Spherical bioactive glass and preparation method thereof

A bioactive glass, spherical technology, applied in glass manufacturing equipment, glass molding, manufacturing tools, etc., can solve the problems of difficult to achieve large-scale production, high requirements for production hardware conditions, expensive template agents, etc. Production, no toxic side effects, uniform size effect

Active Publication Date: 2017-11-17
HENAN UNIV OF SCI & TECH
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  • Abstract
  • Description
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Problems solved by technology

The spherical BAG prepared by this method has a large production capacity and a perfect spherical shape, but the particle size is relatively large, and the preparation process requires a lot of special equipment, such as spray dryers, suspension combustion devices, etc., and the operation process is cumbersome and consumes a lot of energy. , the production hardware conditions are high; the organic template method mainly uses P123, F127 and other molecules as templates to form micelles in the system, induce molecular self-assembly, and finally remove them by high-temperature sintering. The particle size of the spherical glass prepared by this method can be It is as small as nanometers, and its agglomeration can be controlled by surface modification, b

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  • Spherical bioactive glass and preparation method thereof
  • Spherical bioactive glass and preparation method thereof
  • Spherical bioactive glass and preparation method thereof

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[0027] Example 1

[0028] A method for preparing spherical bioactive glass. The bioactive glass is prepared by calcination of a precursor gel after high-temperature self-burning pretreatment. The precursor gel is prepared by aging the precursor sol, and the precursor sol is prepared by aging Ethyl orthosilicate, triethyl phosphate ethanol solution, calcium nitrate, magnesium nitrate, glucose deionized water solution prepared, among them, ethyl orthosilicate, triethyl phosphate, ethanol, calcium nitrate, magnesium nitrate, The ratio of glucose to deionized water is 610mg:210mg:1mL:950mg:147mg:1000mg:1mL.

[0029] The preparation method includes the following steps:

[0030] Step 1. Weigh out the ethyl orthosilicate, triethyl phosphate, calcium nitrate, magnesium nitrate, glucose, ethanol and deionized water according to the above ratio, and set aside;

[0031] Step 2: Dissolve the weighed ethyl orthosilicate and triethyl phosphate in ethanol and stir for 30 minutes to prepare solution...

Example Embodiment

[0035] Example 2

[0036] A method for preparing spherical bioactive glass. The bioactive glass is prepared by calcination of a precursor gel after high-temperature self-burning pretreatment. The precursor gel is prepared by aging the precursor sol, and the precursor sol is prepared by aging Ethyl orthosilicate, triethyl phosphate ethanol solution, calcium nitrate, magnesium nitrate, glucose deionized water solution prepared, among them, ethyl orthosilicate, triethyl phosphate, ethanol, calcium nitrate, magnesium nitrate, The ratio of glucose to deionized water is 550mg:200mg:1mL:950mg:100mg:1600mg:1mL.

[0037] The preparation method includes the following steps:

[0038] Step 1. Weigh out the ethyl orthosilicate, triethyl phosphate, calcium nitrate, magnesium nitrate, glucose, ethanol and deionized water according to the above ratio, and set aside;

[0039] Step 2: Dissolve the weighed ethyl orthosilicate and triethyl phosphate in ethanol and stir for 30 minutes to prepare solution...

Example Embodiment

[0043] Example 3

[0044] A method for preparing spherical bioactive glass. The bioactive glass is prepared from a precursor solution pretreated by high-temperature self-burning and then calcined. The precursor gel is prepared by aging the precursor sol, and the precursor sol is prepared by aging. Ethyl silicate, triethyl phosphate ethanol solution, calcium nitrate, magnesium nitrate, glucose deionized water solution prepared, among them, ethyl orthosilicate, triethyl phosphate, ethanol, calcium nitrate, magnesium nitrate, glucose The ratio of deionized water is 650mg:300mg:1mL:850mg:200mg:2000mg:1mL.

[0045] The preparation method includes the following steps:

[0046] Step 1. Weigh out the ethyl orthosilicate, triethyl phosphate, calcium nitrate, magnesium nitrate, glucose, ethanol and deionized water according to the above ratio, and set aside;

[0047] Step 2: Dissolve the weighed ethyl orthosilicate and triethyl phosphate in ethanol and stir for 30 minutes to prepare solution A...

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Abstract

Provided are spherical bioactive glass and a preparation method thereof. The spherical bioactive glass is formed by performing high temperature self-combustion pretreatment and calcination on precursor gel. The precursor gel is prepared from tetraethyl orthosilicate, triethyl phosphate, calcium nitrate, magnesium nitrate, glucose, ethanol and deionized water, and the weight ratio of tetraethyl orthosilicate, triethyl phosphate, calcium nitrate, magnesium nitrate and glucose is (550-650):(200-300):(850-950):(100-200:(1000-2000); and a salpeter solution is added in the preparation process, so that the pH of the precursor gel is 2. The glucose is adopted as a template, is easy to remove under high temperature, does not remain easily, and is low in cost. The spherical bioactive glass is pretreated through a high temperature self-combustion method and is simple in process, low in energy consumption and favorable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a spherical bioactive glass and a preparation method thereof. Background technique [0002] Bioactive glass (BAG for short) is a class of biomaterials widely used in bone defects and bone repair. After implanted in the human body, it can undergo ion exchange with body fluids and form a hydroxyapatite layer of inorganic bone-like components on its surface. And the hydroxyapatite layer forms a strong chemical bond with the host bone to promote bone formation. Recent studies have also shown that in addition to bone repair, bioactive glass can also repair soft tissue and is an excellent carrier for drugs. Due to its excellent biological activity, biocompatibility and wide application prospects, the study of bioglass is of great significance. [0003] In recent years, the preparation of spherical bioactive glasses has attracted extensive attention. After the bioglass i...

Claims

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Application Information

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IPC IPC(8): C03C12/00C03B19/10A61L27/12A61L27/10A61L27/50
CPCA61L27/10A61L27/12A61L27/50A61L2430/02A61L2430/34C03B19/1065C03C12/00
Inventor 李光大王冬梅张楠张开丽李晓玉麻开旺冯文坡谢蟪旭刘信平
Owner HENAN UNIV OF SCI & TECH
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