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Novel preparation method of crosslinking modified starch microspheres

A technology of starch microspheres and cross-linking modification, which is used in pharmaceutical formulation, surgery, drug delivery and other directions, can solve the problems of poor product performance, high energy consumption, poor particle size control of starch microspheres, etc., to improve product performance , high transparency, shortening the effect of cross-linking reaction time

Active Publication Date: 2017-09-12
ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The various existing methods also have the disadvantages of poor particle size control of the prepared starch microspheres, high energy consumption, and poor product performance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Take modified starch cationic starch as raw material, weigh 20g, use 1% NaOH solution to prepare a modified starch solution with a concentration of 30% g / ml, and add polyvinyl alcohol solution as a modifier, polyethylene The weight ratio of alcohol to cationic starch is 1:20;

[0032] (2) Add 0.5% span80 emulsifier in the liquid paraffin, add the modified starch solution prepared in step (1) to the liquid paraffin, the weight ratio of the modified starch solution to the oil phase is 1:20, and then shear Machine high-speed emulsification, the emulsification speed is 500rpm, and the time is 20 minutes;

[0033](3) After the emulsification in step (2) is completed, add a cross-linking agent divinyl sulfone (DVS) with a mass percentage of 0.2% in the oil phase, stir at room temperature for 5 hours to carry out the cross-linking reaction, and leave to stand for stratification after completion;

[0034] (4) Remove the oil phase layer, wash the microspheres with ethyl ace...

Embodiment 2

[0037] (1) Take modified starch anionic starch as raw material, weigh 20g, prepare a modified starch solution with a concentration of 5% g / ml, and add polyvinyl alcohol solution as a modifying agent, the weight ratio of polyvinyl alcohol to anionic starch 1:100;

[0038] (2) Add 10% emulsifier Pingping plus O in the vegetable oil soybean oil, add the modified starch solution prepared by step (1) in the soybean oil, the weight ratio of the modified starch solution and the oil phase is 1:1, and then High-speed emulsification by a shearing machine, the emulsification speed is 2000rpm, and the time is 10 minutes;

[0039] (3) After the emulsification in step (2) is completed, add a cross-linking agent sodium tetraborate decahydrate solution with a mass percentage of 2% in the oil phase, stir at room temperature for 1 hour to carry out the cross-linking reaction, and leave to stand for stratification after completion;

[0040] (4) Remove the oil phase layer, wash the microspheres ...

Embodiment 3

[0043] (1) Take modified starch phosphate starch as raw material, weigh 20g, prepare a modified starch solution with a concentration of 10% g / ml, and add polyvinyl alcohol solution as a modifying agent, the mixture of polyvinyl alcohol and phosphate starch The weight ratio is 1:50;

[0044] (2) Add 1% Tween 80 emulsifier in n-hexane, add the modified starch solution prepared in step (1) into n-hexane, the weight ratio of modified starch solution to oil phase is 1:2, and then Shearing machine high-speed emulsification, the emulsification speed is 1000rpm, and the time is 15 minutes;

[0045] (3) After the emulsification in step (2) is completed, add a cross-linking agent divinyl sulfone (DVS) with a mass percentage of 1% in the oil phase, stir at room temperature for 2 hours to carry out the cross-linking reaction, and leave to stand for stratification after completion;

[0046] (4) Remove the oil phase layer, wash the microspheres with ethyl acetate multiple times to remove t...

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Abstract

The invention discloses a novel preparation method of crosslinking modified starch microspheres. The novel preparation method of the crosslinking modified starch microspheres comprises the following steps: firstly, using modified starch as a raw material, and preparing a modified starch solution with the concentration of 5 to 30 percent g / ml; secondly, adding a certain amount of polyvinyl alcohol solution as a modifier, adding the prepared modified starch solution into an oil phase containing an emulsifier; thirdly, carrying out high speed emulsification by a shearing machine, wherein the emulsifying speed is 500 to 2000rpm and the time is 10 to 20 minutes, and the like. According to the novel preparation method disclosed by the invention, a unique cross-linking agent which is divinyl sulfone (DVS) or sodium tetraborate decahydrate is adopted and the existing cross-linking problems are greatly improved, thereby obtaining a more stable and rapid crosslinking reaction and better product performance.

Description

technical field [0001] The invention discloses a chemical preparation method, in particular to a novel preparation method of cross-linked modified starch microspheres. Background technique [0002] Starch is a natural polymer compound produced by plants through photosynthesis. It is the second largest renewable resource after cellulose and an important basic raw material for green chemical industry. However, natural starch generally has disadvantages such as poor solubility, poor dispersibility, poor film-forming property, easy aging and poor peptization stability, which seriously restrict its application in various industries. In order to improve the performance of native starch and expand its application range, chemical, physical, enzymatic or compound modification methods are used to introduce new functional groups on starch molecules or change the size of starch molecules and granule properties to make them more suitable for certain industries. application requirements....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08L3/04C08L29/04C08L3/06C08L3/08A61L24/00A61L24/06A61L24/08
CPCA61L24/001A61L24/06A61L24/08C08J3/245A61L2400/04C08J2303/06C08J2303/04C08J2303/08C08J2429/04C08L3/04C08L3/06C08L3/08C08L29/04
Inventor 张治国索艳格黄伟孙伟庆
Owner ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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