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Polyphenol-based coordination polymer nano-particle and preparation method thereof

A technology of coordination polymers and nanoparticles, applied in the field of biomedical new materials, can solve the problems of toxicity restricting clinical application, etc., and achieve the effect of low price, mild conditions and simple preparation

Inactive Publication Date: 2017-12-08
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These nanoparticles have a good EPR effect and can accumulate in tumors. Although they have good cancer therapeutic effects, their long-term toxicity restricts their clinical application.

Method used

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  • Polyphenol-based coordination polymer nano-particle and preparation method thereof
  • Polyphenol-based coordination polymer nano-particle and preparation method thereof
  • Polyphenol-based coordination polymer nano-particle and preparation method thereof

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preparation example Construction

[0029] The invention provides a preparation method of polyphenol-based coordination polymer nanoparticles, comprising:

[0030] The coordination polymer nanoparticles are obtained by reacting and coordinating polyethylene glycol-modified polyglutamic acid, ferric salt and polyphenol.

[0031] The preparation method of the polyphenol-based coordination polymer nanoparticles of the present invention is to coordinate the polyglutamic acid modified by polyethylene glycol, ferric salt and polyphenol reaction to obtain the coordination polymer nanoparticles; preferably specifically :

[0032] The polyethylene glycol-modified polyglutamic acid and ferric salt are mixed and stirred, then polyphenol is added, stirred, centrifuged and ultrasonically dispersed to obtain polymer nanoparticles.

[0033] Firstly, polyethylene glycol-modified polyglutamic acid is provided or prepared, which has been clearly described above and will not be repeated here.

[0034] In the present invention, t...

Embodiment 1～16

[0060] The molecular weights of polyethylene glycol and polyglutamic acid were respectively selected to be 5000Da and 21600Da, and the molar ratio was 5:1. Dissolve polyethylene glycol-modified polyglutamic acid in water, add ferric chloride solution, mix and stir for 4 hours, and slowly add polyphenol dropwise under rapid stirring at a rate of 0.5mL / min, and add polyphenol The final mixing and stirring time is 12h. Centrifuge after the mixing and stirring, the centrifugal speed is selected as 8000rpm, and the centrifugal time is selected as 10min. After ultrasonic dispersion, coordination polymer nanoparticles were prepared. The types and amounts of polyethylene glycol, polyglutamic acid, ferric chloride, and polyphenols are shown in Table 1.

[0061] The consumption of table 1 embodiment 1~16 different raw materials

[0062]

[0063] Utilize the transmission electron microscope to analyze the coordination polymer nanoparticles prepared in embodiment 6 respectively, and...

Embodiment 17

[0065]The coordination polymer nanoparticles obtained in Example 6 were injected into the mice through the tail vein, and the blood was collected from the eyeballs at 1h, 2h, 3h, 6h, 12h, 24h, and 48h respectively. Blood was used as blank control. After the experiment, the iron content in the blood was measured by ICP-MS, and the metabolism was calculated.

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Abstract

The invention provides a polyphenol-based coordination polymer nano-particle which is prepared from polyphenol, ferric iron salt and polyethylene glycol-modified polyglutamic acid. The polyphenol, the ferric iron salt and the polyethylene glycol-modified polyglutamic acid are adopted and coordinated to prepare the polymer nano-particle; the polymer nano-particle has the advantages that the preparation is simple, the condition is mild, the operation is easy, the sources of raw materials are low-toxic or non-toxic, and the price is low. The prepared coordination polymer nano-particle has a long circulatory function; the particle size ranges from 80nm to 110nm, the polymer nano-particle has an appropriate nano size, an EPR (electron paramagnetic resonance) effect can be realized, and accumulation can be realized in a tumor area. The polymer nano-particle has a dual mode imaging function, i.e., photoacoustic imaging and magnetic resonance imaging; the polymer nano-particle can be used for performing accurate photothermal therapy under the guidance of imaging.

Description

technical field [0001] The invention relates to the technical field of biomedical new materials, in particular to a polyphenol-based coordination polymer nanoparticle and a preparation method thereof. Background technique [0002] The principle of photothermal therapy is to use the heat generated by a photothermal conversion agent with near-infrared light absorption properties to kill cancer cells. Since near-infrared light is rarely absorbed by biological tissues, it has good tissue penetration and high specificity , almost does not cause harm and side effects to normal tissue cells, and has obvious advantages compared with traditional treatment methods (see YangK, Zhang S, Zhang G, Sun X, Lee ST, Liu Z.Graphene in mice: ultrahigh in vivo tumoruptake and efficient photothermal therapy. Nano Lett. 2010; 10(9):3318-23.). However, an important prerequisite for photothermal therapy is to accurately diagnose tumor tissue and obtain relevant information such as tumor size and lo...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K49/18A61K49/14A61K41/00A61P35/00
CPCA61K41/0052A61K49/0002A61K49/146A61K49/1872A61K49/225
Inventor 田华雨徐彩娜王艳兵陈杰林琳郭兆培陈学思
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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