Pyrazolyl-oxa(thia)diazole compound containing pyridinium salt, and preparation method and application thereof
A technology of azole compounds and pyrazole oxadiazoles, which is applied in the field of pyrazole oxadiazole compounds and their preparation, and can solve problems such as inactivity
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[0023] Example 1 of the present invention: target compound 10-(2-thioether-5-(1phenyl-2-trifluoromethyl)pyrazolyl)-1,3,4-oxadiazole-decyl-1 - Preparation of pyridinium bromide salt
[0024] Dissolve 0.5g 2-(10-bromodecyl)thioether-5-(1phenyl-2-trifluoromethyl)pyrazolyl-1,3,4-oxadiazole in 5mL pyridine, 50℃ The reaction was carried out for 6h, desolventized, and purified by column chromatography to obtain 0.53g of yellow liquid with a yield of 92.0%.
[0025] Refer to Example 1 for the synthesis of thioether and oxyether target compounds.
[0026] The structures, hydrogen NMR, carbon and fluorine spectra and mass spectrometry data of some of the synthesized pyrazole dioxa (thi) diazole compounds containing pyridine salts are shown in Table 1, and the physicochemical properties are shown in Table 2.
[0027] H NMR and C NMR data of some compounds in Table 1
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[0033] Table 2 Physicochemical properties of some target c...
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