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Soluble micro-pin patch and preparation method thereof

A micro-needle paste and soluble technology, applied in the field of skin care products, can solve the problems of high viscosity, unfavorable preparation and molding, piercing the skin, insufficient hardness, etc., and achieve the effect of not easy to break, reduce irritation, and good mechanical strength

Active Publication Date: 2017-09-22
GUANGZHOU NEWORLD PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the existing hyaluronic acid microneedles have defects such as insufficient hardness or insufficient strength to pierce the skin, which may easily cause needle breakage, or excessive viscosity is not conducive to preparation and molding.

Method used

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  • Soluble micro-pin patch and preparation method thereof
  • Soluble micro-pin patch and preparation method thereof
  • Soluble micro-pin patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1 The dissolution rate of the base film of the microneedle patch and the test of the integrity of the peeling film

[0069] The base liquid was prepared according to the prescription in Table 1, wherein, HA-THM refers to high molecular weight sodium hyaluronate (its molecular weight is 1800k ~ 3000k Da), TL100 refers to hyaluronic acid elastomer (the super high Molecular weight polymer), PVA refers to polyvinyl alcohol. Scrape the flat base liquid with a scraper and adjust it to a corresponding thickness to obtain a base film of the desired thickness, dry it in a drying device at room temperature for 24 hours, and take it out to obtain a base film sample of the microneedle patch.

[0070] Table 1

[0071]

[0072] The complete rate of peeling off the film refers to the ratio of the weight of the most complete piece of film to the weight of all the films after peeling off the film, which is calculated according to the following formula:

[0073] FI=m1 / (m1+m2...

Embodiment 2

[0079] Example 2 The hardness and ductility of the sodium hyaluronate microneedle patch prepared with different formulation materials

[0080] Dissolve the excipient material, sodium hyaluronate (HA, molecular weight 5k-10k Da) and high-molecular-weight sodium hyaluronate (HA-THM, molecular weight 1800k-3000k Da) in 50g under stirring conditions at 30°C according to the ratio in Table 3 Water for injection, after the solution is completely dissolved, the needle tip liquid is obtained. Pour the above-mentioned needle tip liquid into a microneedle mold containing a large number of conical microholes, and recover the excess needle tip liquid after vacuuming. The diameter of the bottom edge of the conical hole is 200 μm, and the depth is 400 μm. Spread it on the needle tip liquid, and finally place the microneedle mold in a vacuum drying oven, and vacuum-dry it under heating at 30°C for 48 hours. The soluble sodium hyaluronate microneedle patch containing the active ingredients o...

Embodiment 3

[0095] Example 3 Determination of Solubility of Soluble Sodium Hyaluronate Microneedle Patch

[0096] Precisely weigh gelatin of different qualities, purified water, and sucrose according to the proportions in Table 6, place in a 50ml centrifuge tube, dissolve overnight in a 90°C water bath, centrifuge, degas, quickly transfer to a transparent petri dish, cool, and solidify into gelatin sucrose gels with different water contents.

[0097]Table 6 gelatin gel composition

[0098]

[0099] Insert the soluble microneedle patch prepared in Example 2 into the surface of the gel along the edge of the petri dish, observe from the side with an electron microscope at different time points, collect pictures, record the dissolution conditions at different time points, and observe until no obvious The microneedles were used as the end point of dissolution, and the microneedles were taken out for further observation under a microscope to confirm the dissolution time point.

[0100] The...

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Abstract

The invention relates to a soluble micro-pin patch and a preparation method thereof. The pin point of the micro-pin patch is prepared from, by weight, 7-14 parts of hyaluronic acid or salts thereof, 0.05-0.2 part of functional active ingredients, and 6-11 parts of shaped materials; the hyaluronic acid or salts thereof are mixtures of low molecular weight hyaluronic acid or salts thereof and high molecular weight hyaluronic acid or salts thereof, wherein the molecular weight of the small molecular weight hyaluronic acid or salts thereof is less than 10 kDa, the molecular weight of the high molecular weight hyaluronic acid or salts thereof is not less than 1800 kDa; the functional active ingredients are selected from oligo-peptide-1, oligopeptide-3, hydrolyzed collagen, and at least one of the hyaluronic acid or salts thereof; the shaped materials are selected from polyvinyl alcohol and derivatives thereof, polyvinyl pyrrolidone and derivatives thereof, and at least one of lactose, sorbitol, dextran, trehalose and sucrose. The soluble micro-pin patch has the properties of good rigidity and strength.

Description

technical field [0001] The invention relates to the technical field of skin care products, in particular to a soluble microneedle patch and a preparation method thereof. Background technique [0002] As a new type of transdermal drug delivery technology, microneedle has significant advantages. The traditional transdermal drug delivery is mainly subcutaneous injection. The advantage of this drug delivery method is that it breaks through the barrier of the stratum corneum and directly delivers the drug to the deep layer of the skin for accurate and effective drug delivery. The disadvantage is that it often causes pain, skin infection, and tissue damage. Injuries and other problems reduce the compliance of patients with medication; traditional transdermal drug delivery, such as drug coating, plaster patch, etc., has the advantages of convenient use, painless, and can stop the drug at any time, bypassing the first step of the liver. The disadvantage is that transdermal administ...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/65A61K8/64A61K8/81A61K8/60A61K8/34A61K8/02A61Q19/00A61Q19/08A61Q19/02A61Q17/04
CPCA61K8/0216A61K8/345A61K8/60A61K8/64A61K8/65A61K8/73A61K8/735A61K8/8176A61Q17/04A61Q19/00A61Q19/02A61Q19/08
Inventor 陈航平李革郑腾羿张敏敏
Owner GUANGZHOU NEWORLD PHARMA CO LTD
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