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Acetazolamide tablets and preparation method thereof

A technology of acetazolamide tablet and acetazolamide, which is applied in the field of acetazolamide tablet and preparation thereof, can solve the problems of long disintegration time, low bioavailability, difficult acetazolamide and the like of the tablet, so as to improve the bioavailability , good efficacy, rapid dissolution effect

Inactive Publication Date: 2017-08-18
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, acetazolamide is insoluble in water, which makes the tablet have disadvantages such as long disintegration time, slow onset of action, low bioavailability, etc., thus affecting the efficacy of the drug.

Method used

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  • Acetazolamide tablets and preparation method thereof
  • Acetazolamide tablets and preparation method thereof
  • Acetazolamide tablets and preparation method thereof

Examples

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preparation example Construction

[0036] The present invention also provides a kind of preparation method of acetazolamide tablet, comprises the following steps:

[0037] a) Sieve acetazolamide, lactose, corn starch, pregelatinized starch, povidone, sucrose, sodium starch glycolate, magnesium stearate, and disintegrating materials for later use; and divide the corn starch into the first corn starch and a second cornstarch;

[0038] b) Weigh acetazolamide, lactose, the first corn starch, and pregelatinized starch, and put them into an intelligent automatic high-efficiency wet granulator for dry mixing for 5-15 minutes; then add povidone, sucrose, and purified water , granulation;

[0039] c) sizing and drying the granules prepared in step b) to obtain acetazolamide dry granules;

[0040] d) Add the acetazolamide dry granules obtained in step c), sodium starch glycolate, and the second cornstarch into a multidirectional motion mixer, and after mixing for 10 to 15 minutes, add magnesium stearate and disintegrat...

Embodiment 1

[0050]Pass acetazolamide through a 20-mesh sieve, and pass through a 30-mesh sieve for lactose, corn starch, pregelatinized starch, povidone, sucrose, sodium starch glycolate, magnesium stearate, and disintegrating materials, and set aside; It is 29.88g of the first cornstarch and 5.12g of the second cornstarch; weigh 200g of acetazolamide, 135g of lactose, the first cornstarch, and 14g of pregelatinized starch, and put them into an intelligent automatic high-efficiency wet granulator to dry Mix for 5 minutes; then add 15g of povidone, 12g of sucrose, and 60g of purified water to granulate; put the prepared granules into a vibrating sieve with a mesh size of 14 for granulation, and then dry at 70°C for 4 minutes after granulation , to obtain acetazolamide dry granules; the obtained acetazolamide dry granules, 22g sodium starch glycolate, and the second cornstarch were added to a multi-directional motion mixer, and after mixing for 12min, 2g magnesium stearate and 2g sulfuric ac...

Embodiment 2

[0052] Pass acetazolamide through a 20-mesh sieve, and pass through a 30-mesh sieve for lactose, corn starch, pregelatinized starch, povidone, sucrose, sodium starch glycolate, magnesium stearate, and disintegrating materials, and set aside; It is 43.37g of the first cornstarch and 6.63g of the second cornstarch; weigh 300g of acetazolamide, 175g of lactose, the first cornstarch, and 16g of pregelatinized starch, and put them into an intelligent automatic high-efficiency wet granulator to dry Mix for 8 minutes; then add 5g of povidone, 7g of sucrose, and 65g of purified water to granulate; put the prepared granules into a vibrating sieve with a mesh size of 14 for granulation, and then dry at 70°C for 5 minutes after granulation , to obtain acetazolamide dry granules; the obtained acetazolamide dry granules, 18g sodium starch glycolate, and the second cornstarch were added to a multidirectional motion mixer, and after mixing for 107min, 3g magnesium stearate, 3.64g Calcium sul...

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Abstract

The invention discloses acetazolamide tablets and a preparation method thereof. The acetazolamide tablets comprise 200-300 parts by weight of acetazolamide, 100-200 parts by weight of lactose, 30-45 parts by weight of corn starch, 10-20 parts by weight of pregelatinized starch, 5-15 parts by weight of povidone, 10-30 parts by weight of carboxymethyl starch sodium, 1-4 parts by weight of magnesium stearate and 4-10 parts by weight of a disintegrating material. The acetazolamide tablets disclosed by the invention have a good curative effect on glaucoma; the acetazolamide tablets can be quickly dissolved out, and are high in dissolving out degree and fast to take effect, so that the bioavailability is improved and side effects are reduced. In addition, the acetazolamide tablets prepared by the formula are low in cost and good in efficacy, so that the treatment cost is lowered.

Description

Technical field [0001] The present invention relates to the field of acetazolamide, and in particular to an acetazolamide tablet and a preparation method thereof. Background technique [0002] Acetazolamide is a carbonic anhydrase inhibitor, mainly used to reduce intraocular pressure and inhibit the activity of carbonic anhydrase in the ciliary body skin, thereby reducing the production of aqueous humor and lowering intraocular pressure. It is suitable for the treatment of various types of glaucoma. Such as open-angle (chronic simple) glaucoma, angle-closure glaucoma, etc. However, acetazolamide is poorly soluble in water, causing the tablets to have shortcomings such as long disintegration time, slow onset of action, and low bioavailability, thus affecting the efficacy of the drug. Contents of the invention [0003] In view of this, the object of the present invention is to provide an acetazolamide tablet and a preparation method thereof, which can shorten the disintegra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/433A61K47/36A61P27/06
CPCA61K31/433A61K9/2018A61K9/2027A61K9/2059A61K9/2095
Inventor 高煜操铖
Owner HUAYI PHARMA ANHUI CO LTD
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