Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel non-enzymatic glucose sensor

A glucose sensor, a new type of technology, applied in the fields of materials science and electrochemistry, can solve the problems of poor sensor performance, narrow linear range, and low sensitivity, and achieve high stability, low experimental condition requirements, and strong anti-interference ability

Active Publication Date: 2017-12-01
CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
View PDF5 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, magnetic nanoparticles-based sensors usually have disadvantages of poor performance, such as low sensitivity, narrow linear range, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel non-enzymatic glucose sensor
  • Novel non-enzymatic glucose sensor
  • Novel non-enzymatic glucose sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] refer to Figure 1 to Figure 3 , a novel enzyme-free glucose sensor for the experimental determination of glucose.

[0022] Insert the present invention into 8 mL of deoxygenated 0.02 M, pH 7.4 phosphate-buffered saline (PBS) solution, and continuously inject given different concentrations of glucose to obtain corresponding current responses. Experiments show that the invented new enzyme-free glucose sensor responds quickly to changes in glucose concentration, and the reduction current can reach 95% of the steady-state current within 3 seconds. image 3 It is a linear calibration curve graph between glucose concentration and detection current, and it is a linear calibration curve graph between ampere current and glucose concentration in the range of glucose concentration 0.0075μM to 0.235mM. see image 3 Show, the linear range 7.5 μ M~4.5 mM of the present invention to the mensuration of glucose, and fitting obtains its linear equation to be I (μ A)=0.466X+0.097, line...

Embodiment 2

[0024] refer to Figure 1~Figure 2 , Figure 4~Figure 6 and Table 1. A Novel Enzyme-Free Glucose Sensor for the Experimental Determination of Hydrogen Peroxide.

[0025] Insert the present invention into 0.02M, pH7.4 PBS solution, under the applied potential of 0.1 V, continuously add hydrogen peroxide of different concentrations to obtain the i-t current response curve, see Figure 4 . Depend on Figure 4 It can be seen that: when different concentrations of hydrogen peroxide are added to the PBS solution, the enzyme-free glucose sensor of the present invention responds to the analyte immediately, with a good, stable and sharply increased current response, and the response time is about 1s. This clearly demonstrates the fast electron transfer between the inventive electrode and hydrogen peroxide. see Figure 5 , from the linear calibration curve between the concentration of hydrogen peroxide and the detection current of the present invention, it can be found that the -...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Sensitivityaaaaaaaaaa
Login to View More

Abstract

The invention provides a novel non-enzymatic glucose sensor which is mainly composed of an electrode modifying material and a modified electrode. The modifying material comprises a graphene iron oxide RGO-Fe2O3 nano composite material which comprises reductive graphene RGO, nano magnetic iron oxide Fe2O3 and chitosan CS, and platinum nanoparticles Pt NPs. The modified electrode is a glassy carbon electrode GCE with diameter of 3mm-6mm or a silver electrode or a gold electrode or a platinum electrode or a one-off printed graphite electrode. The novel non-enzyme glucose sensor has the beneficial effects of being wide in linear range, low in detection limit and quick in response. According to the results, the novel non-enzyme glucose sensor has good catalytic reducing ability, and an ideal choice for electrochemical hydrogen peroxide detection and glucose detection. The novel non-enzyme glucose sensor can be used for detecting glucose of the diabetic, and is wide in application prospect.

Description

technical field [0001] The invention relates to an electrochemical sensor, which is a novel enzyme-free glucose sensor used in the field of biomedicine in terms of use. It belongs to the field of materials science and electrochemistry. Background technique [0002] Diabetes is a worldwide public health problem. Because of its unique features in the diagnosis of diabetes, the electrochemical sensor method has become a research hotspot in the detection of glucose in diabetes. According to the standard of whether the sensor needs to be added with enzyme or not, the electrochemical glucose sensor can be roughly divided into two types: glucose biosensor with enzyme and glucose sensor without enzyme. In addition to indirect measurement of hydrogen peroxide, most of the currently constructed enzyme-free glucose sensors detect the oxidation current of glucose on the electrode surface through direct measurement. Therefore, the electrocatalytic activity of the biosensitive material ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/327
CPCG01N27/30G01N27/3278
Inventor 徐文峰张园园廖晓玲陈沉
Owner CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com