Spherical bioactive glass and preparation method thereof

Abstract

Provided are spherical bioactive glass and a preparation method thereof. The spherical bioactive glass is formed by performing high temperature self-combustion pretreatment and calcination on precursor gel. The precursor gel is prepared from tetraethyl orthosilicate, triethyl phosphate, calcium nitrate, magnesium nitrate, glucose, ethanol and deionized water, and the weight ratio of tetraethyl orthosilicate, triethyl phosphate, calcium nitrate, magnesium nitrate and glucose is (550-650):(200-300):(850-950):(100-200:(1000-2000); and a salpeter solution is added in the preparation process, so that the pH of the precursor gel is 2. The glucose is adopted as a template, is easy to remove under high temperature, does not remain easily, and is low in cost. The spherical bioactive glass is pretreated through a high temperature self-combustion method and is simple in process, low in energy consumption and favorable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a spherical bioactive glass and a preparation method thereof. Background technique [0002] Bioactive glass (BAG for short) is a class of biomaterials widely used in bone defects and bone repair. After implanted in the human body, it can undergo ion exchange with body fluids and form a hydroxyapatite layer of inorganic bone-like components on its surface. And the hydroxyapatite layer forms a strong chemical bond with the host bone to promote bone formation. Recent studies have also shown that in addition to bone repair, bioactive glass can also repair soft tissue and is an excellent carrier for drugs. Due to its excellent biological activity, biocompatibility and wide application prospects, the study of bioglass is of great significance. [0003] In recent years, the preparation of spherical bioactive glasses has attracted extensive attention. After the bioglass i...

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Problems solved by technology

The spherical BAG prepared by this method has a large production capacity and a perfect spherical shape, but the particle size is relatively large, and the preparation process requires a lot of special equipment, such as spray dryers, suspension combustion devices, etc., and the operation process is cumbersome and consumes a lot of energy. , the production hardware conditions are high; the organic template method mainly uses P123, F127 and other molecules as templates to form micelles in the system, induce molecular self-assembly, and finally remove them by high-temperature sintering. The particle size of the spherical glass prepared by this method can be It is as small as nanometers, and its agglomeration can be controlled by surface modification, but a large amount of templates need to be used in the preparation process of this method, and most of the templates are expensive and difficult to operate, making it difficult to achieve large-scale production; co-precipitation methods often use polyethylene glycol Alcohol, etc. as a dispersant, utilizes the affinity effect of polyethylene glycol ether bonds to make it adsorb on the surface of the precipitated particles, and wrap the precursor precipitated particles to form a steric hindrance effect, thereby inhibiting the agglomeration of the particles

This method needs to accurately grasp the amount of dispersant in the process of preparing materials. The amount of dispersant has a great influence on the spherical shape of BAG. material composition

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