Macromolecule hydrogel dry glue sponge with super water absorption, and preparation method and application thereof

Abstract

The invention relates to macromolecule hydrogel dry glue sponge with super water absorption, and a preparation method and application thereof. The sponge is stereoscopic netted porous sponge which takes chitosan as a framework, a super hydroscopic polymer as a branch chain and a macromolecule or polymer with a flexible structure as a cross-linking agent. The sponge is prepared through a one-pot process. The product has a porous structure and a super hydroscopic feature; after the sponge absorbs water, an overall structure and a certain mechanical strength are still kept; the material can be used for first-aid hemostasis of larger arteriovenous hemorrhage; and the effect is better than that of the present material in the market. The macromolecule hydrogel dry glue sponge with super water absorption, provided by the invention, has the advantages of simple preparation process, low cost, obvious hemostatic effect, high safety, no heat generation, no residue, obvious medical value and industrial potential.

Description

technical field [0001] The invention relates to a biological material for emergency hemostasis, in particular to a superabsorbent polymer hydrogel xerogel sponge for emergency hemostasis. Background technique [0002] Hemostasis is an important part of emergency medical treatment, especially in the first aid of war and trauma caused by harsh war environments and complex emergencies, it is particularly important to achieve rapid and effective hemostasis. Emergency hemostatic agents are different from general hemostatic agents that are usually used clinically. The application timing is more urgent, and the operators are often not professional rescuers. Therefore, the requirements for portability, ease of use, and even storage are more stringent. An ideal first-aid hemostatic agent should meet the following conditions simultaneously: ①Rapidly achieve hemostatic effect on large arteries and veins within 2 minutes. ②It is convenient to use anytime and anywhere, without mixing or...

AI Technical Summary

Problems solved by technology

When they are used in the hospital, the hemostatic effect is acceptable, but there are obvious shortcomings when used in self-rescue and mutual rescue: for example, fibrin glue is derived from blood, the cost is high, and it is easy to infect diseases; collagen relies solely on the activation of platelets to stop bleeding , the hemostatic effect is limited, and the mechanical strength and tissue adhesion are poor; porous zeolite and Trauma DEX will release a large amount of heat energy after absorbing blood water, which will cause tissue burns; carboxymethylcellulose soluble gauze cannot degrade on the wound surface, and the hemostatic ability is limited

These inventions are all aware of the significant blood coagulation effect brought about by simple water absorption and concentration, but are limited by factors such as process and dosage form, and have not exerted the ideal hemostatic effect

The materials disclosed in patent ZL 03153260.8 and patent ZL 200410096825.4 are not biodegradable because sodium polyacrylate or polyacrylamide superabsorbent molecules are not biodegradable, so they are easily washed away by blood flow when bleeding arteries or veins are injured. The water absorption is quickly saturated, the hemostatic effect is limited, and it is difficult to clean up after use; the superabsorbent sodium polyacrylate grafted chitosan component in the material disclosed in patent ZL201110044474.2 is only one component in the material, making the material The overall water absorption effect is greatly reduced

None of the superabsorbent polymer modified macromolecules disclosed in the above patents can solve the dosage form problem. The prepared materials are in the form of powder or doped with powder, which not only limits the function of the material as a whole, but also brings cleaning difficulties and residual problems in the body.

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