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A kind of preparation method of cross-linked modified starch microspheres

A technology of starch microspheres and cross-linking modification, which is used in pharmaceutical formulation, surgery, drug delivery, etc., can solve the problems of poor control of starch microsphere particle size, high energy consumption, poor product performance, etc., and shorten the cross-linking. Response time, high transparency, and the effect of improving product performance

Active Publication Date: 2022-07-12
ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The various existing methods also have the disadvantages of poor particle size control of the prepared starch microspheres, high energy consumption, and poor product performance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Take modified starch cationic starch as raw material, weigh 20 g, use 1% NaOH solution to prepare a modified starch solution with a concentration of 30% g / ml, and add polyvinyl alcohol solution as modifier, polyethylene The weight ratio of alcohol to cationic starch is 1:20;

[0032] (2) adding 0.5% span80 emulsifier to the liquid paraffin, adding the modified starch solution prepared in step (1) to the liquid paraffin, the weight ratio of the modified starch solution to the oil phase is 1:20, and then shearing High-speed emulsification machine, the emulsification speed is 500rpm, and the time is 20 minutes;

[0033](3) after the emulsification in step (2) is completed, add a cross-linking agent divinyl sulfone (DVS) with a mass percentage of 0.2% in the oil phase, stir at room temperature for 5h to carry out the cross-linking reaction, and stand for stratification after completion;

[0034] (4) Remove the oil phase layer, wash the microspheres several times with e...

Embodiment 2

[0037] (1) take modified starch anionic starch as raw material, take by weighing 20g, prepare the modified starch solution with concentration of 5% g / ml, and add polyvinyl alcohol solution as modifier, the weight ratio of polyvinyl alcohol to anionic starch is 1:100;

[0038] (2) adding 10% of emulsifier peregrine to the vegetable oil soybean oil , adding the modified starch solution prepared in step (1) to the soybean oil, the weight ratio of the modified starch solution and the oil phase is 1:1, and then High-speed emulsification by shearing machine, emulsification speed is 2000rpm, time is 10 minutes;

[0039] (3) after the emulsification in step (2) is completed, add a cross-linking agent sodium tetraborate decahydrate solution with a mass percentage of 2% in the oil phase, stir at room temperature for 1 h to carry out the cross-linking reaction, and stand for stratification after completion;

[0040] (4) Remove the oil phase layer, wash the microspheres several times wit...

Embodiment 3

[0043] (1) Take modified starch phosphate ester starch as raw material, weigh 20 g, prepare a modified starch solution with a concentration of 10% g / ml, and add polyvinyl alcohol solution as a modifier, the mixture of polyvinyl alcohol and phosphate ester starch The weight ratio is 1:50;

[0044] (2) 1% Tween 80 emulsifier is added in n-hexane, the modified starch solution prepared in step (1) is added to n-hexane, the weight ratio of modified starch solution and oil phase is 1:2, and then The shearing machine is used for high-speed emulsification, the emulsification speed is 1000rpm, and the time is 15 minutes;

[0045] (3) after the emulsification in step (2) is completed, add the cross-linking agent divinyl sulfone (DVS) with a mass percentage of 1% in the oil phase, stir at room temperature for 2h to carry out the cross-linking reaction, and stand for stratification after completion;

[0046] (4) Remove the oil phase layer, wash the microspheres several times with ethyl a...

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Abstract

The invention discloses a novel preparation method of cross-linked modified starch microspheres. The alcohol solution is used as a modifier, and the prepared modified starch solution is added to the oil phase containing the emulsifier, and then emulsified at a high speed by a shearing machine. The emulsification speed is 500rpm to 2000rpm and the time is 10 to 20 minutes. Using a unique cross-linking agent, the cross-linking agent is divinyl sulfone (DVS) or sodium tetraborate decahydrate, which greatly improves the existing cross-linking problem, thereby obtaining a more stable and fast cross-linking reaction and better Product performance.

Description

technical field [0001] The invention discloses a chemical preparation method, in particular to a novel preparation method of cross-linked modified starch microspheres. Background technique [0002] Starch is a natural polymer compound produced by plants through photosynthesis. It is the second largest renewable resource after cellulose and an important green chemical basic raw material. However, natural starch generally has disadvantages such as poor solubility, poor dispersibility, poor film-forming properties, easy aging and poor peptization stability, which seriously restrict its application in various industries. In order to improve the properties of natural starch and expand its application range, chemical, physical, enzymatic or compound modification treatment methods are used to introduce new functional groups on starch molecules or change the size and particle properties of starch molecules to make them more suitable for certain industries. application requirements....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/24C08L3/04C08L29/04C08L3/06C08L3/08A61L24/00A61L24/06A61L24/08
CPCA61L24/001A61L24/06A61L24/08C08J3/245A61L2400/04C08J2303/06C08J2303/04C08J2303/08C08J2429/04C08L3/04C08L3/06C08L3/08C08L29/04
Inventor 张治国索艳格黄伟孙伟庆
Owner ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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