Formula and preparation method of external preparation for allergic rhinitis

A technology for allergic rhinitis and external preparations, applied in allergic diseases, anti-inflammatory agents, pharmaceutical formulations, etc., can solve the problem of difficulty in screening out the best conditions to meet the extraction of various medicinal materials, contamination of the medium or mixture in the container, and difficulty in screening. Avoid side effects such as addiction to saliva, and achieve the effects of stable and controllable product quality, low extraction temperature, and protection of biological activity

Inactive Publication Date: 2017-09-15
郑瑞龙
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, a large number of clinical observations have shown that there are some problems in western medicine treatment: ① antihistamines can not completely relieve symptoms for some patients, especially AR patients with vasomotor rhinitis, and it is difficult to avoid side effects such as saliva; ② topical hormone- Although the curative effect is good, but - long-term use, the side effects on the body mechanism are still relatively large
For expensive traditional Chinese medicinal materials, the extraction rate is low and the cost is high by ordinary extraction technology, and the components and contents extracted by different extraction methods are not exactly the same. The combined use of extraction methods can improve the extraction rate of active components of traditional Chinese medicine, but there are few related studies
[0004] Every step of the production process of the product affects the final quality of the finished product. The research on the pre-treatment process, such as cleaning and drying, is often ignored. Only by selecting the appropriate technology can the quality of Chinese medicinal materials be guaranteed and the loss of active ingredients can be reduced. In order to simplif

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] An external preparation for allergic rhinitis is refined by using supercritical extraction technology combined with steam distillation to extract effective components of Chinese medicinal materials. The formula is processed according to the following main raw materials by weight: 10 parts of cordyceps, 10 parts of antler, 10 parts of ginseng, 25 parts of peppermint, 3 parts of menthol, 50 parts of cocklebur, and 40 parts of magnolia flower. The preparation method of described allergic rhinitis topical preparation comprises the following steps:

[0025] (1) Weigh Chinese herbal medicines such as Cordyceps antler, ginseng, peppermint, cocklebur, magnolia flower, etc. by weight, and ultrasonically clean them for 10 minutes at a power of 50W and a frequency of 40kHz, and microwave drying at a temperature of 50°C for 1h. Then pulverize through a 30-mesh sieve to obtain Chinese herbal medicine powder, which is used in steps (2) to (8) of supercritical CO 2 extraction;

[00...

Embodiment 2

[0036] An external preparation for allergic rhinitis is refined by using supercritical extraction technology combined with steam distillation to extract effective components of Chinese medicinal materials. The formula is processed according to the following main raw materials by weight: 13 parts of cordyceps, 13 parts of antler, 13 parts of ginseng, 30 parts of peppermint, 4 parts of menthol, 55 parts of cocklebur, and 45 parts of magnolia flower. The preparation method of described allergic rhinitis topical preparation comprises the following steps:

[0037] (1) Weigh Chinese herbal medicines such as Cordyceps antler, velvet antler, ginseng, peppermint, cocklebur, magnolia flower, etc. by weight, respectively, ultrasonically clean them at a power of 50W and a frequency of 40kHz for 10min, and microwave dry at a temperature of 50°C for 1h, then Crushed through a 30-mesh sieve to obtain Chinese herbal medicine powder, which is used in steps (2) to (8) of supercritical CO 2 ext...

Embodiment 3

[0048] An external preparation for allergic rhinitis is refined by using supercritical extraction technology combined with steam distillation to extract effective components of Chinese medicinal materials. The formula is processed according to the following main raw materials by weight: 15 parts of cordyceps, 15 parts of antler, 15 parts of ginseng, 35 parts of peppermint, 5 parts of menthol, 60 parts of cocklebur, and 50 parts of magnolia flower. The preparation method of described allergic rhinitis topical preparation comprises the following steps:

[0049] (1) Weigh Chinese herbal medicines such as Cordyceps antler, velvet antler, ginseng, peppermint, cocklebur, magnolia flower, etc. by weight, respectively, ultrasonically clean them at a power of 50W and a frequency of 40kHz for 10min, and microwave dry at a temperature of 50°C for 1h, then Crushed through a 30-mesh sieve to obtain Chinese herbal medicine powder, which is used in steps (2) to (8) of supercritical CO 2 ext...

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Abstract

The invention discloses a formula and a preparation method of an external preparation for allergic rhinitis, wherein the components of the external preparation mainly comprise cordyceps sinensis essential oil, cornu cervi pantotrichum essential oil, ginseng essential oil, peppermint essential oil, menthol, fructus xanthii oil, flos magnoliae liliflorae oil and menthol, and the cordyceps sinensis essential oil, the cornu cervi pantotrichum essential oil, the ginseng essential oil, the peppermint essential oil, the fructus xanthii oil and the flos magnoliae liliflorae oil are prepared from cordyceps sinensis, cornu cervi pantotrichum, ginseng, peppermint, fructus xanthii and flos magnoliae liliflorae through a supercritical CO2 extraction and steam distillation combined method. The preparation process of the preparation mainly comprises carrying out supercritical extraction on the Chinese herbs to obtain various oil-like products, extracting mixed volatile oil through a distillation method, uniformly mixing with peppermint, and sub-packaging. According to the present invention, the preparation product can effectively treat allergic rhinitis, can provide a certain treatment effect for acute and chronic rhinitis, dry rhinitis, nasal congestion, nose running, sneezing, headache, hyposmia, nasal obstruction, common cold, belly pain, diarrhea, vomiting, mosquito biting, dyspepsia, scorch by soup and fire, toothache, headache, carsickness, sea sickness and the like, and further has effects of summer-heat removing, refreshing, wind expelling, disinfection, inflammation eliminating, and the like.

Description

technical field [0001] The invention relates to a formula and a preparation method of an external preparation for allergic rhinitis, belonging to the field of traditional Chinese medicine extraction. Background technique [0002] Allergic rhinitis (AR) is an abnormal reaction in the nose caused by the body's increased sensitivity to certain allergens. The main symptoms are sudden and recurrent nasal itching, sneezing, runny nose and nasal congestion. In the past 20 years, with the improvement of industrialization level and the pollution of human environment, the patients with allergic rhinitis have increased year by year, and the incidence rate of AR in central cities of my country is 8.7%-24.1%. At present, a large number of clinical observations have shown that there are some problems in western medicine treatment: ① antihistamines can not completely relieve symptoms for some patients, especially AR patients with vasomotor rhinitis, and it is difficult to avoid side effec...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61P11/02A61P37/08A61P25/00A61P11/00A61P29/00A61P17/02A61P17/04A61P1/14A61P1/02A61P1/08A61P31/04A61K35/32A61K31/045
CPCA61K9/0043A61K31/045A61K35/32A61K36/068A61K36/258A61K36/28A61K36/534A61K36/575A61K2236/331A61K2236/37A61K2236/51A61K2300/00
Inventor 郑瑞龙
Owner 郑瑞龙
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