Gradient elution based method for continuously separating boron-enriched isotope through ion exchange chromatography

Abstract

The invention discloses a gradient elution based method for continuously separating boron-enriched isotope through ion exchange chromatography. The method comprises the following steps: (1) feeding materials, namely, pumping a boric acid aqueous solution into a chromatographic column for ion exchange chromatography, wherein the chromatographic column is loaded on a simulated moving bed; performing material feeding adsorbing on the chromatographic column; (2) gradient eluting, namely, pumping an eluting solution into the chromatographic column, and then performing gradient eluting on the chromatographic column; and (3), collecting, namely, collecting a 10B acid solution from a lower end outlet of the chromatographic column; and evaporating and concentrating to obtain a 10B acid solid product, wherein the eluting solution for gradient eluting in step (2) is strong acid aqueous solution of which concentration continuously varies from 0 to 1 mol / L. According to the method, the strong acid aqueous solution of which the concentration continuously varies is used as the eluting solution on the simulated moving bed device, so that the enhanced separating of boron isotope is achieved; the separating capability of ion exchange chromatography is improved; the separating flow rate is increased; the separating cycle is reduced; and the abundance and the yield of the 10B acid solid product are improved.

Description

technical field [0001] The invention belongs to the field of chemical and chemical separation, and relates to an isotope separation method, in particular to a gradient elution-based method for continuously separating and enriching boron isotopes by ion exchange chromatography. Background technique [0002] Boron (B) has two stable isotopes in nature: 10 B and 11 b. in, 10 B has excellent thermal neutron absorption characteristics, high abundance 10 B, as the control material of nuclear reactor, nuclear radiation protection material, etc., is widely used in the modern nuclear energy and nuclear power industry. At the same time, it contains 10 Compound B is also used in the field of tumor treatment as a radiotherapy drug. However, in nature, 10 The B content is low, only about 19.78%. In the field of nuclear power, 10 The abundance of B is required to reach 80%-85%. In the field of cancer treatment, 10 The abundance of B is required to be 90%-95% or higher. how to se...

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Problems solved by technology

Chinese patent 200710050981.0 discloses a "process for separating boron isotopes by boron special-effect resin ion exchange chromatography", which uses chelating ion-exchange resin-boron special-effect resin as the stationary phase of ion-exchange chromatography to separate 10 B, 10 The enrichment degree of B can be increased to 91%, and the separation factor reaches 1.02, but the invention cannot realize the continuous separation of boron isotopes

[0005] Chinese patent 201010108543.7 discloses a "method for separating boron isotopes using simulated moving bed chromatography". Separation and enrichment 10 B, but the separation factor of the weakly basic anion exchange resin in this method is small, and the obtained 10 B product yield is low, it is difficult to form large-scale production

U.S. Patent No. 5,443,732 discloses a method for continuously separating boron isotopes by ion-exchange ring chromatography (Boron isotope separation using continuous ionexchange chromatography). The method uses boric acid aqueous solution as a raw material, weakly basic anion-exchange resin as an exchanger, and deionized water as Eluent, separated and enriched by circular chromatography 10 B, but this method requires the ion exchange column to have sufficient length and width, which is difficult to implement in industrial production

Chinese patent 201310531015.6 discloses a "method for separating boron isotopes using boron special effect resin as a simulated moving bed stationary phase". The method uses boron special effect resin as a stationary phase and uses a simulated moving bed device to separate boron isotopes 10 B, realized the continuous separation of boron isotopes, but this method uses hydrochloric acid solution with constant concentration as the eluent, there are still 10 Problems such as low yield of product B, small separation flow rate, long band migration distance, and long separation cycle

However, this process uses 12-22 separation columns in the analysis area of ​​the simulated moving bed as a whole for gradient elution, and cannot perform continuous and periodically repeated gradient elution on each chromatographic column in the analysis area. Separation period is still longer

[0007] Therefore, it is necessary to find a method that can continuously separate and enrich high-abundance 10 The B isotope method solves the problems of low elution flow, low abundance, low yield, and long band migration distance in the prior art. 10 The later utilization of B is very important