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A kind of catechol-based natural polysaccharide composite hydrogel carrier and its preparation method

A composite hydrogel and catechol-based technology, which can be used in pharmaceutical formulations, liquid delivery, medical preparations with inactive ingredients, etc., and can solve the problems of explosive release of drugs, low bioavailability, and rapid disintegration of carrier structures. , to avoid damage, enhance structural stability, and achieve the effect of good biological safety

Active Publication Date: 2020-02-07
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention aims at the disadvantages of low drug loading and difficult release control of a single polysaccharide hydrogel; and when applied in the physiological environment of the human body, there may be rapid disintegration of the carrier structure and explosive release of the drug, resulting in low bioavailability and obvious side effects, etc., and provides A preparation method of a catechol-based natural polysaccharide composite hydrogel carrier with high drug loading, controllable release rate, stable structure, and ability to withstand the electrolyte environment of the human body without disintegration

Method used

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  • A kind of catechol-based natural polysaccharide composite hydrogel carrier and its preparation method

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Experimental program
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Effect test

Embodiment 1

[0036] At room temperature (25° C.), 25 mg of dopamine (DA) was dissolved in 10 mL of deionized water, and blended with 50 μL of ammonia water (25%) under mechanical stirring to initiate polymerization. After 24h, the reaction was terminated, and the black precipitate was collected by high-speed centrifugation, washed and purified to obtain monodisperse polydopamine microspheres ( figure 1 (left)). The size, distribution and surface roughness of the microspheres are regulated by the feed ratio of DA monomer and the amount of ammonia water. The polydopamine microspheres were uniformly dispersed in sodium alginate (ALG-Na) (20mg / mL) solution (wherein the mass ratio of polydopamine microspheres to sodium alginate was 1:3), and mixed with 25mg / mL calcium chloride solution Blending to prepare polydopamine / sodium alginate composite hydrogel carrier ( figure 1 (right)).

[0037] In the drug loading and in vitro release experiments, the composite hydrogel carrier can effectively ad...

Embodiment 2

[0039] At room temperature (25° C.), 25 mg of dopamine (DA) was dissolved in 10 mL of deionized water, and blended with 50 μL of ammonia water (25%) under mechanical stirring to initiate polymerization. After 24 hours, the reaction was terminated, and the black precipitate was collected by high-speed centrifugation, washed with water, and purified to obtain monodisperse polydopamine microspheres with an average particle size greater than 150 nm. The size, distribution and surface roughness of the microspheres are regulated by the feed ratio of DA monomer and the amount of ammonia water. The polydopamine microspheres were uniformly dispersed in carboxymethyl chitosan (CMCS) (40 mg / mL) solution (wherein the mass ratio of polydopamine microspheres to carboxymethyl chitosan was 1:3), and mixed with 25 mg / mL calcium chloride solution to prepare polydopamine / carboxymethyl chitosan composite hydrogel.

[0040] In drug loading and in vitro release experiments, the composite hydrogel...

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Abstract

The invention discloses a catechol group-contained natural polysaccharide composite hydrogel carrier and a preparation method thereof, and belongs to the field of controlled / sustained-release medicine microcarriers. A catechol group-contained polymer is innovatively introduced into natural polysaccharide hydrogel, and through the adjustment of the particle size of catechol group-contained polymer microspheres, the ratio of a catechol component to anionic polysaccharide, and a crosslinking curing condition, preparation of composite hydrogel is finely controlled; by virtue of the medicine affinity of catechol groups, high-efficiency medicine load and controlled release are achieved; the process condition is simple and convenient, and the cost of raw materials is low; the prepared hydrogel carrier has broad-spectrum and high-efficiency medicine-loading capacity, the release rate can be controlled, and the bioavailability of a medicine can be significantly improved; toxic and side effects caused by sudden release and frequent medicine administration are reduced; the economic pressure of patients is reduced while the therapeutic effect is ensured. Therefore, the catechol group-contained natural polysaccharide composite hydrogel carrier and the preparation method thereof have popularization and application values.

Description

technical field [0001] The invention belongs to the field of controlled / sustained-release drug microcarriers, in particular to a composite hydrogel carrier containing catechol-based natural polysaccharides and a preparation method thereof. Background technique [0002] (1) Preparation technology of catechol-containing polymers [0003] Catechol is a kind of phenolic derivatives with adjacent hydroxyl groups, which has strong chemical activity and can adhere to the surface of most known materials. The oxidative self-polymerization of dopamine can be used to prepare catechol-containing polymers. With its good biocompatibility, biodegradability and drug loading, it is a class of pharmaceutical carrier materials with great application prospects. Illumination, nucleophile, and solvent conditions are the main factors regulating the self-polymerization of dopamine. It is a technical difficulty to optimize the purification process of the reaction product and increase the yield. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/34
CPCA61K9/0002A61K9/06A61K47/34A61K47/36
Inventor 施云峰薛巍高博闫昕
Owner JINAN UNIVERSITY
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