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Copper nanoparticle gel drug delivery system, and preparation method and application thereof

A drug-loading system, copper nanotechnology, applied in the medical field, can solve the problems of high cost, increase the economic burden of users, limit the development and application of the glue-loaded drug-loading system, etc., and achieve a low water loss rate, good swelling performance and high water retention. Effect

Active Publication Date: 2017-11-21
QUFU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, silver ions and gold ions are widely used in poly-γ-glutamic acid gel drug-loading systems, which have a high antibacterial effect, but because they are precious metals, the cost is high, which virtually increases the cost of the user. Economic burden, which limits the development and application of gel-loaded drug systems

Method used

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  • Copper nanoparticle gel drug delivery system, and preparation method and application thereof
  • Copper nanoparticle gel drug delivery system, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The preparation of a novel copper nanoparticle gel drug-carrying system, the steps are:

[0033] 1) Take each raw material according to the ratio, add nano-copper (50nm) to 30mL sterilized deionized water, sonicate for 20min, mix well, and prepare 300μg / mL copper nano solution;

[0034] 2) Take 0.7g of poly-γ-glutamic acid and add it to 5mL of sterilized deionized water, stir to dissolve to prepare a transparent solution of 0.14g / mL, and then add 5mL of the nanocopper prepared in step 1) to the transparent solution Stir the solution uniformly to obtain a nano-copper poly-γ-glutamic acid solution (the mass concentration ratio of poly-γ-glutamic acid and nano-copper is 70:0.15);

[0035] 3) Weigh 0.04g of hyaluronic acid and add it to the nano-copper poly-gamma-glutamic acid solution of step 2), stir evenly, then add 0.05g of chitosan and stir evenly to form a homogeneous solution;

[0036] 4) Heat the homogeneous solution in step 3) for 10s in microwave, and stir continuously un...

Embodiment 2

[0042] The preparation of a novel copper nanoparticle gel drug-carrying system, the steps are:

[0043] 1) Take each raw material according to the ratio, add nano copper to sterilized deionized water, sonicate for 20 minutes, mix well, and prepare 300μg / mL copper nano solution;

[0044] 2) Take 0.7g of poly-γ-glutamic acid, add it to 7.5mL of sterilized deionized water, stir to dissolve to prepare a transparent solution of 0.09g / mL, and then add the nanocopper prepared in step 1) to the transparent solution Stir the solution uniformly to obtain a nano-copper poly-γ-glutamic acid solution (the mass concentration ratio of poly-γ-glutamic acid and nano-copper is 93.3:0.1);

[0045] 3) Weigh 0.04g of hyaluronic acid and add it to the nano-copper poly-gamma-glutamic acid solution of step 2), stir evenly, then add chitosan oligosaccharides, stir evenly to form a homogeneous solution;

[0046] 4) Heat the homogeneous solution in step 3) for 15s in microwave, and continue to stir until a clea...

Embodiment 3

[0052] The preparation of a novel copper nanoparticle gel drug-carrying system, the steps are:

[0053] 1) Take each raw material according to the ratio, add nano-copper to sterilized deionized water, sonicate for 20 minutes, mix well, and prepare a 300μg / mL nano-copper solution;

[0054] 2) Take 0.7g of poly-γ-glutamic acid, add it to 2.5mL of sterilized deionized water, stir to dissolve to prepare a transparent solution of 0.28g / mL, and then add 7.5mL of the solution prepared in step 1) to the transparent solution Stir the nano-copper solution evenly to obtain a nano-copper poly-γ-glutamic acid solution (the mass concentration ratio of poly-γ-glutamic acid and nano-copper is 124.4:0.1);

[0055] 3) Weigh 0.04 g of hyaluronic acid and add it to the nano-copper poly-gamma-glutamic acid solution of step 2), stir evenly, then add chitosan oligosaccharides, stir evenly to form a homogeneous mixed solution;

[0056] 4) Heat the homogeneous solution in step 3) for 15s in microwave, and con...

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Abstract

The invention discloses a copper nanoparticle gel drug delivery system, and a preparation method and an application thereof. The raw materials of the system include copper nanoparticles, poly(gamma-glutamic acid), chitosan, hyaluronic acid, a cross-linking agent EDC / NHS and glycolipid. The nano-copper gel drug delivery system prepared in the invention can be applied to medical products, especially wound dressings. Compared with drug delivery systems in the prior art, the copper nanoparticle gel drug delivery system obtained in the invention has good biocompatibility and good antibacterial property; and the gel drug delivery system formed preferably selecting the copper nanoparticles as a drug carrier, the rhamnolipid as a drug dispersant and the hyaluronic acid as a gel stabilizer has the advantages of high water retention property, low water loss rate, higher drug entrapment rate, high drug loading capacity, high biodegradability, good swelling performance, cheap and easily available raw materials, and simple production process.

Description

Technical field [0001] The invention belongs to the field of medical technology, and relates to a copper nanoparticle gel drug-carrying system and a preparation method and application thereof. Background technique [0002] Poly-γ-glutamic acid is a kind of homopolyamino acid polymer material, which is combined in the form of amide bonds through α-NH2 and γ-COOH of glutamic acid. Therefore, there are a large number of amide bonds in the molecule and intermolecular The hydrogen bond formed has a very large molecular weight, usually around 200KD-20000KD. In nature or the human body, it can be degraded into the endogenous substance glutamic acid, which makes the molecule have good biodegradability without accumulation or toxic side effects; it contains many free carboxyl groups and is a polyanion-based biopolymer. With high water absorption and moisture retention, it is easy to combine with some drugs to form a relatively stable compound drug. It is a very ideal biodegradable medica...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K33/34A61K47/02A61K47/26A61K47/34A61K47/36A61P31/02A61K8/19A61K8/60A61K8/73A61K8/88A61Q19/00A61Q17/00A61L26/00
CPCA61K8/19A61K8/60A61K8/735A61K8/88A61K9/06A61K33/34A61K47/02A61K47/26A61K47/34A61K47/36A61K2800/95A61L26/0019A61L26/0023A61L26/008A61L2300/102A61L2300/404A61Q17/005A61Q19/00C08L5/08C08L77/04
Inventor 杨革梁鑫鑫车程川李媛刘金锋巩志金
Owner QUFU NORMAL UNIV
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