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An enzyme-free glucose sensor

A technology of glucose sensor and chitosan, applied in the direction of instruments, scientific instruments, material electrochemical variables, etc., can solve the problems of low sensitivity, poor sensor performance, narrow linear range, etc., to achieve strong anti-interference ability, high stability, Experimental conditions require low effects

Active Publication Date: 2019-07-30
CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, magnetic nanoparticles-based sensors usually have disadvantages of poor performance, such as low sensitivity, narrow linear range, etc.

Method used

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  • An enzyme-free glucose sensor
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  • An enzyme-free glucose sensor

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Experimental program
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Effect test

Embodiment 1

[0021] refer to Figure 1 to Figure 3 , an enzyme-free glucose sensor for the experimental determination of glucose.

[0022] Insert the present invention into 8 mL of deoxygenated 0.02 M, pH 7.4 phosphate-buffered saline (PBS) solution, and continuously inject given different concentrations of glucose to obtain corresponding current responses. Experiments show that the invented new enzyme-free glucose sensor responds quickly to changes in glucose concentration, and the reduction current can reach 95% of the steady-state current within 3 seconds. image 3 It is a linear calibration curve graph between glucose concentration and detection current, and it is a linear calibration curve graph between ampere current and glucose concentration in the range of glucose concentration 0.0075μM to 0.235mM. see image 3 Show, the linear range 7.5 μ M~4.5 mM of the present invention to the mensuration of glucose, and fitting obtains its linear equation to be I (μ A)=0.466X+0.097, linear co...

Embodiment 2

[0024] refer to Figure 1~Figure 2 , Figure 4~Figure 6 and Table 1. An enzyme-free glucose sensor for the experimental determination of hydrogen peroxide.

[0025] Insert the present invention into the PBS solution of 0.02M, pH7.4, under the applied potential of 0.1 V, continuously add hydrogen peroxide of different concentrations to obtain the i-t current response curve, see Figure 4 . Depend on Figure 4 It can be seen that: when different concentrations of hydrogen peroxide are added to the PBS solution, the enzyme-free glucose sensor of the present invention responds to the analyte immediately, with a good, stable and sharply increased current response, and the response time is about 1s. This clearly demonstrates the fast electron transfer between the inventive electrode and hydrogen peroxide. see Figure 5 , from the linear calibration curve between the concentration of hydrogen peroxide and the detection current of the present invention, it can be found that the ...

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Abstract

The invention provides a novel non-enzymatic glucose sensor which is mainly composed of an electrode modifying material and a modified electrode. The modifying material comprises a graphene iron oxide RGO-Fe2O3 nano composite material which comprises reductive graphene RGO, nano magnetic iron oxide Fe2O3 and chitosan CS, and platinum nanoparticles Pt NPs. The modified electrode is a glassy carbon electrode GCE with diameter of 3mm-6mm or a silver electrode or a gold electrode or a platinum electrode or a one-off printed graphite electrode. The novel non-enzyme glucose sensor has the beneficial effects of being wide in linear range, low in detection limit and quick in response. According to the results, the novel non-enzyme glucose sensor has good catalytic reducing ability, and an ideal choice for electrochemical hydrogen peroxide detection and glucose detection. The novel non-enzyme glucose sensor can be used for detecting glucose of the diabetic, and is wide in application prospect.

Description

technical field [0001] The invention relates to an electrochemical sensor, which is an enzyme-free glucose sensor used in the field of biomedicine. It belongs to the field of materials science and electrochemistry. Background technique [0002] Diabetes is a worldwide public health problem. Because of its unique features in the diagnosis of diabetes, the electrochemical sensor method has become a research hotspot in the detection of glucose in diabetes. According to the standard of whether the sensor needs to be added with enzyme or not, the electrochemical glucose sensor can be roughly divided into two types: glucose biosensor with enzyme and glucose sensor without enzyme. In addition to indirect measurement of hydrogen peroxide, most of the currently constructed enzyme-free glucose sensors detect the oxidation current of glucose on the electrode surface through direct measurement. Therefore, the electrocatalytic activity of the biosensitive material on the electrode surf...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/327
CPCG01N27/30G01N27/3278
Inventor 徐文峰张园园廖晓玲陈沉
Owner CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
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