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A kind of radiation cross-linked hemostatic gel material and preparation method thereof

A technology of hemostatic gel and gel material, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, surgery, etc., to solve problems such as poor coagulation performance, prevent blood leakage and bacterial invasion, shorten coagulation time, The effect of rapid completion of hemostasis

Active Publication Date: 2020-05-01
HUBEI XIANGYUAN NEW MATERIAL TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the problem of poor blood coagulation performance in the prior art, and provide a hemostatic gel material with excellent radiation cross-linking blood coagulation performance and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] A method for preparing an irradiation cross-linked hemostatic gel material, comprising the following steps in sequence:

[0030] 1. Mix nano-scale chitosan, 3,6-carboxymethyl chitosan, and konjac glucomannan quaternary ammonium salt with distilled water at 40-50°C according to the required ratio to prepare a mass percentage concentration of 10%- 30% of the solution was cooled to room temperature to obtain A solution, and polyvinyl alcohol and surfactant were mixed with distilled water at a temperature greater than or equal to 90°C in the required proportion to prepare a concentration of 5% to 15% by mass. After the solution is cooled to room temperature, to obtain the B solution;

[0031] 2. First add the A solution to the B solution and mix to obtain a mixed solution, then remove the oxygen in the mixed solution and carry out irradiation crosslinking to obtain a composite hydrogel;

[0032] 3. Soak the composite hydrogel in ultrapure water to remove uncrosslinked mono...

Embodiment 1

[0045]A radiation cross-linked hemostatic gel material, the raw material composition and weight ratio of the gel material are: polyvinyl alcohol 100, nano-scale chitosan 5, 3,6-carboxymethyl chitosan 10, konjac Glucomannan quaternary ammonium salt 20, surfactant 3, wherein, the particle size of the nanoscale chitosan is 220nm; the surfactant is sodium lauryl sulfate; the 3,6-carboxymethyl Chitosan is prepared by the following method: first add 10 parts of chitosan to NaOH aqueous solution with a mass percentage concentration of 60% to prepare a solution with a mass percentage concentration of %, then stand at -20°C for 12 hours, and then add 4 parts of chloroacetic acid can be reacted at 20°C for 4.5 hours; the konjac glucomannan quaternary ammonium salt is prepared by the following method: first dissolve 20 parts of konjac glucomannan in water, and then add the mass percentage concentration Alkalinize 40% NaOH aqueous solution, then add 5 parts of 3-chloro-2-hydroxypropyltrim...

Embodiment 2

[0052] Step is with embodiment 1, and difference is:

[0053] The raw material composition and weight ratio of the gel material are: polyvinyl alcohol 100, nano-scale chitosan 25, 3,6-carboxymethyl chitosan 5, konjac glucomannan quaternary ammonium salt 4, surface active agent 2.

[0054] In order to investigate the coagulation performance and antibacterial effect of the hemostatic gel material prepared in this example, a comparison gel 2 is now prepared according to the method described in this example (the raw material composition and its weight ratio are: polyvinyl alcohol 100, nanoscale shell Polycan 25, 3,6-carboxymethyl chitosan 9, surfactant 2), and the coagulation index and antibacterial ring diameter of the gel material of this example and the comparison gel 2 were tested, and the results are shown in Table 1.

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Abstract

The invention relates to an irradiation crosslinking hemostasis gel material which comprises the following raw materials in parts by weight: 100 parts of polyvinyl alcohol, 5-25 parts of nanometer chitosan, 5-20 parts of 3,6-carboxymethyl chitosan, 4-25 parts of konjac gluconate quaternary ammonium salt and 2-10 parts of surfactant. In a preparation process, the nanometer chitosan, 3,6-carboxymethyl chitosan, konjac gluconate quaternary ammonium salt and distilled water are mixed and prepared into a solution A, the polyvinyl alcohol, the surfactant and the distilled water are mixed and prepared into a solution B, and then the solution A and the solution B are mixed and then subjected to irradiation crosslinking and lastly the non-crosslinked monomers are removed. The gel material has excellent hemostasis and antibacterial properties.

Description

technical field [0001] The invention belongs to the field of polymer material science, and in particular relates to a radiation cross-linked hemostatic gel material and a preparation method thereof. Background technique [0002] In recent years, research on hemostatic dressings at home and abroad, such as gelatin sponge, collagen dressings, chitosan / alginic acid dressings, chitosan films, chitosan non-woven fabrics, alginate fibers, etc., cut hemostatic dressings on animal skin Some hemostatic effects have been shown in the experiments. These studies are based on the good hemostasis, antibacterial, anti-inflammatory, reducing wound exudation and promoting wound tissue regeneration of this type of biomacromolecule. However, single-component biological hemostatic dressings have certain limitations, such as: easy to adhere to the wound and difficult to change the dressing, take a long time to stop bleeding, delay healing, and also have deficiencies in strength, toughness, and e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61L24/00A61L24/06A61L24/04A61L24/08
CPCA61L24/001A61L24/043A61L2400/04C08L29/04C08L5/08C08L5/00
Inventor 魏琼樊李红彭敏彭锴郭可锐易嘉琰胡志海
Owner HUBEI XIANGYUAN NEW MATERIAL TECH INC
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