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Monodisperse porous hydroxyapatite microsphere, preparation method and application of microsphere

A hydroxyapatite and monodisperse technology, which is applied in chemical instruments and methods, phosphorus compounds, and other chemical processes, can solve the problems of complex preparation process, uneven particle size distribution of microspheres, and low yield, and achieve the goal of preparing The effect of simple process, flexible and controllable pore size, and uniform pore distribution

Pending Publication Date: 2017-09-08
SUZHOU KNOWLEDGE & BENEFIT TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many problems in the current method of preparing hydroxyapatite microspheres, such as: uneven particle size distribution of microspheres, low yield and complicated preparation process, etc.

Method used

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  • Monodisperse porous hydroxyapatite microsphere, preparation method and application of microsphere

Examples

Experimental program
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Effect test

Embodiment 1

[0029] A kind of monodisperse porous hydroxyapatite microsphere, comprises the following steps:

[0030] (1) preparing porous polymer microspheres with a particle size of 5 μm and CV=3.2%;

[0031] (2) 100 grams of porous polymer microspheres were placed in 120 grams of water, and ammonia water was added while stirring, so that the system was adjusted to pH=10-11 to obtain solution A;

[0032] (3) Weighing Ca(NO 3 ) 2 .4H 2 O and (NH 4 ) 2 HPO 4 Dissolve in 80 grams of water, according to the ratio Ca: P = 1.67, to obtain solution B;

[0033] (4) Add B dropwise to A, and continue to react for 24 hours after the dropwise addition to obtain solution C;

[0034] (5) filter C, obtain polymer-hydroxyapatite composite microspheres after washing and drying;

[0035] (6) The polymer-hydroxyapatite composite microspheres are heated to 650°C and calcined for 6 hours to remove the organic polymers and form porous hydroxyapatite microspheres.

[0036] The porous polymer microsphe...

Embodiment 2

[0039] A kind of monodisperse porous hydroxyapatite microsphere, comprises the following steps:

[0040] (1) preparing porous polymer microspheres with a particle size of 2 μm and CV=3.1%;

[0041] (2) 50 grams of porous polymer microspheres were placed in 70 grams of water, and ammonia water was added while stirring, so that the system was adjusted to pH=10-11 to obtain solution A;

[0042] (3) Weighing Ca(NO 3 ) 2 .4H 2 O and (NH 4 ) 2 HPO 4 Dissolve in 50 grams of water, according to the ratio Ca: P = 2.37, to obtain solution B;

[0043] (4) Add solution B dropwise to solution A, and after the dropwise addition, continue to react for 24 hours at 70-80° C. to obtain solution C;

[0044] (5) filter solution C, obtain polymer-hydroxyapatite composite microspheres after washing and drying;

[0045] (6) The polymer-hydroxyapatite composite microspheres are heated to 550° C. and calcined for 6 hours to remove the organic polymers and form porous hydroxyapatite microsphere...

Embodiment 3

[0049] A kind of monodisperse porous hydroxyapatite microsphere, comprises the following steps:

[0050] (1) preparing porous polymer microspheres with a particle size of 500 μm and CV=3.2%;

[0051] (2) 100 grams of porous polymer microspheres were placed in 120 grams of water, and ammonia water was added while stirring, so that the system was adjusted to pH=10-11 to obtain solution A;

[0052] (3) Weighing Ca(NO 3 ) 2 .4H 2 O and (NH 4 ) 2 HPO 4 Dissolve in 80 grams of water, according to the ratio Ca: P = 1.67, to obtain solution B;

[0053] (4) Add solution B dropwise to solution A, and continue to react at 50° C. for 24 hours after the dropwise addition to obtain solution C;

[0054] (5) filter solution C, obtain polymer-hydroxyapatite composite microspheres after washing and drying;

[0055](6) The polymer-hydroxyapatite composite microspheres were heated to 800° C. for 6 hours and calcined to remove the organic polymers, resulting in porous hydroxyapatite micros...

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Abstract

The invention discloses a monodisperse porous hydroxyapatite microsphere, a preparation method and an application of the microsphere. The preparation method comprises the following steps of: (1) introducing a porous high polymer microsphere into water, adding alkali during stirring after uniform dispersion, regulating PH (potential of hydrogen) to be 10-11 to form a solution A, (2) introducing a calcium source and a phosphorus source into the water to form a solution B, (3) gradually dropwise adding the solution B into the solution A, continuing reaction after dropwise adding to form a solution C, (4) filtering the solution C, and performing washing and drying to form a high polymer-hydroxyapatite composite microsphere, and (5) calcining the high polymer-hydroxyapatite composite microsphere to form the porous hydroxyapatite microsphere. The hydroxyapatite microsphere is controllable and uniform in particle size and controllable in aperture, a preparation technology is simple, and a reaction condition is easy to control. The microsphere is suitable for large-scale production and can be widely applied to the fields of bioseparation, tissue engineering and the like.

Description

technical field [0001] The invention relates to the technical field of hydroxyapatite microspheres, in particular to a monodisperse porous hydroxyapatite microsphere, a preparation method and an application thereof. Background technique [0002] As an ideal bone repair material, hydroxyapatite mainly exists in hard tissues such as human bones and teeth. It is an important inorganic component and has the advantages of good osteoconductivity, bioactivity and biocompatibility. Porous hydroxyapatite microspheres have been widely used in tissue engineering and drug separation due to their low relative density, high specific surface area, and light weight. [0003] At present, the methods for preparing hydroxyapatite microspheres mainly include microemulsion method and spray drying method. Chinese patent (Application No. 200910104114.x) discloses a method for preparing nano-hydroxyapatite / polylactic acid composite microspheres. Nano-hydroxyapatite microspheres are prepared by ult...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61L27/56A61L27/12B01J20/28B01J20/04B01J20/30B01D15/08
CPCA61L27/12A61L27/56B01D15/08B01J20/048C01B25/325B01J20/28004B01J20/28019B01J20/28054C01P2006/16C01P2006/14C01P2004/61C01P2004/52C01P2004/32C01P2004/03
Inventor 阳承利黄功卿
Owner SUZHOU KNOWLEDGE & BENEFIT TECH CO LTD
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