversely affecting the organism. . As a biomedical material, it should be non-toxic, non-sensitizing, non-irritating, non-genotoxic, non-carcinogenic and other adverse reactions to the human body. [0003] Skin damage from surgery, heat, radiation, and chemical agents can lead to bacterial infections caused by microorganisms, especially Escherichia coli and Staphylococcus aureus. Rapid treatment of this type of wound, which requires a moist environment for healing, has attracted widespread att...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61K41/00A61K9/06A61K47/38A61P31/04A61P17/02A61K33/38A61K33/30
CPCA61L26/008A61K9/06A61K33/30A61K33/38A61K41/0057A61K47/38A61L26/0023A61L26/0066A61L2300/102A61L2300/104A61L2300/404A61L2300/412A61L2300/45A61L2300/624A61K2300/00
Inventor 吴水林毛丛杨刘想梅
Owner HUBEI UNIV
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